Bone and Connective Tissue
Diseases of bone (such as osteoporosis) and connective tissue (rheumatoid arthritis, lupus) can be studied in cell and animal models with small molecules that regulate immunity, inflammation, protein folding, and certain key kinases like JAK.
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Pazopanib | Multi-receptor tyrosine kinase inhibitor
CAS:444731-52-6Catalog Number:10-2158 -
Salubrinal | eIF2α Phosphatase inhibitor
From $55.00CAS:405060-95-9Catalog Number:10-4517Activity:eIF2α Phosphatase inhibitorChemical Name:3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamideMolecular Weight:479.81Molecular Formula:C21H17Cl3N4OSSolubility:Soluble in DMSO (up to 25 mg/ml),Physical Properties:Beige solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.Shipping Code:RT -
SB 203580 | p38 MAP kinase inhibitor
From $60.00CAS:152121-47-6Catalog Number:10-2173Activity:p38 MAP kinase inhibitorChemical Name:4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)imidazoleMolecular Weight:377.44Molecular Formula:C21H16N3OSFSolubility:Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 10 mg/ml with warming).Physical Properties:Off-white solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
Z-Phe-Tyr-CHO | Cathepsin L inhibitor
From $30.00CAS:167498-29-5Catalog Number:10-3079Activity:Cathepsin L inhibitorAlternate Names:Z-FY-CHO; Z-Phe-Tyr-Aldehyde; SB-412515Molecular Weight:446.50Molecular Formula:C26H26N2O5Solubility:Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 50 mg/ml)Physical Properties:Off-white to pale yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.Shipping Code:RT -
Zoledronic acid | Inhibitor of bone resorption
From $45.00CAS:118072-93-8Catalog Number:10-4512Activity:Antiproliferative and apopototic effectsAlternate Names:CGP 42446Chemical Name:[1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid)Molecular Weight:272.09Molecular Formula:C5H10N2O7P2Solubility:Soluble in Water (up to 2 mg/ml).Physical Properties:White or off-white solidPurity:98% by HPLCStorage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 2 months.Shipping Code:RT
