Cytokine modulators
Cytokines are a diverse group of small proteins comprising interleukins, interferons, chemokines, lymphokines, and tumor necrosis factors (TNF). Not only are they key players in inflammation and immune response, but they also have roles in wound healing, cell cycling and death, and cancer progression. Their receptors are just as diverse, being immunoglobulins and transmembrane proteins that transmit signals via kinases and GPCRs.
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PF-4136309 | CCR2 antagonist
From $75.00CAS:1341224-83-6Catalog Number:10-4261Activity:CCR2 antagonistChemical Name:N-[2-[(3S)-3-[[4-Hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-2-oxoethyl]-3-(trifluoromethyl)benzamideAlternate Name:INCB8761Molecular Weight:568.60Molecular Formula:C29H31F3N6O3Solubility:Soluble in DMSO (up to at least 25 mg/ml)Physical Properties:Off-white solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Plerixafor | CXCR4 antagonist
From $65.00CAS:155148-31-5Catalog Number:10-2864Activity:CXCR4 antagonistMolecular Weight:794.48Molecular Formula:C28H54N8 • 8HClSolubility:Soluble in Water (up to at least 55 mg/ml)Physical Properties:White solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.Shipping Code:RT -
Pomalidomide | Cereblon ubiquitination inhibitor
From $50.00CAS:19171-19-8Catalog Number:10-2768Activity:Cereblon ubiquination inhibitorChemical Name:1,3-Dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline; 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamideMolecular Weight:273.24Molecular Formula:C13H11N3O4Solubility:Soluble in DMSO (up to 50 mg/ml).Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT -
Ponatinib | Bcr-Abl and multikinase inhibitor
From $50.00CAS:943319-70-8Catalog Number:10-5064Activity:Bcr-Abl and multikinase inhibitorChemical Name:3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamideAlternate Name:AP-24534Molecular Weight:532.56Molecular Formula:C29H27F32N6OSolubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml with warming).Physical Properties:Yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
Reparixin | CXCR 1/2 allosteric antagonist
From $52.00CAS:266359-83-5Catalog Number:10-2527Activity:CXCR 1/2 allosteric antagonistChemical Name:αR-Methyl-4-(2-methylpropyl)-N-(methylsulfonyl)-benzeneacetamideAlternate Names:DF 1681Y; RepertaxinMolecular Weight:283.39Molecular Formula:C14H21NO3SSolubility:Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 25 mg/ml)Physical Properties:White solidPurity:99% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Rocaglamide | TNFalpha inhibitor
From $60.00CAS:84573-16-0Catalog Number:10-2484Activity:TNFalpha inhibitorMolecular Weight:505.57Molecular Formula:C29H31NO7Solubility:Soluble in DMSO or EthanolPhysical Properties:White solid supplied as a thin film on vial.Purity:97% by HPLCStorage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. Protect from exposure to light and moisture.Shipping Code:RT
