Cytokine modulators

Cytokines are a diverse group of small proteins comprising interleukins, interferons, chemokines, lymphokines, and tumor necrosis factors (TNF). Not only are they key players in inflammation and immune response, but they also have roles in wound healing, cell cycling and death, and cancer progression. Their receptors are just as diverse, being immunoglobulins and transmembrane proteins that transmit signals via kinases and GPCRs.

  • MCC950 | NLRP3 inflammasome inhibitor

    CAS:
    210826-40-7
    Catalog Number:
    10-2990
    Activity:
    NLRP3 inflammasome inhibitor
    Chemical Name:
    N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt
    Alternate Names:
    CRID3; CP-456773 sodium salt
    Molecular Weight:
    426.46
    Molecular Formula:
    C20H23N2O5S
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Water (up to 30 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
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  • MIF20 chemical structure

    MIF20 | MIF agonist

    CAS:
    1191288-81-9
    Catalog Number:
    10-4393
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  • PF-4136309 | CCR2 antagonist

    CAS:
    1341224-83-6
    Catalog Number:
    10-4261
    Activity:
    CCR2 antagonist
    Chemical Name:
    N-[2-[(3S)-3-[[4-Hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-2-oxoethyl]-3-(trifluoromethyl)benzamide
    Alternate Name:
    INCB8761
    Molecular Weight:
    568.60
    Molecular Formula:
    C29H31F3N6O3
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
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  • plerixafor chemical structure

    Plerixafor | CXCR4 antagonist

    CAS:
    155148-31-5
    Catalog Number:
    10-2864
    Activity:
    CXCR4 antagonist
    Molecular Weight:
    794.48
    Molecular Formula:
    C28H54N8 • 8HCl
    Solubility:
    Soluble in Water (up to at least 55 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
    From $55.00
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  • Pomalidomide | Cereblon ubiquitination inhibitor

    CAS:
    19171-19-8
    Catalog Number:
    10-2768
    Activity:
    Cereblon ubiquination inhibitor
    Chemical Name:
    1,3-Dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline; 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide
    Molecular Weight:
    273.24
    Molecular Formula:
    C13H11N3O4
    Solubility:
    Soluble in DMSO (up to 50 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
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  • Ponatinib | Bcr-Abl and multikinase inhibitor

    CAS:
    943319-70-8
    Catalog Number:
    10-5064
    Activity:
    Bcr-Abl and multikinase inhibitor
    Chemical Name:
    3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide
    Alternate Name:
    AP-24534
    Molecular Weight:
    532.56
    Molecular Formula:
    C29H27F32N6O
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml with warming).
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date  of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
    From $50.00
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