Cytokine modulators

Cytokines are a diverse group of small proteins comprising interleukins, interferons, chemokines, lymphokines, and tumor necrosis factors (TNF). Not only are they key players in inflammation and immune response, but they also have roles in wound healing, cell cycling and death, and cancer progression. Their receptors are just as diverse, being immunoglobulins and transmembrane proteins that transmit signals via kinases and GPCRs.

  • Reparixin | CXCR 1/2 allosteric antagonist

    CAS:
    266359-83-5
    Catalog Number:
    10-2527
    Activity:
    CXCR 1/2 allosteric antagonist
    Chemical Name:
    αR-Methyl-4-(2-methylpropyl)-N-(methylsulfonyl)-benzeneacetamide
    Alternate Names:
    DF 1681Y; Repertaxin
    Molecular Weight:
    283.39
    Molecular Formula:
    C14H21NO3S
    Solubility:
    Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $52.00
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  • Ritlecitinib chemical structure

    Ritlecitinib | JAK3 inhibitor

    CAS:
    1792180-81-4
    Catalog Number:
    10-4377
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  • Rocaglamide

    Rocaglamide | TNFalpha inhibitor

    CAS:
    84573-16-0
    Catalog Number:
    10-2484
    Activity:
    TNFalpha inhibitor
    Molecular Weight:
    505.57
    Molecular Formula:
    C29H31NO7
    Solubility:
    Soluble in DMSO or Ethanol
    Physical Properties:
    White solid supplied as a thin film on vial.
    Purity:
    97% by HPLC
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. Protect from exposure to light and moisture.
    Shipping Code:
    RT
    From $100.00
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  • Ruxolitinib chemical structure

    Ruxolitinib | JAK inhibitor

    CAS:
    941678-49-5
    Catalog Number:
    10-4511
    Activity:
    JAK inhibitor
    Alternate Names:
    INCB 018424
    Chemical Name:
    βR-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile
    Molecular Weight:
    306.37
    Molecular Formula:
    C17H18N6
    Solubility:
    Soluble in DMSO (up to 28 mg/ml) or in Ethanol (up to 15 mg/ml with warming).
    Physical Properties:
    White solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
    From $65.00
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  • SB-225002 | CXCR2 antagonist

    CAS:
    182498-32-4
    Catalog Number:
    10-2850
    Activity:
    CXCR2 antagonist
    Chemical Name:
    N-(2-Bromophenyl)-N’-(2-hydroxy-4-nitrophenyl)urea
    Molecular Weight:
    352.14
    Molecular Formula:
    C13H10BrN3O4
    Solubility:
    Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $60.00
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  • Sivelestat sodium | Leukocyte elastase inhibitor

    CAS:
    201677-61-4
    Catalog Number:
    10-1102
    Activity:
    Leukocyte elastase inhibitor
    Alternate Names:
    ONO-5046
    Chemical Name:
    N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine sodium hydrate
    Molecular Weight:
    528.51
    Molecular Formula:
    C20H21N2O7S·Na·4H2O
    Solubility:
    Soluble in DMSO (up to 20 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
    Shipping Code:
    RT
    From $54.00
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