Cytokine modulators
Cytokines are a diverse group of small proteins comprising interleukins, interferons, chemokines, lymphokines, and tumor necrosis factors (TNF). Not only are they key players in inflammation and immune response, but they also have roles in wound healing, cell cycling and death, and cancer progression. Their receptors are just as diverse, being immunoglobulins and transmembrane proteins that transmit signals via kinases and GPCRs.
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Rocaglamide | TNFalpha inhibitor
From $100.00CAS:84573-16-0Catalog Number:10-2484Activity:TNFalpha inhibitorMolecular Weight:505.57Molecular Formula:C29H31NO7Solubility:Soluble in DMSO or EthanolPhysical Properties:White solid supplied as a thin film on vial.Purity:97% by HPLCStorage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. Protect from exposure to light and moisture.Shipping Code:RT -
Ruxolitinib | JAK inhibitor
From $65.00CAS:941678-49-5Catalog Number:10-4511Activity:JAK inhibitorAlternate Names:INCB 018424Chemical Name:βR-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrileMolecular Weight:306.37Molecular Formula:C17H18N6Solubility:Soluble in DMSO (up to 28 mg/ml) or in Ethanol (up to 15 mg/ml with warming).Physical Properties:White solidPurity:99% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
SB-225002 | CXCR2 antagonist
From $60.00CAS:182498-32-4Catalog Number:10-2850Activity:CXCR2 antagonistChemical Name:N-(2-Bromophenyl)-N’-(2-hydroxy-4-nitrophenyl)ureaMolecular Weight:352.14Molecular Formula:C13H10BrN3O4Solubility:Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml)Physical Properties:Yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Sivelestat sodium | Leukocyte elastase inhibitor
From $54.00CAS:201677-61-4Catalog Number:10-1102Activity:Leukocyte elastase inhibitorAlternate Names:ONO-5046Chemical Name:N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine sodium hydrateMolecular Weight:528.51Molecular Formula:C20H21N2O7S·Na·4H2OSolubility:Soluble in DMSO (up to 20 mg/ml).Physical Properties:White solidPurity:98% by HPLCStorage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 monthsShipping Code:RT -
SX-682 | CXCR1/2 inhibitor
From $90.00CAS:1648843-04-2Catalog Number:10-4925Activity:CXCR1/2 inhibitorChemical Names:[2-[[5-[(4-Fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acidMolecular Weight:467.20Molecular Formula:C19H14BF4N3O4SSolubility:Soluble in DMSO (>25 mg/ml)Physical Properties:Off-white solidPurity:>98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT
