Cytokine modulators
Cytokines are a diverse group of small proteins comprising interleukins, interferons, chemokines, lymphokines, and tumor necrosis factors (TNF). Not only are they key players in inflammation and immune response, but they also have roles in wound healing, cell cycling and death, and cancer progression. Their receptors are just as diverse, being immunoglobulins and transmembrane proteins that transmit signals via kinases and GPCRs.
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JTE-607 | mRNA processing inhibitor
From $60.00CAS:188791-09-5Catalog Number:10-4842Activity:mRNA processing inhibitorChemical Name:Ethyl (2S)-2-[[3,5-Dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]amino]-3-phenylpropanoate dihydrochlorideMolecular Weight:597.36Molecular Formula:C25H31Cl2N3O5 • 2HClSolubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:Off-white to pale yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20° (des.)Stability:Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT -
L524-0366 | Fn14 antagonist
From $65.00CAS:951612-19-4Catalog Number:10-1536Activity:Fn14 antagonistChemical Name:(1-(3-Chlorophenyl)-1H-1,2,3-triazol-4-yl)(thiomorpholino)methanoneMolecular Weight:308.79Molecular Formula:C13H13ClN4OSSolubility:Soluble in DMSO (up to 14 mg/ml with warming) or in Ethanol (up to 2 mg/ml with warming).Physical Properties:Beige solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchsae as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
Lisofylline (racemic) | Anti-diabetic and Antiinflammatory agent
From $50.00CAS:6493-06-7Catalog Number:10-2781Activity:Anti-diabetic and Antiinflammatory agentAlternate Names:LSF; BL-194Chemical Name:1-(5-Hydroxyhexyl)-3,7-dimethylpurine-2,6-dione (racemic)Molecular Weight:280.33Molecular Formula:C13H20N4O3Solubility:Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 20 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.Shipping Code:RT -
Locostatin | RKIP/Raf-1 kinase disruptor
From $48.00CAS:133812-16-5Catalog Number:10-5381Activity:RKIP/Raf-1 kinase disruptorChemical Names:(4S)-3-[(E)-But-2-enoyl]-4-benzyl-2-oxazolidinone; UIC-1005Molecular Weight:245.28Molecular Formula:C14H15O3Solubility:Soluble in DMSO (60 mg/ml)Physical Properties:Off-white solidPurity:>98% TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Maraviroc | CCR5 Antagonist
From $50.00CAS:376348-65-1Catalog Number:10-4260Activity:CCR5 AntagonistChemical Name:4,4-Difluoro-N-[(1S)-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamideAlternate Name:UK-427,857Molecular Weight:513.68Molecular Formula:C29H41F2N5OSolubility:Soluble in DMSO (>25 mg/ml)Physical Properties:White solidPurity:>98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
MCC-950 | NLRP3 inflammasome inhibitor
From $56.00CAS:210826-40-7Catalog Number:10-2990Activity:NLRP3 inflammasome inhibitorChemical Name:N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium saltAlternate Names:CRID3; CP-456773 sodium saltMolecular Weight:426.46Molecular Formula:C20H23N2O5SSolubility:Soluble in DMSO (up to 40 mg/ml) or in Water (up to 30 mg/ml)Physical Properties:White solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.Shipping Code:RT
