WNT/ß-CATENIN

Activators

  • SKL2001 | Wnt/ß-Catenin pathway activator
    CAS:
    909089-13-0
    Catalog Number:
    10-4379
  • LY2090314 | Wnt/ß-Catenin pathway activator/GSK-3 inhibitor
    CAS:
    603288-22-8
    Catalog Number:
    10-4854
  • IM-12 | GSK-3ß inhibitor
    CAS:
    1129669-05-1
    Catalog Number:
    10-5125
    Activity:
    GSK-3ß inhibitor
    Chemical Names:
    3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
    Molecular Weight:
    377.41
    Molecular Formula:
    C22H20FN3O2
    Solubility:
    Soluble in DMSO (50 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • NOTUMib-1 | NOTUM inhibitor, restores Wnt signaling
    Catalog Number:
    10-3756
    Activity:
    NOTUM inhibitor, restores Wnt signaling
    Chemical Name:
    N-(Isoquinolin-6-yl)-2-(o-tolyloxy)acetamide
    Molecular Weight:
    292.33
    Molecular Formula:
    C18H16N2O2
    Solubility:
    Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
    Physical Properties:
    Beige solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20° (des.)
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • CHIR-99021 | GSK3ß inhibitor
    CAS:
    252917-06-9
    Catalog Number:
    10-1279
    Activity:
    GSK3β inhibitor
    Chemical Name:
    6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
    Molecular Weight:
    465.35
    Molecular Formula:
    C22H18Cl2N8
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    Tan solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Activators Products

Inhibitors

  • IWP-4 | Wnt/Porcn inhibitor
    CAS:
    686772-17-8
    Catalog Number:
    10-3370
  • Intelliscreen™ Wnt/β-catenin (canonical) Mini-Library
    Catalog Number:
    10-7305
    Description:
    12 inhibitors of the various components of this pathway.
    Solubility:
    DMSO
    Supplied As:
    DMSO solution @ 10mM
    Storage Temperature:
    -80°C
    Stability:
    Stable for up to 1 year when stored as supplied @ -80°C
    Price:
    $475.00
  • Nitazoxanide | Wnt signaling inhibitor
    CAS:
    55981-09-4
    Catalog Number:
    10-4633
    Activity:
    Wnt signaling inhibitor
    Chemical Names:
    O-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenyl acetate; NTZ
    Molecular Weight:
    307.28
    Molecular Formula:
    C12H9N3O5S
    Solubility:
    Soluble in DMSO (>50 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • IWR-1 endo | Wnt signaling inhibitor
    CAS:
    1127442-82-3
    Catalog Number:
    10-5081
    Activity:
    Wnt signaling inhibitor
    Molecular Weight:
    409.44
    Molecular Formula:
    C25H19N3O2
    Solubility:
    Soluble in DMSO (up to 10 mg/ml)
    Physical Properties:
    Off-white or yellow solid
    Purity:
    98% by TLC/HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Emetine hydrochloride | Protein synthesis inhibitor
    CAS:
    316-42-7
    Catalog Number:
    10-3001
    Activity:
    Protein synthesis inhibitor
    Chemical Names:
    (2S,3R,11bS)-3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-2H-benzo[a]quinolizine dihydrochloride hydrate
    Molecular Weight:
    553.56
    Molecular Formula:
    C29H40N2O4·2HCl·XH2O
    Solubility:
    Soluble in Water (100 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Inhibitors Products

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