July 9, 2024
Focus on Natural Products: Microcystin LR, a cyanobacterial toxin that inhibits protein phosphatase 2A, was recently shown to stimulate tumor-associated macrophages to adopt an anti-tumor M1 […]
June 27, 2024
On World Microbiome Day (June 27, 2024) we focus on gut microbial metabolites. Phenylacetyl-L-glutamine (PAGln) was shown to be a cardiovascular disease-linked gut microbial metabolite acting […]
June 27, 2024
Focus on Bioactive Natural Products: Verrucarin A, a structurally intriguing natural product produced by soil microbe Myrothecium spp. was shown by Kondo et al. to attenuate […]
June 27, 2024
Focus on Bioactive Natural Products: Just out in ACS Chemical Biology, FA Gowans and coworkers at Berkeley reported that ophiobolin A (OPA) covalently targets mitochondrial complex […]
June 14, 2024
Beauvericin, a mycotoxin produced by various Fusarium spp, is an important food and animal feed contaminant. Its diverse toxic activities coupled with its ability to cross […]
June 12, 2024
An interesting review has just been published in the May 23 issue of Cell by A Suomalainen and J Nunnari entitled “Mitochondria at the Crossroads of […]
June 12, 2024
In a paper just out in Nature Aging, Goro Katsuumi and coworkers in Tokyo demonstrated that inhibition of sodium-glucose co-transporter 2 (SGLT2) with canagliflozin enhanced clearance […]
March 29, 2024
Last week the FDA approved Italfarmaco’s givinostat (ITF2357) for Duchenne muscular dystrophy. Givinostat is a novel histone deacetylase (HDAC) inhibitor and was approved for DMD patients […]
March 26, 2024
Focus Biomolecules will be exhibiting at the annual meeting of American Association for Cancer Research (AACR) in San Diego, April 7 – 10. Stop by our […]
