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September 20, 2022

BAM15 attenuates sepsis hyperinflammation

P. Hiengrach and coworkers recently showed that BAM15, a mitochondrial uncoupling agent, attenuated sepsis in a mouse cecal ligation and puncture model. BAM15 attenuated sepsis as […]
September 15, 2022

Inducing Autophagy Against Mycobacterial Infection

Activation of autophagy is a novel mode of therapeutic intervention and offers the possibility of developing new “host-directed” therapeutics against mycobacterial infection. For example, Kim et […]
September 12, 2022

Lifespan Extension by Rapamycin

Paula Juricic and coworkers at the Max Planck Institute for Biology of Ageing report in a recent issue of Nature Aging that a brief early treatment […]
September 8, 2022

HDAC3 Inhibition Stimulates Myelination

Robert Prior and coworkers report in a recent issue of Molecular Neurobiology that inhibition of HDAC3 with RGFP966, a highly selective HDAC3 inhibitor, stimulates myelination in […]
September 6, 2022

Canagliflozin Effects on Murine Lifespan

JM Snyder and coworkers report in the August issue of Geroscience that canagliflozin, a clinically important anti-diabetic agent, results in a 14% increase in median lifespan […]
September 1, 2022

Stem Cell Viability

Chroman 1 is an important new small molecule tool for the generation and maintenance of stem cells. An extremely potent (1 pM) inhibitor of Rho kinase […]
August 25, 2022

Epigenetics and Inflammation

In a recent paper in Cell Research, Li and coworkers explored the nuclear function of RIPK1 and demonstrated that RIPK1 phosphorylates a key component of the […]
August 12, 2022

Synthesis and Characterization of Destruxins

In the August issue of J. Antibiotics (Tokyo) Yoshida and coworkers at the University of Tsukuba reviewed their excellent work on synthesis, SAR, biology and chemical […]
August 1, 2022

Tumor immune surveillance news

Yan and coworkers have demonstrated a potential way to boost innate immune attack on solid tumors. They found that Rocaglamide, a structurally novel natural product, promoted […]