Synthesis and Characterization of Destruxins
In the August issue of J. Antibiotics (Tokyo) Yoshida and coworkers at the University of Tsukuba reviewed their excellent work on synthesis, SAR, biology and chemical biology of the Destruxins, fungal cyclodepsipeptides from Metarhizium sp. They developed a practical synthesis using a macrolactonization strategy allowing gram scale production; synthesized 64 analogs; carried out SAR studies; …