January 13, 2023
Resorcylic acid lactones are a diverse family of fungal natural products which possess a variety of useful pharmacological activities. For example: Radicicol Hypothemycin and others are […]
January 9, 2023
Apoptolidin is a novel microbial natural product isolated from Nocardiopsis sp. It was shown to be a powerful inducer of apoptosis in a variety of cancer […]
December 22, 2022
In a recent paper in Nature, Bryan Roth et al. revealed detailed features in the recognition of DREADD actuators by designer receptors. Muscarinic DREADDs or designer […]
December 15, 2022
Urolithin A is a microbial metabolite of dietary ellagitannins produced in the gut. It has been shown to induce mitophagy and prolong lifespan in C. elegans […]
November 28, 2022
Focus will be exhibiting at ASCB Cell Biology, Dec 3-7 in Washington DC. Stop by our booth #2205 and chat with our scientists! Learn about our […]
November 28, 2022
Filipin III is a microbial natural product isolated from Streptomyces filipinensis. It is an important fluorescent probe for cellular cholesterol detection. In addition, because it binds […]
November 22, 2022
Two recent papers employed Sinefungin in determination of the structure of two different viral methyltransferases. Sinefungin is a Streptomyces natural product analog of S-adenosylmethionine acting as […]
October 14, 2022
In a molecular docking analysis, Tronco Pauletto et al. found that antidepressants such as fluoxetine, citalopram, and norfluoxetine likely interact with and disrupt SARS-CoV-2 main protease […]
October 14, 2022
Carlos Guijas and coworkers at Scripps recently found that the leukotriene antagonist and antiasthmatic agent zafirlukast was able to differentiate adipocyte precursors into functional brown adipocytes. […]
