June 27, 2024
Focus on Bioactive Natural Products: Verrucarin A, a structurally intriguing natural product produced by soil microbe Myrothecium spp. was shown by Kondo et al. to attenuate […]
June 27, 2024
Focus on Bioactive Natural Products: Just out in ACS Chemical Biology, FA Gowans and coworkers at Berkeley reported that ophiobolin A (OPA) covalently targets mitochondrial complex […]
June 14, 2024
Beauvericin, a mycotoxin produced by various Fusarium spp, is an important food and animal feed contaminant. Its diverse toxic activities coupled with its ability to cross […]
June 12, 2024
An interesting review has just been published in the May 23 issue of Cell by A Suomalainen and J Nunnari entitled “Mitochondria at the Crossroads of […]
June 12, 2024
In a paper just out in Nature Aging, Goro Katsuumi and coworkers in Tokyo demonstrated that inhibition of sodium-glucose co-transporter 2 (SGLT2) with canagliflozin enhanced clearance […]
March 29, 2024
Last week the FDA approved Italfarmaco’s givinostat (ITF2357) for Duchenne muscular dystrophy. Givinostat is a novel histone deacetylase (HDAC) inhibitor and was approved for DMD patients […]
March 26, 2024
Focus Biomolecules will be exhibiting at the annual meeting of American Association for Cancer Research (AACR) in San Diego, April 7 – 10. Stop by our […]
March 15, 2024
New DUB inhibitor: Deubiquitinating enzymes, or DUBs, are proteases that regulate ubiquitination dynamics. DUBs have become promising targets for drug discovery across diverse therapeutic areas. For […]
March 7, 2024
Journal Club: In the January issue of J. Cellular Physiology, Arasaki and Hayata from the Tokyo University of Science studied the mechanisms of nuclear localization of […]
