Focus on Drug Discovery: Saridegib is a natural product-inspired drug candidate. Its prototype, cyclopamine was discovered as a teratogenic steroidal alkaloid that was found to cause […]
Journal Club: Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder caused by the expression of progerin, a Lamin A mutant. The study of HGPS […]
Journal Club: In a paper just out in PNAS, Y. Lin and coworkers showed that Eltrombopag, an FDA-approved drug for thrombocytopenia, inhibits autophagy by targeting the […]
In The News: Bempedoic acid is an FDA-approved drug for the treatment of hypercholesterolemia sold under the brand name Nexletol. It is an ATP citrate lyase […]
J Zhang and coworkers at Leiden University Med Ctr have shown that a splice variant of the ubiquitin specific protease, USP19-CY, can enhance the epithelial-mesenchymal transition […]
In a paper just out in Phytomedicine, HG Kim and coworkers describe the in vitro anti-cancer activity of Beauvericin, an antimicrobial metabolite from the fungus Beauveria […]
Resorcylic acid lactones are a diverse family of fungal natural products which possess a variety of useful pharmacological activities. For example: Radicicol Hypothemycin and others are […]
Apoptolidin is a novel microbial natural product isolated from Nocardiopsis sp. It was shown to be a powerful inducer of apoptosis in a variety of cancer […]
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