Activation of autophagy is a novel mode of therapeutic intervention and offers the possibility of developing new “host-directed” therapeutics against mycobacterial infection. For example, Kim et […]
Paula Juricic and coworkers at the Max Planck Institute for Biology of Ageing report in a recent issue of Nature Aging that a brief early treatment […]
Robert Prior and coworkers report in a recent issue of Molecular Neurobiology that inhibition of HDAC3 with RGFP966, a highly selective HDAC3 inhibitor, stimulates myelination in […]
JM Snyder and coworkers report in the August issue of Geroscience that canagliflozin, a clinically important anti-diabetic agent, results in a 14% increase in median lifespan […]
Chroman 1 is an important new small molecule tool for the generation and maintenance of stem cells. An extremely potent (1 pM) inhibitor of Rho kinase […]
In a recent paper in Cell Research, Li and coworkers explored the nuclear function of RIPK1 and demonstrated that RIPK1 phosphorylates a key component of the […]
In the August issue of J. Antibiotics (Tokyo) Yoshida and coworkers at the University of Tsukuba reviewed their excellent work on synthesis, SAR, biology and chemical […]
Yan and coworkers have demonstrated a potential way to boost innate immune attack on solid tumors. They found that Rocaglamide, a structurally novel natural product, promoted […]
Mitapivat is an allosteric activator of red blood cell pyruvate kinase, the enzyme that performs the final step of glycolysis: it catalyzes the conversion of phosphoenolpyruvate […]
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