March 23, 2023
Journal Club: In a paper just out in PNAS, Y. Lin and coworkers showed that Eltrombopag, an FDA-approved drug for thrombocytopenia, inhibits autophagy by targeting the […]
March 23, 2023
Journal Club: A paper just out in J. Proteomics by Herman Sintim and coworkers at Purdue sheds new light on the signaling roles of the cyclic […]
March 23, 2023
In The News: Bempedoic acid is an FDA-approved drug for the treatment of hypercholesterolemia sold under the brand name Nexletol. It is an ATP citrate lyase […]
February 10, 2023
J Zhang and coworkers at Leiden University Med Ctr have shown that a splice variant of the ubiquitin specific protease, USP19-CY, can enhance the epithelial-mesenchymal transition […]
January 25, 2023
In a paper just out in Phytomedicine, HG Kim and coworkers describe the in vitro anti-cancer activity of Beauvericin, an antimicrobial metabolite from the fungus Beauveria […]
January 13, 2023
Resorcylic acid lactones are a diverse family of fungal natural products which possess a variety of useful pharmacological activities. For example: Radicicol Hypothemycin and others are […]
January 9, 2023
Apoptolidin is a novel microbial natural product isolated from Nocardiopsis sp. It was shown to be a powerful inducer of apoptosis in a variety of cancer […]
December 22, 2022
In a recent paper in Nature, Bryan Roth et al. revealed detailed features in the recognition of DREADD actuators by designer receptors. Muscarinic DREADDs or designer […]
December 15, 2022
Urolithin A is a microbial metabolite of dietary ellagitannins produced in the gut. It has been shown to induce mitophagy and prolong lifespan in C. elegans […]
