Filipin III is a microbial natural product isolated from Streptomyces filipinensis. It is an important fluorescent probe for cellular cholesterol detection. In addition, because it binds […]
Two recent papers employed Sinefungin in determination of the structure of two different viral methyltransferases. Sinefungin is a Streptomyces natural product analog of S-adenosylmethionine acting as […]
In a molecular docking analysis, Tronco Pauletto et al. found that antidepressants such as fluoxetine, citalopram, and norfluoxetine likely interact with and disrupt SARS-CoV-2 main protease […]
Carlos Guijas and coworkers at Scripps recently found that the leukotriene antagonist and antiasthmatic agent zafirlukast was able to differentiate adipocyte precursors into functional brown adipocytes. […]
Yuki Yoshimatsu and coworkers have shown that they could establish patient-derived cancer cell lines for myxofibrosarcoma and pleomorphic sarcoma. After screening these cell lines with a […]
P. Hiengrach and coworkers recently showed that BAM15, a mitochondrial uncoupling agent, attenuated sepsis in a mouse cecal ligation and puncture model. BAM15 attenuated sepsis as […]
Activation of autophagy is a novel mode of therapeutic intervention and offers the possibility of developing new “host-directed” therapeutics against mycobacterial infection. For example, Kim et […]
Paula Juricic and coworkers at the Max Planck Institute for Biology of Ageing report in a recent issue of Nature Aging that a brief early treatment […]
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