Cancer cells modify their metabolism in order to survive and grow. For example, they employ the Warburg effect (increasing glucose uptake and directly converting it to […]
Lipid raft dynamics regulate signaling for multiple cellular functions, such as apoptosis, proliferation, and differentiation. They reside in the plasma membrane and comprise sphingolipids, cholesterol, and […]
Kumar et al. and Zijlmans et al. have published in Nature Cell Biology that Polycomb repressive complex 2 (PRC2) epigenetically reduces lineage potential of hESCs. They […]
JTE-607, a cell-permeable prodrug which is converted to its active COOH form via intracellular esterases, was originally found to inhibit cytokine release but its mechanism of […]
A team headed by distinguished neuroscientist Alcino Silva recently showed that expression of C-C chemokine receptor type 5 (CCR5) expression reduced memory recall, and maraviroc (Focus […]
Perylenequinones are a family of structurally novel fungal or plant natural products which act as photosensitizers. They absorb light energy, enabling them to generate reactive oxygen […]
In Nature Communications, Zhang et al. show that DJ001, a selective allosteric inhibitor of protein tyrosine phosphatase sigma (PTPσ), promotes hematopoietic stem cell (HSC) regeneration. Treatment […]
In a fascinating paper just out in Cell Metabolism, Mathias Wenes and coworkers found that the mitochondrial pyruvate carrier (MPC) regulates memory T cell differentiation and […]
CHIR-99021 is another popular tool for stem cell maintenance which increases cell survival and proliferation. It is a GSK3β inhibitor, and Komiya et al. used CHIR-99021 […]
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