Chaperones

Molecular chaperones are proteins that aid in the folding of newly synthesized polypetide chains and translocation of proteins across membranes. Heat shock proteins such as HSP70 and HSP90 have important roles in proteostasis and protein folding ( and thus function), transportation (and thus location in the cell), and proper degradation. Dysfunctioning chaperones play roles in neurodegeneration, cancer, and autoimmune disease.

Folding Enzymes

  • Cycloheximide-N-ethylethanoate | FKBP12 inhibitor
    Catalog Number:
    10-1062
    Activity:
    FKBP12 inhibitor
    Chemical Name:
    Ethyl 2-(4-((R)-2-((1S, 3S, 5S)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-2,6-dioxopiperidin-1-yl)acetate
    Molecular Weight:
    367.44
    Molecular Formula:
    C19H29NO6
    Solubility:
    Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 3 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Folding Enzymes Products

Heat Shock Proteins

  • Luminespib | HSP90 inhibitor
    CAS:
    747412-49-3
    Catalog Number:
    10-4672
    Activity:
    HSP90 inhibitor
    Chemical Names:
    5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide
    Alternate Name:
    NVP-AUY922; VER-52296
    Molecular Weight:
    465.54
    Molecular Formula:
    C26H31N3O5
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • BGP-15 | Cellular protectant
    CAS:
    66611-37-8
    Catalog Number:
    10-1373
    Activity:
    Cellular protectant
    Chemical Names:
    N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide, dihydrochloride
    Molecular Weight:
    351.28
    Molecular Formula:
    C14H22N4O2·2HCl
    Solubility:
    Soluble in Water (70 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at room temperature for up to 1 month.
    Shipping Code:
    RT
  • KNK437 | HSP70 inhibitor
    CAS:
    218924-25-5
    Catalog Number:
    10-5561
    Activity:
    HSP70 inhibitor
    Chemical Names:
    3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde
    Molecular Weight:
    245.23
    Molecular Formula:
    C13H11NO4
    Solubility:
    Soluble in DMSO (30 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • CCT251236 | HSF1 inhibitor
    CAS:
    1693731-40-6
    Catalog Number:
    10-4410
    Activity:
    Heat Shock Transcription Factor 1 stress pathway inhibitor
    Chemical Names:
    N-[5-(2,3-Dihydro-1,4-benzodioxine-6-carbonylamino)-2-methylphenyl]-2-(2-pyrrolidin-1-ylethoxy)quinoline-6-carboxamide
    Molecular Weight:
    552.63
    Molecular Formula:
    C32H32N4O5
    Solubility:
    Soluble in DMSO (5 mg/ml)
    Physical Properties:
    Off-white/beige solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Ganetespib | HSP90 inhibitor
    CAS:
    888216-25-9
    Catalog Number:
    10-4474
    Activity:
    HSP90 inhibitor
    Chemical Name:

    3-(2,4-Dihydroxy-5-propan-2-ylphenyl)-4-(1-methylindol-5-yl)-1H-1,2,4-triazol-5-one;

    Molecular Weight:
    364.40
    Molecular Formula:
    C20H20N4O3
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Heat Shock Proteins Products

Other Chaperones

  • Migalastat HCl | Galactosidase inhibitor/Pharmacological chaperone
    CAS:
    75172-81-5
    Catalog Number:
    10-2632
  • Honokiol-DCA | TRAP1 Inhibitor
    CAS:
    1620160-42-0
    Catalog Number:
    10-3596
  • CBL0137 | Inhibitor of the histone chaperone FACT
    CAS:
    1197996-80-7
    Catalog Number:
    10-4026
  • AR7 | Activates chaperone mediated autophagy
    CAS:
    80306-38-3
    Catalog Number:
    10-5515
    Activity:
    Activates chaperone mediated autophagy
    Chemical Names:
    7-Chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine
    Molecular Weight:
    257.72
    Molecular Formula:
    C15H12ClNO
    Solubility:
    Soluble in DMSO (30 mg/ml)
    Physical Properties:
    Pale pink solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Lycorine HCl | Protein synthesis inhibitor/SCAP degrader
    CAS:
    2188-68-3
    Catalog Number:
    10-2608
    Activity:
    Protein synthesis inhibitor/SCAP degrader
    Chemical Names:
    Galanthidine; Amarylline; Narcissine
    Molecular Weight:
    323.77
    Molecular Formula:
    C16H17NO4·HCl
    Solubility:
    Soluble in water (15 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Other Chaperones Products

Sigma Receptor

  • PB28 dihydrochloride | Potent sigma2 agonist
    CAS:
    172907-03-8
    Catalog Number:
    10-4665
    Activity:
    High affinity sigma2 ligand
    Chemical Names:
    1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine dihydrochloride
    Molecular Weight:
    443.50
    Molecular Formula:
    C24H38N2O
    Solubility:
    Soluble in DMSO (>25 mg/ml) or water (5 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • SA4503 | Potent and selective sigma-1 agonist
    CAS:
    165377-44-6
    Catalog Number:
    10-4219
    Activity:
    Potent and selective sigma-1 agonist
    Chemical Name:
    1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
    Alternate Name:
    Cutamesine
    Molecular Weight:
    441.43
    Molecular Formula:
    C23H32N2O2 • 2HCl
    Solubility:
    Soluble in DMSO (up to 5 mg/ml) or in Water (up to at least 25 mg/ml)..
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20° (des.)
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Pridopidine | Sigma-1 ligand Neuroprotectant/Neurorestorative
    CAS:
    346688-38-8
    Catalog Number:
    10-4003
    Activity:
    Sigma-1 ligand Neuroprotectant Neurorestorative
    Chemical Name:
    4-(3-(Methylsulfonyl)phenyl)-1-propylpiperidine
    Alternate Name:
    ACR16
    Molecular Weight:
    281.41
    Molecular Formula:
    C15H23NO2S
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    >98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • BD1047 dihydrobromide | Selective sigma-1 antagonist
    CAS:
    138356-21-5
    Catalog Number:
    10-4210
    Activity:
    Selective sigma-1 antagonist
    Chemical Name:
    N-[2-(3,4Dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide
    Molecular Weight:
    437.04
    Molecular Formula:
    C13H20Cl2N2 • 2HBr
    Solubility:
    Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • BD1063 dihydrochloride | Selective sigma-1 antagonist
    CAS:
    206996-13-6
    Catalog Number:
    10-4211
    Activity:
    Selective sigma-1 antagonist
    Chemical Name:
    1-[2-(3,4-Dichlorophenyl)ethyl]-4-methylpiperazine dihydrochloride
    Molecular Weight:
    346.13
    Molecular Formula:
    C13H18Cl2N2 • 2HCl
    Solubility:
    Soluble in Water (up to at least 25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Sigma Receptor Products

Small Molecule Chaperones

  • Isofagomine tartrate | Glucocerebrosidase activator and chaperone
    CAS:
    957230-65-8
    Catalog Number:
    10-2859
    Activity:
    Glucocerebrosidase activator and chaperone
    Chemical Name:
    (3R,4R,5R)-5-Hydroxymethyl-3,5-piperidinediol tratrate
    Molecular Weight:
    297.26
    Molecular Formula:
    C6H13NO3 • C4H6O6
    Solubility:
    Soluble in DMSO (up to 2 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Small Molecule Chaperones Products

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