Cholesterol and Analogues

Cholesterol and its analogues are sterols that function as critical components of the plasma membrane, the basis for bile, and building blocks for steroid hormones and Vitamin D. Because these molecules are necessary for proper functioning of cells and organisms, manipulation of their synthesis, metabolism, and signaling are important areas of cellular signaling research.

Biosynthesis Inhibitors

  • Bempedoic acid | ATP citrate lyase inhibitor
    CAS:
    738606-46-7
    Catalog Number:
    10-4114
  • Hymeglusin | Mevalonate biosynthesis inhibitor
    CAS:
    29066-42-0
    Catalog Number:
    10-3289
    Activity:
    Melvalonate biosynthesis inhibitor
    Chemical Name:
    11-[3R-(Hydroxymethyl)-4-oxo-2R-oxetanyl]-3,5,7R-trimethyl-2E,4E-undecadienoic acid
    Alternate Names:
    L-659699; Antibiotic 1233A; Antibiotic F244
    Molecular Weight:
    324.41
    Molecular Formula:
    C18H28O5
    Solubility:
    Soluble in DMSO (up to 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    96% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Fluvastatin Na | HMG CoA reductase inhibitor
    CAS:
    93957-55-2
    Catalog Number:
    10-2554
    Activity:
    HMG CoA reductase inhibitor
    Chemical Name:
    (+/-)(3R*,5S*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt
    Molecular Weight:
    466.45
    Molecular Formula:
    C24H25FNO4 . Na
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Water (up to 10 mg/ml)
    Physical Properties:
    Tan solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Itraconazole | Autophagy inducer / Inhibits glioblastoma growth
    CAS:
    84625-61-6
    Catalog Number:
    10-2033
    Activity:
    Autophagy inducer / Inhibits glioblastoma growth
    Alternate Names:
    Oriconazole; R51211
    Molecular Weight:
    705.63
    Molecular Formula:
    C35H36Cl2N8O4
    Solubility:
    Soluble in DMSO (up to 1.5 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • AK-7 | SIRT2 inhibitor
    CAS:
    420831-40-9
    Catalog Number:
    10-1429
    Activity:
    SIRT2 inhibitor
    Chemical Name:
    3-(1-Azepanylsulfonyl)-N-(3-bromophenyl)benzamide
    Molecular Weight:
    437.36
    Molecular Formula:
    C19H21BrN2O3S
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 8 mg/ml with warming).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Biosynthesis Inhibitors Products

Metabolites

  • 7-Dehydrocholesterol | Ferroptosis inhibitor
    CAS:
    434-16-2
    Catalog Number:
    10-3941
  • 5alpha,6alpha-Epoxycholesterol | LXR ligand
    CAS:
    1250-95-9
    Catalog Number:
    10-4545
    Activity:
    LXR ligand
    Chemical Name:
    Cholestan-5α,6α-epoxy-3β-ol
    Molecular Weight:
    402.65
    Molecular Formula:
    C27H46O2
    Solubility:
    Soluble in DMSO (up to 10 mg/ml) orin Ethanol (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • 7α-Hydroxycholesterol | Bile acid precursor
    CAS:
    566-26-7
    Catalog Number:
    10-4538
    Activity:
    Bile acid precursor
    Chemical Name:
    5-Cholesten-3β, 7α-diol
    Molecular Weight:
    402.66
    Molecular Formula:
    C27H46O2
    Solubility:
    Soluble in DMSO or in Ethanol.
    Physical Properties:
    White or pale yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • 25-Hydroxycholesterol | Biologically active cholesterol metabolite
    CAS:
    2140-46-7
    Catalog Number:
    10-4539
    Activity:
    Biologically active cholesterol metabolite
    Chemical Name:
    5-Cholesten-3β, 25-diol
    Molecular Weight:
    402.66
    Molecular Formula:
    C27H46O2
    Solubility:
    Soluble in DMSO or in Ethanol.
    Physical Properties:
    White or pale yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • 20(S)-Hydroxycholesterol | Smoothened activator
    CAS:
    516-72-3
    Catalog Number:
    10-4540
    Activity:
    Smoothened activator
    Chemical Name:
    5-Cholesten-3β, 20α-diol
    Molecular Weight:
    402.66
    Molecular Formula:
    C27H46O2
    Solubility:
    Soluble in DMSO or in Ethanol.
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Metabolites Products

Other Cholesterol

  • 7-Dehydrocholesterol | Ferroptosis inhibitor
    CAS:
    434-16-2
    Catalog Number:
    10-3941
  • Ezetimibe | Cholesterol absorption inhibitor
    CAS:
    163222-33-1
    Catalog Number:
    10-2027
    Activity:
    Cholesterol absorption inhibitor
    Chemical Name:
    (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidine-2-one
    Alternate Names:
    SCH 58235; Ezetrol
    Molecular Weight:
    409.43
    Molecular Formula:
    C24H21F2NO3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml)
    Physical Properties:
    White or off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Filipin III | Cholesterol probe
    CAS:
    480-49-9
    Catalog Number:
    10-1490
    Activity:
    Cholesterol probe
    Source:
    Isolated from Streptomyces filipinensis
    Molecular Weight:
    654.85
    Molecular Formula:
    C35H58O11
    Solubility:
    Soluble in Methanol (up to 10 mg/ml)
    Physical Properties:
    White or light yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in methanol may be stored under inert gas at -20°C for up to 2 months.
    Shipping Code:
    RT
  • TRO19622 | Neurotrophic agent
    CAS:
    22033-87-0
    Catalog Number:
    10-3230
    Activity:
    Neurotrophic agent
    Chemical Name:
    Cholest-4-en-3-one oxime
    Alternate Names:
    Olesoxime
    Molecular Weight:
    399.65
    Molecular Formula:
    C27H45NO
    Solubility:
    Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • RVX-208 | BET bromodomain inhibitor
    CAS:
    1044870-39-4
    Catalog Number:
    10-1487
    Activity:
    BET bromodomain inhibitor
    Chemical Name:
    2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-4(3H)-quinzolinone
    Molecular Weight:
    370.41
    Molecular Formula:
    C20H22N2O5
    Solubility:
    Soluble in DMSO (up to 75 mg/ml) or in Ethanol (up to 4 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All Other Cholesterol Products

Trafficking

  • T0901317 | LXR Agonist
    CAS:
    293754-55-9
    Catalog Number:
    10-3361
  • Probucol | Antioxidant hypercholesterolemic agent
    CAS:
    23288-49-5
    Catalog Number:
    10-2679
  • Autogramin-2 | Autophagy blocker / GRAMD1A inhibitor
    CAS:
    2375541-45-8
    Catalog Number:
    10-4439
    Activity:
    Autophagy blocker / GRAMD1A inhibitor
    Chemical Name:

    t-Butyl 2-[(4-propan-2-yloxybenzoyl)amino]-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-5-carboxylate

    Molecular Weight:
    417.53
    Molecular Formula:
    C21H27N3O4S
    Solubility:
    Soluble in DMSO (up t0 25 mg/ml) or in Ethanol (up to 25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Leelamine | Intracellular cholesterol transport inhibitor
    CAS:
    16496-99-4
    Catalog Number:
    10-2955
    Activity:
    Intracellular cholesterol transport inhibitor
    Chemical Name:
    (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride
    Alternate Name:
    Lylamine HCl; (+)-Dehydroabietylamine HCl
    Molecular Weight:
    321.93
    Molecular Formula:
    C20H31N•HCl
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Water (up to 9 mg/ml).
    Physical Properties:
    Off-white or beige solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Itraconazole | Autophagy inducer / Inhibits glioblastoma growth
    CAS:
    84625-61-6
    Catalog Number:
    10-2033
    Activity:
    Autophagy inducer / Inhibits glioblastoma growth
    Alternate Names:
    Oriconazole; R51211
    Molecular Weight:
    705.63
    Molecular Formula:
    C35H36Cl2N8O4
    Solubility:
    Soluble in DMSO (up to 1.5 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Trafficking Products

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