Nitric oxide and other gaseous mediators

Nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H2S), and other gases play important roles in vascular tone, innate immunity, inflammation, and other processes. As these gases are difficult to use in a research setting, many types of small molecules have been created that act as donors of the required gases under physiological conditions.

H2S

  • AP39 | Mitochondrial-targeted hydrogen sulfide donor
    CAS:
    1429173-57-8
    Catalog Number:
    10-3916
    Activity:
    Mitochondrial targeted hydrogen sulfide donor
    Chemical Names:
    (10-Oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide
    Molecular Weight:
    721.77
    Molecular Formula:
    C37H38BrO2PS3
    Solubility:
    Soluble in DMSO (at least 35 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. Hygroscopic! Protect from moisture and air.
    Shipping Code:
    RT
  • GYY4137 | Hydrogen sulfide donor
    CAS:
    106740-09-4
    Catalog Number:
    10-4507
    Activity:
    Hydrogen sulfide donor
    Chemical Names:
    Morpholine (4-methoxyphenyl)(morpholino)phosphinodithioate
    Molecular Weight:
    376.47
    Molecular Formula:
    C15H25N2O3PS2
    Solubility:
    Soluble in DMSO (>25 mg/ml); Water (25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% NMR
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Make solutions fresh daily – GYY4137 starts to react immediately with water.
    Shipping Code:
    RT
  • Propargylglycine | H2S synthase inhibitor
    CAS:
    64165-64-6
    Catalog Number:
    10-1366
    Activity:
    H2S synthase inhibitor
    Chemical Name:
    2-Amino-4-pentynoic acid
    Molecular Weight:
    113.12
    Molecular Formula:
    C5H7NO2
    Solubility:
    Soluble in DMSO (up to 10 mg/ml) or in Water (up tp 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All H2S Products

NO donors

  • DEA NONOate | NO Donor
    CAS:
    372965-00-9
    Catalog Number:
    10-4547
    Activity:
    NO Donor
    Chemical Name:
    2-(N,N-Diethylamino)-diazenolate-2-oxide diethylammonium salt
    Molecular Weight:
    206.29
    Molecular Formula:
    C4H10N3O2 • C4H12N
    Solubility:
    Soluble in Water or Ethanol
    Physical Properties:
    Off-white solid
    Purity:
    97% by NMR
    (1H-NMR)
    Storage Temperature:
    -80°C
    Stability:
    Stable for 1 year from date of purchase s supplied. Protect from exposure to air or moisture. Solutions are not stable and must be prepared immediately before use. See the product description for information on half-life in solution.
    Shipping Code:
    Blue Ice
  • Spermine NONOate | NO Donor
    CAS:
    136587-13-8
    Catalog Number:
    10-4549
    Activity:
    NO Donor
    Chemical Name:
    1-{N-[3-Aminopropyl]-N-[4-(3-aminopropylammonio)butyl]-amino}-diazen-1-ium-1,2-diolate
    Molecular Weight:
    262.35
    Molecular Formula:
    C10H26N6O2
    Solubility:
    Soluble in Water or Ethanol
    Physical Properties:
    Off-white solid
    Purity:
    97% by (1H-NMR)
    Storage Temperature:
    -80°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Protect from exposure to air or moisture. Buffer solutions are not stable and must be prepared immediately before use.
    Shipping Code:
    Blue Ice
  • PAPA NONOate | NO Donor
    CAS:
    146672-58-4
    Catalog Number:
    10-4548
    Activity:
    NO Donor
    Chemical Name:
    N-[3-Aminopropyl(propyl)amino]-N-hydroxynitrous amide
    Molecular Weight:
    176.22
    Molecular Formula:
    C6H16N4O2
    Solubility:
    Soluble in Water or Ethanol.
    Physical Properties:
    Off-white solid
    Purity:
    97% by (1H-NMR)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Protect from exposure to air or moisture. Solutions are not stable and must be prepared immediately before use.
    Shipping Code:
    Blue Ice
  • DETA NONOate | NO Donor
    CAS:
    146724-94-9
    Catalog Number:
    10-4527
    Activity:
    NO Donor
    Alternate Names:
    Diethylenetriamine NONOate
    Chemical Name:
    N-[bis(2-Aminoethyl)amino]-N-hydroxynitrus amide
    Molecular Weight:
    163.18
    Molecular Formula:
    C4H13N5O2
    Solubility:
    Soluble in Water.
    Physical Properties:
    Solid
    Purity:
    97% by (1H-NMR)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Store under inert gas. Solutions must be made fresh immediately before use and cannot be stored.
    Shipping Code:
    Blue Ice
View All NO donors Products

NOS

  • 1400W | iNOS inhibitor
    CAS:
    214358-33-5
    Catalog Number:
    10-4501
    Activity:
    iNOS inhibitor
    Chemical Name:
    N-(3-Aminomethyl)benzyl)acetamidine dihydrochloride
    Molecular Weight:
    250.17
    Molecular Formula:
    C10H15N3 2HCl
    Solubility:
    Soluble in Water (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year as supplied. Solutions are not stable. Solutions must be prepared fresh and used within one working day.
    Shipping Code:
    RT
  • TRIM | Nitric oxide synthase inhibitor
    CAS:
    25371-96-4
    Catalog Number:
    10-2699
    Activity:
    Nitric oxide synthase inhibitor
    Chemical Name:
    1-(2-Trifluoromethylphenyl)imidazole
    Molecular Weight:
    212.18
    Molecular Formula:
    C107F3N2
    Solubility:
    Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 20 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All NOS Products

Peroxynitrite

  • SIN-1 | Peroxynitrite Donor
    CAS:
    16142-27-1
    Catalog Number:
    10-1547
    Activity:
    Peroxynitrite donor
    Chemical Name:
    Amino-3-morpholinyl-1,2,3-oxadiazolium chloride
    Alternate Name:
    3-Morpholinylsydnonimine chloride
    Molecular Weight:
    206.63
    Molecular Formula:
    C6H11ClN4O2
    Solubility:
    Soluble in DMSO (up to 35 mg/ml) or in Water (up to 65 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions must be prepared fresh and cannot be stored.
    Shipping Code:
    RT
  • Trolox | Antioxidant
    CAS:
    53188-07-1
    Catalog Number:
    10-2393
    Activity:
    Antioxidant
    Chemical Name:
    6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
    Molecular Weight:
    250.3
    Molecular Formula:
    C14H18O4
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). Also soluble in Water at alkalinepH.
    Physical Properties:
    Off-white solid
    Purity:
    97% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Ebselen | Glutathione peroxidase mimic
    CAS:
    60940-34-3
    Catalog Number:
    10-2288
    Activity:
    Glutathione peroxidase mimic
    Alternate Names:
    PZ-51
    Chemical Name:
    2-Phenyl-1,2-benzisoselenazol-3(2H)-one
    Molecular Weight:
    274.18
    Molecular Formula:
    C13H9NOSe
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml with warming).
    Physical Properties:
    Light yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • MnTBAP | SOD mimetic
    CAS:
    55266-18-7
    Catalog Number:
    10-1386
    Activity:
    SOD mimetic
    Chemical Name:
    Mn(III) meso-Tetra(4-carboxyphenyl)porphine chloride
    Molecular Weight:
    879.17
    Molecular Formula:
    C48H28MnN4O8 Cl
    Solubility:
    Soluble in 0.1M NaOH
    Physical Properties:
    Black solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in 0.1M NaOH may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All Peroxynitrite Products

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