Kinases

  • SMI-4a | PIM1 inhibitor

    CAS:
    438190-29-5
    Catalog Number:
    10-1359
    Activity:
    PIM1 inhibitor
    Chemical Name:
    5-(3-Trifluoromethylbenzylidene)thiazolidine
    Molecular Weight:
    273.23
    Molecular Formula:
    C11H6F3NO2S
    Solubility:
    Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 40 mg/ml with warming).
    Physical Properties:
    Tan solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
    From $60.00
  • SNS-314 mesylate | Aurora kinase inhibitor

    CAS:
    1146618-41-8
    Catalog Number:
    10-4779
    Activity:
    Aurora kinase inhibitor
    Chemical Name:
    1-(3-Chlorophenyl)-3-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl]urea mesylate
    Molecular Weight:
    527.04
    Molecular Formula:
    C18H15ClN6OS2 • CH3SO3H
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
    From $70.00
  • Sorafenib | Multi-kinase inhibitor

    CAS:
    475207-59-1
    Catalog Number:
    10-2174
    Activity:
    Inhibitor of Raf-1 and other kinases
    Alternate Names:
    BAY 43-9006
    Chemical Name:
    4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide
    Molecular Weight:
    464.83
    Molecular Formula:
    C21H16ClF3N4O3
    Solubility:
    Soluble in DMSO (up to 200 mg/ml) or in Ethanol (up to 3 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
    From $40.00
  • SU-1498 | VEGFR kinase inhibitor

    CAS:
    168835-82-3
    Catalog Number:
    10-2074
    Activity:
    VEGFR kinase inhibitor
    Chemical Name:
    (E)-N-(3′-Phenylpropyl)-α-cyano-3′,5′-diisopropyl-4′-hydroxycinnamamide
    Molecular Weight:
    390.52
    Molecular Formula:
    C25H30N2O2
    Solubility:
    Soluble in DMSO.
    Physical Properties:
    Pale yellow solid
    Purity:
    98%
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
    From $55.00
  • SU-5402 | FGFR Phosphorylation inhibitor

    CAS:
    215543-92-3
    Catalog Number:
    10-2520
    Activity:
    FGFR Phosphorylation inhibitor
    Alternate Names:
    PF-02969207
    Chemical Name:
    3-[4-Methyl-2-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid
    Molecular Weight:
    296.32
    Molecular Formula:
    C17H16N2O3
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    Orange solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
    From $70.00
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