July 14, 2026
In a paper just out in Redox Biology, the authors show that inhibition of 15-OH-PGDH with SW033291 restores redox homeostasis and confers neuroprotection in Parkinson’s disease. […]
February 11, 2026
FOCUS on Parkinson’s Disease: Y Xu and coworkers identified deubiquitinating enzyme USP25 as a susceptible locus for PD as just reported in PNAS. They showed that USP25 […]
January 20, 2026
FOCUS on Alzheimer’s disease. A recent paper by AA Pieper and colleagues demonstrated that pharmacologic restoration of NAD+ homeostasis with P7C3-A20 reverses cognitive deficits and neuropathology […]
November 5, 2025
FOCUS on Drug Failures. The FDA rejected Biohaven’s glutamate modulator Troriluzole for treatment of spinocerebellar ataxia, a rare and life-threatening neurodegenerative disease with no treatment options. […]
March 20, 2025
FOCUS on drug failures. Denali Therapeutics‘ experimental drug for Amyotrophic Lateral Sclerosis (ALS) has taken another setback as the drug generated disappointing results in a phase […]
February 3, 2025
Focus on drug discovery failure. Development of Risvodetinib for Parkinson’s disease was halted following disappointing Phase II results. The drug, which is a potent, brain-penetrant c-Abl […]
November 19, 2024
Is coffee good for your brain? N-Eicosanoyl-serotonin (EHT), a novel natural product found in coffee, has been shown to have a protective effect in models of […]
June 27, 2024
Focus on Bioactive Natural Products: Verrucarin A, a structurally intriguing natural product produced by soil microbe Myrothecium spp. was shown by Kondo et al. to attenuate […]