Approved Drugs
Drugs approved by the FDA or other agencies for use in medicine are excellent tools for research because they are demonstrated to have good absorption (bioavailable), distribution and activity, and pharmacokinetics for use in vivo experiments. They are used in cells or animals for basic research, and for drug discovery (repurposing, benchmarking and other applications).
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Baricitinib | JAK 1/2 inhibitor
From $48.00CAS:1187594-09-7Catalog Number:10-3893Activity:JAK 1/2 inhibitorChemical Name:1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidine-acetonitrileAlternate Name:INCB028050; LY3009104Molecular Weight:371.42Molecular Formula:C16H17N7O2SSolubility:Soluble in DMSO (up to 30 mg/ml) or in DMF (up to 50 mg/ml).Physical Properties:White or off-white solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.Shipping Code:RT -
Bedaquiline | Antituberculosis agent/bacterial ATP synthase inhibitor
From $50.00CAS:843663-66-1Catalog Number:10-4403Activity:Antituberculosis agent/Bacterial ATP synthase inhibitorChemical Names:(1R,2S)-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-oAlternate Name:TMC207; R207910Molecular Weight:555.50Molecular Formula:C32H31BrN2O2Solubility:Soluble in DMSO (10 mg/ml)Physical Properties:White solidPurity:99% HPLC
NMR (Conforms)Storage Temperature:Room temperatureStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT -
Bepridil | Calcium channel blocker\Active against SARS-CoV2
From $40.00CAS:74764-40-2Catalog Number:10-4958Activity:Calcium channel blocker/anti-SARS-CoV2Chemical Name:N-Benzyl-N-[3-(2-methylpropoxy)-2-pyrrolidin-1-ylpropyl]aniline hydrochlorideMolecular Weight:403.00Molecular Formula:C24H34N2O·HClSolubility:Soluble in DMSO (up to 25 mg/ml) or ethanol (up to 25 mg/ml)Physical Properties:White solidPurity:>98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.Shipping Code:RT -
Bexarotene | Retinoid RXR agonist
From $40.00CAS:153559-49-0Catalog Number:10-2121Activity:Retinoid RXR agonistAlternate Names:LGD-1069, SR-11247Chemical Name:4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acidMolecular Weight:348.49Molecular Formula:C24H28O2Solubility:Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 10 mg/ml with warming).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.Shipping Code:RT -
Binimetinib | MEK1/2 inhibitor
From $45.00CAS:606143-89-9Catalog Number:10-4789Activity:MEK1/2 inhibitorChemical Name:6-(4-Bromo-2-fluoroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamideAlternate Names:ARRY-162; MEK162Molecular Weight:441.23Molecular Formula:C17H15BrF2N4O3Solubility:Soluble in DMSO (up to at least 25 mg/ml)Physical Properties:White solidPurity:99% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT
