Sigma receptor

Sigma receptors, originally thought to be a type of opioid receptor, are non-GPCR transmembrane proteins expressed mainly in the endoplasmic reticulum and associated with the mitochondria. There are two receptor subtypes, σ1 and σ2, that act as chaperone proteins that modulate several physiological pathways involved in Er stress and Ca2+ homeostasis. Modulators of these receptors have been shown to have neuroprotective, antiproliferative, and antinociceptive effects.

Agonists

  • PB28 dihydrochloride | Potent sigma2 agonist
    CAS:
    172907-03-8
    Catalog Number:
    10-4665
    Activity:
    High affinity sigma2 ligand
    Chemical Names:
    1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine dihydrochloride
    Molecular Weight:
    443.50
    Molecular Formula:
    C24H38N2O
    Solubility:
    Soluble in DMSO (>25 mg/ml) or water (5 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • SA4503 | Potent and selective sigma-1 agonist
    CAS:
    165377-44-6
    Catalog Number:
    10-4219
    Activity:
    Potent and selective sigma-1 agonist
    Chemical Name:
    1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
    Alternate Name:
    Cutamesine
    Molecular Weight:
    441.43
    Molecular Formula:
    C23H32N2O2 • 2HCl
    Solubility:
    Soluble in DMSO (up to 5 mg/ml) or in Water (up to at least 25 mg/ml)..
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20° (des.)
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Pridopidine | Sigma-1 ligand Neuroprotectant/Neurorestorative
    CAS:
    346688-38-8
    Catalog Number:
    10-4003
    Activity:
    Sigma-1 ligand Neuroprotectant Neurorestorative
    Chemical Name:
    4-(3-(Methylsulfonyl)phenyl)-1-propylpiperidine
    Alternate Name:
    ACR16
    Molecular Weight:
    281.41
    Molecular Formula:
    C15H23NO2S
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    >98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Siramesine | Selective sigma-2 agonist
    CAS:
    147817-50-3
    Catalog Number:
    10-4202
    Activity:
    Selective sigma-2 agonist
    Chemical Name:
    1’-[4-[1-(4-Fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4’-piperidine;
    Alternate Names:
    Lu 28-179
    Molecular Weight:
    454.59
    Molecular Formula:
    C30H31FN2O
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • PRE084 | Selective sigma-1 agonist
    CAS:
    138847-85-5
    Catalog Number:
    10-4203
    Activity:
    Selective sigma-1 agonist
    Chemical Name:
    2-(4-Morpholinethyl) 1-phenylcyclohexanecarboxylate hydrochloride
    Molecular Weight:
    353.89
    Molecular Formula:
    C19H27NO3 • HCl
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Water (up to 7 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
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Antagonists

  • BD1047 dihydrobromide | Selective sigma-1 antagonist
    CAS:
    138356-21-5
    Catalog Number:
    10-4210
    Activity:
    Selective sigma-1 antagonist
    Chemical Name:
    N-[2-(3,4Dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide
    Molecular Weight:
    437.04
    Molecular Formula:
    C13H20Cl2N2 • 2HBr
    Solubility:
    Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • BD1063 dihydrochloride | Selective sigma-1 antagonist
    CAS:
    206996-13-6
    Catalog Number:
    10-4211
    Activity:
    Selective sigma-1 antagonist
    Chemical Name:
    1-[2-(3,4-Dichlorophenyl)ethyl]-4-methylpiperazine dihydrochloride
    Molecular Weight:
    346.13
    Molecular Formula:
    C13H18Cl2N2 • 2HCl
    Solubility:
    Soluble in Water (up to at least 25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • NE-100 | Selective sigma-1 antagonist
    CAS:
    149409-57-4
    Catalog Number:
    10-4200
    Activity:
    Selective sigma-1 antagonist
    Chemical Name:
    4-Methoxy-3-(2-phenylethoxy)-N,N,dipropylbenzeneethanamine hydrochloride
    Molecular Weight:
    391.97
    Molecular Formula:
    C23H33NO2 • HCl
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to 10 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • S1RA | Selective sigma-1 antagonist
    CAS:
    1265917-14-3
    Catalog Number:
    10-4201
    Activity:
    Selective Sigma1 antagonist
    Chemical Name:
    4-{2-[5-Methyl-1-(napthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine hydrochloride
    Alternate Names:
    E-52862 HCl
    Molecular Weight:
    373.88
    Molecular Formula:
    C20H23N3O2 • HCl
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
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