April 21, 2025

Visit Focus Biomolecules at AACR

Focus Biomolecules will be exhibiting at the annual meeting of American Association for Cancer Research in Chicago, April 27 – 30. Stop by our booth (#1004) […]
March 20, 2025

eIF2B activator drug setback

FOCUS on drug failures. Denali Therapeutics‘ experimental drug for Amyotrophic Lateral Sclerosis (ALS) has taken another setback as the drug generated disappointing results in a phase […]
March 6, 2025

PI3Kalpha inhibitor in the news

Focus on Drug Discovery. Lilly will acquire Scorpion Therapeutics’ PI3Kalpha inhibitor program which includes STX-478, a potentially best-in-class mutant-selective PI3Kα inhibitor currently being evaluated in a […]
February 28, 2025

Neuroscience news

FOCUS on Reversal of Tau Pathology. In a January Communications Biology paper, Eric McGregor and coworkers showed that adiponectin receptor activation with the small molecule agonist, […]
February 26, 2025

Ginger component alleviates gut inflammation

FOCUS on Bioactive Natural Products. In a February Nature Communications paper, Wang and coworkers showed that a sesquiterpenoid found abundantly in ginger, known as furanodienone, alleviated […]
February 19, 2025

Tyrosine kinase drug approval

FOCUS on New Drug Approvals. Last Friday the FDA granted full approval of Deciphera’s Romvimza™ (Vimseltinib) for the treatment of symptomatic tenosynovial giant cell tumor (TGCT) […]
February 14, 2025

MEK inhbitor drug approval

FOCUS on New Drug Approvals. Yesterday the FDA approved SpringWorks Therapeutics‘ Mirdametinib (PD-325901) for the treatment of patients with neurofibromatosis type 1 with symptomatic plexiform neurofibromas […]
February 3, 2025

Parkinson’s drug failure

Focus on drug discovery failure. Development of Risvodetinib for Parkinson’s disease was halted following disappointing Phase II results. The drug, which is a potent, brain-penetrant c-Abl […]
February 3, 2025

New non-opioid pain drug

Focus on New Drug Approvals. The FDA approved Vertex Pharmaceutical’s Suzetrigine (VX-548) for the treatment of moderate to severe acute pain in adults. Suzetrigine is a […]