August 20, 2024
Drug Approval News: The FDA has approved JNJ’s Rybrevant® (Amivantamab-vmjw plus Lazertinib) as a first line chemotherapy-free treatment for patients with EGFR-mutated advanced lung cancer. Lazertinib […]
August 2, 2024
August 1st is World RNA Day and Focus Biomolecules is celebrating! Check out our broad portfolio of small molecule research tools for studying RNA. Don’t see […]
July 29, 2024
Journal Club: An excellent review of the TRPV1 channel was recently published in Cell Calcium, covering its structure, activation, and modulation, as well as its role […]
July 18, 2024
Focus on Natural Products: Celebrating the birthday of Satoshi Omura (July 12). Omura is well known for his work on the isolation and structure identification of […]
July 12, 2024
Natural Product Cellular Probes. Ascochlorin is a novel isoprenoid isolated from Acremonium egyptiacum. It is a specific inhibitor of the mitochondrial cytochrome bc1 complex (mitochondrial respiratory […]
July 9, 2024
Natural Product-Inspired Drugs. Camptothecin, an alkaloid isolated from Camptotheca acuminata, is a potent inhibitor of DNA topoisomerase I. Numerous useful analogs of camptothecin have been synthesized: […]
July 9, 2024
Focus on Natural Products: Microcystin LR, a cyanobacterial toxin that inhibits protein phosphatase 2A, was recently shown to stimulate tumor-associated macrophages to adopt an anti-tumor M1 […]
June 27, 2024
On World Microbiome Day (June 27, 2024) we focus on gut microbial metabolites. Phenylacetyl-L-glutamine (PAGln) was shown to be a cardiovascular disease-linked gut microbial metabolite acting […]
