Disease Model Inducers
In addition to exploring signaling pathways, small molecules are also used as a means to an end: to create a cell or animal model system for further research or drug screening. Focus Biomolecules offers small molecule tools to induce model systems such as: Streptozotocin (diabetes, Alzheimer’s); Kainic acid (neurodegeneration); Bleomycin sulfate (pulmonary fibrosis); and many others to create cancer or stem cell models.
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Bleomycin sulfate | Induces double strand DNA breaks
From $75.00CAS:9041-93-4Catalog Number:10-2623Activity:Fibrosis-inducing agentSource:From Streptomyces verticillusMolecular Weight:1512.62Molecular Formula:C55H85N17O25S4Solubility:Soluble in Water (up to 20 mg/ml)Physical Properties:White or off-white solidPurity:Contains a mixture of A2 (~70%) and B2 (~30%) forms
95% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from the date of purchase. Solutions in distilled water may be stored at -20°C for up to 3 months.Shipping Code:RT -
Conduritol B epoxide | Glycosidase inhibitor
From $45.00CAS:6090-95-5Catalog Number:10-1172Activity:β-Glycosidase inhibitorAlternate Names:CBEChemical Name:D,L-1,2-Anhydro-myo-inositolMolecular Weight:162.14Molecular Formula:C6H10O5Solubility:Soluble in Water (up to 25 mg/ml) or in DMSOPhysical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Compound is hygroscopic, protect from moisture. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.Shipping Code:RT -
Cyclothiazide | AMPA receptor positive allosteric modulator
From $50.00CAS:2259-96-3Catalog Number:10-2449Activity:AMPA receptor positiv e allosteric modulatorChemical Name:6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxideAlternate Names:LY-35483Molecular Weight:389.88Molecular Formula:C14H16ClN3O4S2Solubility:Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 9 mg/ml)Physical Properties:Off-white solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Ibotenic acid | NMDA and mGluR agonist
From $50.00CAS:2552-55-8Catalog Number:10-2693Activity:NMDA and mGluR agonistChemical Name:α-Amino-3-hydroxy-5-isoxazoleacetic acid hydrateMolecular Weight:176.13Molecular Formula:C5H6N2O4 • H2OSolubility:Soluble in Water (up to 1 mg/ml)Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.Shipping Code:RT
