Cytokine modulators
Cytokines are a diverse group of small proteins comprising interleukins, interferons, chemokines, lymphokines, and tumor necrosis factors (TNF). Not only are they key players in inflammation and immune response, but they also have roles in wound healing, cell cycling and death, and cancer progression. Their receptors are just as diverse, being immunoglobulins and transmembrane proteins that transmit signals via kinases and GPCRs.
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AZD-2098 | CCR4 antagonist
From $50.00CAS:566203-88-1Catalog Number:10-4262Activity:CCR4 antagonistChemical Names:2,3-Dichloro-N-(3-methoxypyrazine-2-yl)benzenesulfonamideMolecular Weight:334.17Molecular Formula:C11H9Cl2N3O3SSolubility:Soluble in DMSO (>25 mg/ml)Physical Properties:Off-white/beige solidPurity:>98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
CH-223191 | Arylhydrocarbon receptor antagonist
From $50.00CAS:301326-22-7Catalog Number:10-3089Activity:Arylhydrocarbon receptor antagonistChemical Name:1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]-1H-pyrazole-5-carboxamideMolecular Weight:333.39Molecular Formula:C19H19N5OSolubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml with warming)Physical Properties:Orange solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Eltrombopag | Small molecule thrombopoietin agonist
From $55.00CAS:496775-61-2Catalog Number:10-3768Activity:Small molecule thrombopoietin agonistChemical Name:3’-[2-[(2Z)-1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2’-hydroxy-[1,1’-biphenyl]-3-carboxylic acidAlternate Name:SB-497115Molecular Weight:442.47Molecular Formula:C25H22N4O4Solubility:Soluble in DMSO (up to 55 mg/ml) or in ethanol (up to 14 mg/ml).Physical Properties:Orange solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
GSK-J1 | JMJ H3K27 Demethylase inhibitor (Non-cell permeable)
From $75.00CAS:1373422-53-7Catalog Number:10-1393Activity:JMJ H3K27 Demethylase inhibitor (Non-cell permeable)Chemical Name:N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanineMolecular Weight:389.46Molecular Formula:C22H23N5O2Solubility:Soluble in DMSO (up to 20 mg/ml).Physical Properties:Pale yellow solidPurity:99% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.Shipping Code:RT -
GSK-J4 | JMJ H3K27 Demethylase inhibitor (Cell Permeable)
From $50.00CAS:1373423-53-0Catalog Number:10-1394Activity:JMJ H3K27 Demethylase inhibitor (Cell Permeable)Chemical Name:N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl esterMolecular Weight:417.48Molecular Formula:C24H27N5O2Solubility:Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml).Physical Properties:Yellow waxy solidPurity:99% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
GSK583 | RIP2 kinase inhibitor
From $40.00CAS:1346547-00-9Catalog Number:10-4761Activity:RIP2 kinase inhibitorChemical Name:6-tert-Butylsulfonyl-N-(5-fluoro-1H-indazol-3-yl)quinoline-4-amineMolecular Weight:398.45Molecular Formula:C20H19FN4O2SSolubility:Soluble in DMSO (up to at least 25 mg/ml).Physical Properties:Pale yellow solidPurity:98% by HPLCNMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT
