C19-9 | non-RGD integrin αvß3 receptor inhibitor
C19-9 (1477482-47-5) is a novel non-RGD inhibitor of the integrin αvß3 receptor (KD = 102 nM). It was active against the human prostate carcinoma epithelial cell
Extracellular matrix / Cell adhesion
Extracellular matrix (ECM), primarily comprising collagen, provides scaffolding for cells but also contains growth factors, proteins, enzymes, and other macromolecules essential for tissue and organ development and function. Adhesion molecules enable attachment to ECM and basement membranes (BM).
Cell adhesion
C-DIM 8 | Nur77 Antagonist
CAS:
151358-47-3
Catalog Number:
10-5157
Activity:
Nur77 antagonist
Chemical Names:
1,1-Bis(3’-indolyl)-1-(p-hydroxyphenyl)methane
Alternate Name:
DIM-C-pPhOH
Molecular Weight:
338.41
Molecular Formula:
C23H18N2O
Solubility:
Soluble in DMSO (35 mg/ml); ethanol (35 mg/ml)
Physical Properties:
Pink solid
Purity:
>98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
KNK437 | HSP70 inhibitor
CAS:
218924-25-5
Catalog Number:
10-5561
Activity:
HSP70 inhibitor
Chemical Names:
3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde
Molecular Weight:
245.23
Molecular Formula:
C13H11NO4
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
FAK
FAK inhibitor 14 | FAK inhibitor
CAS:
4506-66-5
Catalog Number:
10-2547
Activity:
FAK inhibitor
Alternate Names:
Y15
Chemical Name:
1,2,4,5-Benzenetetramine tetrahydrochloride
Molecular Weight:
284.02
Molecular Formula:
C6H10N4 4HCl
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Water (up to 15 mg/ml).
Physical Properties:
Grey solid
Purity:
98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT
Defactinib | Potent FAK inhibitor
CAS:
1073154-85-4
Catalog Number:
10-4828
Activity:
Potent FAK inhibitor
Chemical Name:
N-Methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]aminl]benzamide
Molecular Weight:
510.50
Molecular Formula:
C20H21F3N8O3S
Solubility:
Soluble in DMSO (up to at least 25mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
MMPs
Actinonin | Leucyl aminopeptidase inhibitor
CAS:
13434-13-4
Catalog Number:
10-2549
Activity:
Leucyl aminopeptidase inhibitor
Chemical Name:
3-[[1-[-2-Hydroxymethyl)-1-pyrrolidinyl)carbonyl]-2-methylpropyl]carbamoyl]-octanohydroxamic acid
Molecular Weight:
385.51
Molecular Formula:
C19H36N3O5
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT
Ilomastat (GM-6001) | MMP inhibitor
CAS:
142880-36-2
Catalog Number:
10-1339
Activity:
MMP inhibitor
Alternate Names:
GM-6001
Chemical Name:
N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide
Molecular Weight:
388.46
Molecular Formula:
C20H28N4O4
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
97% by TLC
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
NNGH | MMP inhibitor (pan specific)
CAS:
161314-17-6
Catalog Number:
10-1045
Activity:
MMP inhibitor (pan spec.)
Chemical Name:
N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid
Molecular Weight:
316.38
Molecular Formula:
C13H20N2O5S
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 8 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
ROCK
Y-27632 dihydrochloride | ROCK family kinase inhibitor
CAS:
129830-38-2
Catalog Number:
10-2301
Activity:
ROCK family kinase inhibitor
Chemical Name:
(R)-(+)-trans-4-(1-Aminoethyl)-N-(-4-pyridyl)cyclohexanecarboxamide dihydrochloride
Molecular Weight:
320.26
Molecular Formula:
C14H21N3O 2HCl
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Methanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or methanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
