Highly Selective Inhibitors
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Larotrectinib | TRK inhibitor
From $60.00CAS:1223403-58-4Catalog Number:10-4832Activity:Potent and selective panTRK inhibitorChemical Name:(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)pyrrolidine-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamideAlternate Name:LOXO-101; ARRY-470Molecular Weight:428.44Molecular Formula:C21H22F2N5O2Solubility:Soluble in DMSO (up to 5 mg/ml).Physical Properties:Yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.Shipping Code:RT -
Linsitinib | Inhibits IGF-1R kinase and InsR kinase
From $60.00CAS:867160-71-2Catalog Number:10-4814Activity:Inhibits IGF-1R kinase and InsR kinaseChemical Name:3-[8-Amino-1-(2-phenyl-7-quinolyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutanolAlternate Names:OSI-906Molecular Weight:421.49Molecular Formula:C26H23N5OSolubility:Soluble in DMSO (up to 30 mg/ml)Physical Properties:Yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.Shipping Code:RT -
MK-2206 | Potent and selective AKT inhibitor
From $60.00CAS:1032350-13-2Catalog Number:10-4801Activity:Potent and selective AKT inhibitorChemical Name:8-(4-(1-Aminocyclobutyl)phenyl-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one dihydrochlorideMolecular Weight:480.39Molecular Formula:C25H21N5O • 2HClSolubility:Soluble in DMSO (up to 10 mg/ml with warming)Physical Properties:Yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
ML167 | Clk4 inhibitor
From $75.00CAS:1285702-20-6Catalog Number:10-4543Activity:Clk4 inhibitorChemical Name:[5-[4-[(5-Methylfuran-2-yl)methylamino]quinazolin-6-yl]furan-2-yl]methanolMolecular Weight:335.36Molecular Formula:C19H17N2O3Solubility:Soluble in DMSO (greater than 25 mg/ml).Physical Properties:White solidPurity:>98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.Shipping Code:RT
