Highly Selective Inhibitors
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Ipatasertib | pan-Akt inhibitor
From $65.00CAS:1001264-89-6Catalog Number:10-4751Activity:pan-Akt inhibitorChemical Names:(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-yla,ino)propan-1-one; GDC-0068Molecular Weight:458.00Molecular Formula:C24H32ClN5O2Solubility:Soluble in DMSO (25 mg/mL) or ethanol (20 mg/mL)Physical Properties:Off-white to pale pink solidPurity:>98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Larotrectinib | TRK inhibitor
From $60.00CAS:1223403-58-4Catalog Number:10-4832Activity:Potent and selective panTRK inhibitorChemical Name:(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)pyrrolidine-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamideAlternate Name:LOXO-101; ARRY-470Molecular Weight:428.44Molecular Formula:C21H22F2N5O2Solubility:Soluble in DMSO (up to 5 mg/ml).Physical Properties:Yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.Shipping Code:RT -
Linsitinib | Inhibits IGF-1R kinase and InsR kinase
From $60.00CAS:867160-71-2Catalog Number:10-4814Activity:Inhibits IGF-1R kinase and InsR kinaseChemical Name:3-[8-Amino-1-(2-phenyl-7-quinolyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutanolAlternate Names:OSI-906Molecular Weight:421.49Molecular Formula:C26H23N5OSolubility:Soluble in DMSO (up to 30 mg/ml)Physical Properties:Yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.Shipping Code:RT
