STING

The presence of cytosolic DNA (which can result from viral or bacterial infection) is detected by cyclic GMP-AMP Synthase (cGAS). Their binding activates cGAS, generating the cyclic dinucleotide cGAMP; this in turn causes Stimulator of Interferon Genes (STING) to activate a signaling cascade resulting in interferon release and autophagy and lysosome-dependent cell death. The presence of endogenous DNA (e.g. from cellular stress) can also activate the pathway, leading to inflammation and autoimmune attack.

Home >> Biochemical Targets >> STING

Agonists

SR-717 | STING agonist

CAS:

2375421-09-1

Catalog Number:

10-4850

Activity:

STING agonist

Chemical Names:

Lithium 2-(6-(1H-Imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate

Molecular Weight:

381.27

Molecular Formula:

C₁₅H₈F₂N₅O₃·Li

Solubility:

Soluble in DMSO (>25 mg/ml)

Physical Properties:

Off-white solid

Purity:

>98% HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month1.

Shipping Code:

2′,3′-cGAMP | Endogenous STING agonist

CAS:

1441190-66-4

Catalog Number:

10-1639

Activity:

Endogenous STING agonist

Chemical Name:

Adenylyl-(3’5’)-2’guanylic acid, cyclic nucleotide, disodium salt

Alternate Name:

2′,3’cyclic GMP-AMP

Molecular Weight:

718.38

Molecular Formula:

C₂₀H₂₂N₁₀O₁₃P₂·2Na

Solubility:

Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to 10 mg/ml)

Physical Properties:

White solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.

Shipping Code:

DMXAA | STING agonist

CAS:

117570-53-3

Catalog Number:

10-2676

Activity:

STING agonist

Chemical Name:

5,6-Dimethylxanthenone-4-acetic acid

Alternate Names:

ASA404; Vadimezan

Molecular Weight:

282.29

Molecular Formula:

C₁₇H₁₄O₄

Solubility:

Soluble in DMSO (up to 5 mg/ml) or in DMF (up to 14 mg/ml with warming)

Physical Properties:

Off-white solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.

Shipping Code:

Antagonists

STING Degrader 2 | STING molecular glue

CAS:

N/A

Catalog Number:

10-3939

C-178 | STING Antagonist

CAS:

329198-87-0

Catalog Number:

10-4131

Activity:

STING Antagonist

Chemical Name:

N-3-Dibenzofuranyl-5-nitrofuran-2-carboxamide

Molecular Weight:

322.28

Molecular Formula:

C₁₇H₁₀N₂O₅

Solubility:

Soluble in DMSO (up to 25 mg/ml)

Physical Properties:

Orange solid

Purity:

98%
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

H-151 | STING Antagonist

CAS:

941987-60-6

Catalog Number:

10-4132

Activity:

STING Antagonist

Chemical Name:

N-(4-Ethylphenyl)-N’-1H-indol-3-yl urea

Molecular Weight:

279.34

Molecular Formula:

C₁₇H₁₇N₃O

Solubility:

Soluble in DMSO (up to 25 mg/ml)

Physical Properties:

Off-white solid

Purity:

98%
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

cGAS

RU.521 | cGAS Inhibitor

CAS:

2262452-06-0

Catalog Number:

10-4140

Activity:

cGAS Inhibitor

Chemical Name:

3-[1-(6,7-Dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methylpyrazol-4-yl]-3H-isobenzofuran-1-one

Molecular Weight:

415.23

Molecular Formula:

C₁₉H₁₂Cl₂N₄O₃

Solubility:

Soluble in DMSO (>25 mg/ml)

Physical Properties:

Off-white to pale pink solid

Purity:

>98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Shipping Code:

STING

Agonists

SR-717 | STING agonist

2′,3′-cGAMP | Endogenous STING agonist

DMXAA | STING agonist

Antagonists

STING Degrader 2 | STING molecular glue

C-178 | STING Antagonist

H-151 | STING Antagonist

cGAS

RU.521 | cGAS Inhibitor

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

STING

Agonists

SR-717 | STING agonist

2′,3′-cGAMP | Endogenous STING agonist

DMXAA | STING agonist

Antagonists

STING Degrader 2 | STING molecular glue

C-178 | STING Antagonist

H-151 | STING Antagonist

cGAS

RU.521 | cGAS Inhibitor

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules Plymouth Meeting, PA USA1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21