Cell Cycle

Cells proliferate by a process that consists of four coordinated processes that ultimately lead to cell division. 95% of this cell cycle is spent in what is called interphase during which the cell grows and prepares for DNA replication (G1 phase), DNA is synthesized (S phase), and finally protein synthesis in preparation for mitosis (G2 phase). The final phase of the cell cycle (mitosis or M phase) involves nuclear division .These stages are controlled by ‘checkpoints’ that prevent unwanted progression that might result in DNA or cellular damage. Mutations in key cell cycle components, such as p53 or ras, are hallmarks of cancer and allow the cell to proceed through stopped checkpoints.

Aurora kinase

  • AZD1152-HQPA | Aurora B kinase inhibitor
    CAS:
    722544-51-6
    Catalog Number:
    10-4804
    Activity:
    Aurora B kinase inhibitor
    Chemical Name:
    3-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino-N-(3-fluorophenyl)-1H-pyrazole-5-acetamide
    Alternate Name:
    Barasertib-HQPA; AZD2811
    Molecular Weight:
    507.56
    Molecular Formula:
    C26H30FN7O3
    Solubility:
    Soluble in DMSO (up to 15 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • SNS-314 mesylate | Aurora kinase inhibitor
    CAS:
    1146618-41-8
    Catalog Number:
    10-4779
    Activity:
    Aurora kinase inhibitor
    Chemical Name:
    1-(3-Chlorophenyl)-3-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl]urea mesylate
    Molecular Weight:
    527.04
    Molecular Formula:
    C18H15ClN6OS2 • CH3SO3H
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Alisertib | Potent and selective inhibitor of Aurora A / Destabilizes Myc
    CAS:
    1028486-01-2
    Catalog Number:
    10-4124
    Activity:
    Potent and selective inhibitor of Aurora A / Destabilizes Myc
    Chemical Name:
    4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid
    Alternate Names:
    MLN8237
    Molecular Weight:
    518.92
    Molecular Formula:
    C27H20ClFN4O4
    Solubility:
    Soluble in DMSO (up to 5 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Tozasertib | Aurora kinase inhibitor
    CAS:
    639089-54-6
    Catalog Number:
    10-2178
    Activity:
    Aurora kinase inhibitor
    Alternate Names:
    VX-680, MK-0457
    Molecular Weight:
    464.59
    Molecular Formula:
    C23H28N8OS
    Solubility:
    Soluble in DMSO (up to 100 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • ZM-447439 | Aurora B kinase inhibitor
    CAS:
    331771-20-1
    Catalog Number:
    10-1037
    Activity:
    Aurora B kinase inhibitor
    Chemical Name:
    N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
    Molecular Weight:
    513.59
    Molecular Formula:
    C29H31N5O4
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase  as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Aurora kinase Products

cdc25 phosphatase

  • NSC95397 | CtBP inhibitor; Cdc25 phosphatase inhibitor
    CAS:
    93718-83-3
    Catalog Number:
    10-1565
    Activity:
    CtBP inhibitor; Cdc25 phosphatase inhibitor
    Chemical Name:
    2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone
    Molecular Weight:
    310.39
    Molecular Formula:
    C14H14O4S2
    Solubility:
    Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 1 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • NSC663284 | Cdc25 phosphatase inhibitor
    CAS:
    383907-43-5
    Catalog Number:
    10-1352
    Activity:
    Cdc25 phosphatase inhibitor
    Chemical Name:
    6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione
    Molecular Weight:
    321.77
    Molecular Formula:
    C15H16ClN3O3
    Solubility:
    Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 55 mg/ml).
    Physical Properties:
    Red solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All cdc25 phosphatase Products

CHK

  • AZD7762 | Checkpoint kinase 1/2 inhibitor
    CAS:
    860352-01-8 (free base)
    Catalog Number:
    10-4771
    Activity:
    Checkpoint kinase 1/2 inhibitor
    Chemical Name:
    3-(Carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide hydrochloride
    Molecular Weight:
    398.88
    Molecular Formula:
    C17H19FN4O2S • HCl
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml).
    Physical Properties:
    Yellow or brown solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Quinacrine HCl | Antiprotozoan / Anticancer
    CAS:
    69-05-6
    Catalog Number:
    10-4251
    Activity:
    Antiprotozoan / Anticancer
    Chemical Name:
    6-Chloro-9-(4-diethylamino-1-methylbutyl)amino-2-methoxyacridine dihydrochloride
    Molecular Weight:
    472.88
    Molecular Formula:
    C23H30ClN3O • 2HCl
    Solubility:
    Soluble in Water (up to at least 25 mg/ml) or in DMSO (up to at least 10 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. Solutions in water should be made fresh daily.
    Shipping Code:
    RT
  • LY2603618 | Potent and selective Chk1 inhibitor
    CAS:
    911222-45-2
    Catalog Number:
    10-4123
    Activity:
    Potent and selective Chk1 inhibitor
    Chemical Name:
    N-[5-bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N’-(5-methyl-2-pyrazinyl)urea
    Alternate Names:
    Rabusertib
    Molecular Weight:
    436.30
    Molecular Formula:
    C18H22BrN5O3
    Solubility:
    Soluble in DMSO (up to 10 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • BML-277 | CHK2 inhibitor
    CAS:
    516480-79-8
    Catalog Number:
    10-1024
    Activity:
    CHK2 inhibitor
    Chemical Name:
    2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
    Molecular Weight:
    363.81
    Molecular Formula:
    C20H14ClN3O2
    Solubility:
    Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR conforms
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All CHK Products

Cyclin/CDK

  • SU9516 | pan-specific CDK inhibitor
    CAS:
    SU9516
    Catalog Number:
    10-5705
    Activity:
    pan-specific CDK inhibitor
    Chemical Names:
    (Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-2-one
    Molecular Weight:
    241.25
    Molecular Formula:
    C13H11N3O2
    Solubility:
    Soluble in DMSO (25 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • NG52 | Phosphoglycerate kinase 1 inhibitor
    CAS:
    212779-48-1
    Catalog Number:
    10-4681
    Activity:
    Phosphoglycerate kinase 1 inhibitor
    Chemical Names:
    2-[[6-(3-Chloroanilino)-9-propan-2-ylpurin-2-yl]amino]ethanol
    Molecular Weight:
    346.82
    Molecular Formula:
    C16H19ClN6O
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Kenpaullone | GSK-3ß/CDK/KLF4 inhibitor
    CAS:
    142273-20-9
    Catalog Number:
    10-3028
    Activity:
    GSK-3ß/CDK/KLF4 inhibitor
    Chemical Names:
    9-Bromo-7,12-dihydro-indolo[3,2-d]benzazepine-6(5H)-one; NSC 664704
    Molecular Weight:
    327.18
    Molecular Formula:
    C16H11BrN2O
    Solubility:
    Soluble in DMSO (35 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Abemaciclib | Potent and selective CDK 4/6 inhibitor
    CAS:
    1231930-82-7
    Catalog Number:
    10-4833
    Activity:
    Potent and selective CDK 4/6 inhibitor
    Chemical Name:
    N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyridine-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine methanesulfonic acid salt
    Alternate Name:
    LY2835219 mesylate
    Molecular Weight:
    602.70
    Molecular Formula:
    C27H32F2N8 ∙ CH3SO3H
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to at least 25 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • RO-3306 | Selective CDK1 inhibitor
    CAS:
    872573-93-8
    Catalog Number:
    10-4126
    Activity:
    Selective CDK1 inhibitor
    Chemical Name:
    5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone
    Molecular Weight:
    351.45
    Molecular Formula:
    C18H13N3OS2
    Solubility:
    Soluble in DMSO (up to 15 mg/ml)
    Physical Properties:
    Off-white or pale yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Cyclin/CDK Products

Inhibitors

  • SKPin C1 | Ubiquitin ligase E3 SCF-Skp2 inhibitor
    CAS:
    432001-69-9
    Catalog Number:
    10-1441
    Activity:
    Ubiquitin ligase E3 SCF-Skp2 inhibitor
    Chemical Names:
    2-[4-Bromo-2-[[4-oxo-3-(3-pyridinyl¬methyl)-2-thioxo-5-thiazolidinylidene]methyl]-phenoxy]acetic acid
    Molecular Weight:
    465.34
    Molecular Formula:
    C18H13BrN2O4S2
    Solubility:
    Soluble in DMSO (15 mg/ml with warming)
    Physical Properties:
    Yellow solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.
    Shipping Code:
    RT
  • Cytochalasin B | Actin filament disrupting agent
    CAS:
    14930-96-2
    Catalog Number:
    10-2069
    Activity:
    Actin filament disrupting agent
    Fermentation product:
    from Drechslera dematioidea
    Alternate Name:
    NSC107658; Phominone
    Molecular Weight:
    479.61
    Molecular Formula:
    C29H37NO5
    Solubility:
    Soluble in DMSO (up to 5 mg/ml); Ethanol (10 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Tomentosin | Inhibits NFkB activation
    CAS:
    33649-15-9
    Catalog Number:
    10-3538
    Activity:
    Inhibits NFkB activation
    Alternate Names:
    Xanthalongin
    Chemical Name:
    Sesquiterpenoid isolated from Inula viscosa
    Molecular Weight:
    248.32
    Molecular Formula:
    C15H20O3
    Solubility:
    Soluble in DMSO (50 mg/ml)
    Physical Properties:
    Yellow oil
    Purity:
    97% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.
    Shipping Code:
    RT
  • BO-264 | TACC3 inhibitor
    CAS:
    2408648-20-2
    Catalog Number:
    10-4685
    Activity:
    TACC3 inhibitor
    Chemical Names:
    3-(4-Methoxyphenyl)-N-(2-morpholin-4-ylpyrimidin-4-yl)-1,2-oxazol-5-amine
    Molecular Weight:
    353.38
    Molecular Formula:
    C18H19N5O3
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Lycorine HCl | Protein synthesis inhibitor/SCAP degrader
    CAS:
    2188-68-3
    Catalog Number:
    10-2608
    Activity:
    Protein synthesis inhibitor/SCAP degrader
    Chemical Names:
    Galanthidine; Amarylline; Narcissine
    Molecular Weight:
    323.77
    Molecular Formula:
    C16H17NO4·HCl
    Solubility:
    Soluble in water (15 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Inhibitors Products

Mitosis

  • XL413·HCl | Cdc7 inhibitor/CRISPR enhancer
    CAS:
    2062200-97-7
    Catalog Number:
    10-4414
  • Blebbistatin | Non-muscle myosin II inhibitor
    CAS:
    674289-55-5
    Catalog Number:
    10-2832
  • LDN-192960 2HCl | Haspin and DYRK2/3 inhibitor
    CAS:
    184582-62-5
    Catalog Number:
    10-4836
    Activity:
    Haspin and DYRJ2/3 inhibitor
    Chemical Names:
    3-(2,7-Dimethoxyacridin-9-yl)sulfanylpropan-1-amine dihydrochloride
    Molecular Weight:
    401.35
    Molecular Formula:
    C18H20N2O2S·2HCl
    Solubility:
    Soluble in DMSO (>25 mg/ml); Water (2 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • SIC5-6 | Separase inhibitor
    CAS:
    2410846-16-9
    Catalog Number:
    10-4075
    Activity:
    Separase inhibitor
    Chemical Name:
    3,3’-(1-((4-Iodophenyl)sulfonyl)piperidine-4,4’diyl)bis(1H-indole)
    Molecular Weight:
    581.47
    Molecular Formula:
    C27H24IN3O2S
    Solubility:
    Soluble in DMSO (up to at least 50 mg/ml).
    Physical Properties:
    White solid
    Purity:
    97% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • SGC-GAK-1 | Potent and selective Cyclin G Associated Kinase (GAK) inhibitor
    CAS:
    2226517-76-4
    Catalog Number:
    10-4796
    Activity:
    Potent and selective Cyclin G Associated Kinase (GAK) inhibitor
    Chemical Name:
    6-Bromo-N-(3,4,5-trimethoxyphenyl)quinoline-4-amine
    Molecular Weight:
    389.25
    Molecular Formula:
    C18H17BrN2O3
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 10 mg/ml)
    Physical Properties:
    Pale yellow solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
View All Mitosis Products

Synchronization

  • Taxol | Microtubule stabilizing agent
    CAS:
    33069-62-4
    Catalog Number:
    10-2095
    Activity:
    Microtubule stabilizing agent
    Alternate Names:
    Paclitaxel
    Molecular Weight:
    853.91
    Molecular Formula:
    C47H51NO14
    Solubility:
    Soluble in DMSO (up to 50 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Aphidicolin | DNA polymerase inhibitor
    CAS:
    38966-21-1
    Catalog Number:
    10-2058
    Activity:
    DNA polymerase inhibitor
    Chemical Name:
    (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol
    Molecular Weight:
    338.48
    Molecular Formula:
    C20H34O4
    Solubility:
    Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 1 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All Synchronization Products

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