Neurodegeneration

Neurodegeneration is a progressive deterioration of neuronal structures and function that ultimately leads to cognitive disability, dementia, and/or motor defects depending on the affected area of the brain. Neurodegenerative disorders can be caused by genetic mutations, aggregation of misfolded proteins, accumulation of toxic intracellular proteins, organelle membrane damage, and mitochondrial dysfunction. Common disorders include multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.

ALS

  • Repaglinide | Kir6 blocker
    CAS:
    135062-02-1
    Catalog Number:
    10-4661
  • Pridopidine | Sigma-1 ligand Neuroprotectant/Neurorestorative
    CAS:
    346688-38-8
    Catalog Number:
    10-4003
    Activity:
    Sigma-1 ligand Neuroprotectant Neurorestorative
    Chemical Name:
    4-(3-(Methylsulfonyl)phenyl)-1-propylpiperidine
    Alternate Name:
    ACR16
    Molecular Weight:
    281.41
    Molecular Formula:
    C15H23NO2S
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    >98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Riluzole | Sodium channel blocker / Neuroprotective
    CAS:
    1744-22-5
    Catalog Number:
    10-2815
    Activity:
    Sodium channel blocker / Neuroprotective
    Chemical Name:
    2-Amino-6-(trifluoromethoxy)benzothiazole
    Molecular Weight:
    234.20
    Molecular Formula:
    C8H5F3N2OS
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • WHI-P131 | JAK3 inhibitor
    CAS:
    202475-60-3
    Catalog Number:
    10-1190
    Activity:
    JAK3 inhibitor
    Alternate Names:
    JANEX-1
    Chemical Name:
    4-[(4′-Hydroxyphenyl)amino]-6,7-dimethoxyquinazoline
    Molecular Weight:
    333.78
    Molecular Formula:
    C16H15N3O3·HCl
    Solubility:
    Soluble in DMSO (up to 50 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • P7C3 | Neuroprotective agent
    CAS:
    301353-96-8
    Catalog Number:
    10-1150
    Activity:
    Neuroprotective agent
    Chemical Name:
    1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol
    Molecular Weight:
    474.2
    Molecular Formula:
    C21H18Br2N2O
    Solubility:
    Soluble in DMSO (up to 30 mg/ml).
    Physical Properties:
    Off-white
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
    Shipping Code:
    RT
View All ALS Products

Alzheimers

View All Alzheimers Products

Huntingtons

  • Repaglinide | Kir6 blocker
    CAS:
    135062-02-1
    Catalog Number:
    10-4661
  • Laquinimod | Immunomodulator
    CAS:
    248281-84-7
    Catalog Number:
    10-4971
    Activity:
    Immunomodulator
    Chemical Names:
    5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenylquinoline-3-carboxamide
    Alternate Name:
    ABR-215062
    Molecular Weight:
    356.81
    Molecular Formula:
    C19H17ClN2O3
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • QNZ | NFkB inhibitor / Store operated calcium entry
    CAS:
    545380-34-5
    Catalog Number:
    10-4009
    Activity:
    NF-kB inhibitor / Store-operated calcium entry
    Chemical Name:
    4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine
    Alternate Name:
    EVP4593
    Molecular Weight:
    356.42
    Molecular Formula:
    C22H20N4O
    Solubility:
    Soluble in DMSO (up to 20 mg/ml).
    Physical Properties:
    Pale yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Pridopidine | Sigma-1 ligand Neuroprotectant/Neurorestorative
    CAS:
    346688-38-8
    Catalog Number:
    10-4003
    Activity:
    Sigma-1 ligand Neuroprotectant Neurorestorative
    Chemical Name:
    4-(3-(Methylsulfonyl)phenyl)-1-propylpiperidine
    Alternate Name:
    ACR16
    Molecular Weight:
    281.41
    Molecular Formula:
    C15H23NO2S
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    >98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Gabapentin lactam | Neuroprotective agent
    CAS:
    64744-50-9
    Catalog Number:
    10-2535
    Activity:
    Neuroprotective agent
    Chemical Name:
    4,4-Pentamethylene-2-pyrrolidone
    Alternate Names:
    GBP-L
    Molecular Weight:
    153.22
    Molecular Formula:
    C09H15NO
    Solubility:
    Soluble in DMSO (up to 40 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All Huntingtons Products

Multiple sclerosis

  • Clemastine fumarate | Histamine H1 receptor antagonist/Enhances Remyelination
    CAS:
    14976-57-9
    Catalog Number:
    10-4644
  • Laquinimod | Immunomodulator
    CAS:
    248281-84-7
    Catalog Number:
    10-4971
    Activity:
    Immunomodulator
    Chemical Names:
    5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenylquinoline-3-carboxamide
    Alternate Name:
    ABR-215062
    Molecular Weight:
    356.81
    Molecular Formula:
    C19H17ClN2O3
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • AX-024 | Inhibitor of T cell antigen receptor (TCR)-dependent T cell activation
    CAS:
    1704801-24-0
    Catalog Number:
    10-4895
    Activity:
    Inhibitor of T cell antigen receptor (TCR)-dependent T cell activation
    Chemical Name:
    1-[[4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl]methyl]pyrrolidine hydrochloride
    Molecular Weight:
    375.86
    Molecular Formula:
    C21H22FNO2•HCl
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml with warming) or in Water (10 mg/ml with warming).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • N6022 | S-Nitrosoglutathione reductase inhibitor
    CAS:
    1208315-24-5
    Catalog Number:
    10-4103
    Activity:
    S-Nitrosoglutathione reductase inhibitor
    Chemical Name:
    3-(5-(4-(1H-Imidazol-1-yl)phenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid
    Molecular Weight:
    414.46
    Molecular Formula:
    C24H22N4O3
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20° C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • BI-D1870 | p90 ribosomal S6 kinase inhibitor
    CAS:
    501437-28-1
    Catalog Number:
    10-4791
    Activity:
    p90 ribosomal S6 kinase inhibitor
    Chemical Name:
    2-(3,5-Difluoro-4-hydroxyanilino)-5,7-dimethyl-8-(3-methylbutyl)-7H-pteridin-6-one
    Molecular Weight:
    391.42
    Molecular Formula:
    C19H23F2N5O2
    Solubility:
    Soluble in DMSO (up to 15 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Multiple sclerosis Products

Neuronal stem cells

  • Guggulsterone-(Z) | FXR antagonist
    CAS:
    39025-23-5
    Catalog Number:
    10-3816
    Activity:
    FXR antagonist
    Chemical Name:
    (Z)-Pregna-4,17(20)-diene-3,16-dione
    Molecular Weight:
    312.45
    Molecular Formula:
    C21H28O2
    Solubility:
    Soluble in DMSO (up to 6 mg/ml with warming) or in Ethanol (up to 3 mg/ml with warming).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Neurodazine | Induces stem cell neuronal differentiation
    CAS:
    937807-66-4
    Catalog Number:
    10-4515
    Activity:
    Induces stem cell neuronal differentiation
    Chemical Name:
    2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole
    Molecular Weight:
    456.92
    Molecular Formula:
    C27H21ClN2O3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    Beige solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • TOFA | Acyl-CoA carboxylase inhibitor
    CAS:
    54857-86-2
    Catalog Number:
    10-1464
    Activity:
    Acyl-CoA carboxylase inhibitor
    Alternate Names:
    RMI-14514
    Chemical Name:
    5-(Tetradecyloxy)-2-furoic acid
    Molecular Weight:
    324.47
    Molecular Formula:
    C19H32O4
    Solubility:
    Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 9 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • ISX9 | Neurogenic differentiation inducer
    CAS:
    832115-62-5
    Catalog Number:
    10-1357
    Activity:
    Neurogenic differentiation inducer
    Chemical Name:
    N-Cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide
    Molecular Weight:
    234.28
    Molecular Formula:
    C11H10N2O2S
    Solubility:
    Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 16 mg/ml).
    Physical Properties:
    Tan solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Neuropathiazol | Induces neuronal differentiation
    CAS:
    880090-88-0
    Catalog Number:
    10-1291
    Activity:
    Induces neuronal differentiation
    Chemical Name:
    Ethyl 4-(methyl(2-phenylthiazol-4-yl)amino)benzoate
    Molecular Weight:
    338.43
    Molecular Formula:
    C19H18N2O2S
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    Off white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Neuronal stem cells Products

Other Neurodegeneration

  • CBA | TRPM4 blocker
    CAS:
    351424-20-9
    Catalog Number:
    10-3643
  • Linopirdine dihydrochloride | Kv7 Blocker
    CAS:
    113168-57-3
    Catalog Number:
    10-4654
  • GSK2606414 | PERK inhibitor
    CAS:
    1337531-36-8
    Catalog Number:
    10-4716
  • TTK21 | CBP/p300 histone acetyltransferase activator
    CAS:
    709676-56-2
    Catalog Number:
    10-5669
    Activity:
    Histone acetyltransferase CBP/p300 activator
    Chemical Names:
    N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide
    Molecular Weight:
    357.76
    Molecular Formula:
    C17H15ClF3NO2
    Solubility:
    Soluble in DMSO (50 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Dyclonine HCl | Mitochondrial function enhancer
    CAS:
    536-43-6
    Catalog Number:
    10-3895
    Activity:
    Mitochondrial function enhancer
    Chemical Names:
    4′-Butoxy-3-piperidinopropiophenone, hydrochloride
    Molecular Weight:
    325.87
    Molecular Formula:
    C18H27NO2·HCl
    Solubility:
    Soluble in DMSO (20 mg/ml); Water (25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    Room temperature
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All Other Neurodegeneration Products

Parkinsons

  • RECTAS | pre-mRNA splicing modulator
    CAS:
    101862-47-9
    Catalog Number:
    10-5273
  • Repaglinide | Kir6 blocker
    CAS:
    135062-02-1
    Catalog Number:
    10-4661
  • Rotenone | Mitochondrial Complex I Inhibitor
    CAS:
    83-79-4
    Catalog Number:
    10-2277
    Activity:
    Mitochondrial Complex I Inhibitor
    Chemical Names:
    (2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one
    Alternate Name:
    NSC-26285; Nicouline
    Molecular Weight:
    394.42
    Molecular Formula:
    C23H22O6
    Solubility:
    Soluble in DMSO (50 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    Room Temperature
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • LMK235 | Selective HDAC4/5 inhibitor
    CAS:
    1418033-25-6
    Catalog Number:
    10-4024
    Activity:
    HDAC4/5 inhibitor
    Chemical Names:
    N-[6-(Hydroxyamino)-6-oxohexoxy]-3,5-dimethylbenzamide
    Molecular Weight:
    294.35
    Molecular Formula:
    C15H22N2O4
    Solubility:
    Soluble in DMSO (25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • AR7 | Activates chaperone mediated autophagy
    CAS:
    80306-38-3
    Catalog Number:
    10-5515
    Activity:
    Activates chaperone mediated autophagy
    Chemical Names:
    7-Chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine
    Molecular Weight:
    257.72
    Molecular Formula:
    C15H12ClNO
    Solubility:
    Soluble in DMSO (30 mg/ml)
    Physical Properties:
    Pale pink solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Parkinsons Products

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