Cellular Metabolism
AUTOPHAGY
Ion & Other Channels
Epigenetics
Cytoskeleton
Kinases
Mitochondria
Nuclear Receptors
Bioactive Lipids
Ubiquitin Proteasome
VIEW ALL Biochemical Targets
The ubiquitin-proteasome system (UPS) is a major intracellular protein degradation system in eukaryotes. Damaged, misfolded, or superfluous proteins are labeled with multiple ubiquitin molecules (a 76 amino acid peptide) via the sequential action of E1 activating enzyme, E2 conjugating enzyme, and E3 ligase ultimately leading to destruction of the protein by the 26S proteasome. Deubiquitinases cleave the bond between ubiquitin and protein. Dysregulation of the UPS and/or DUBs is implicated in many neurological disorders, cancer, atherosclerosis and other pathological states.
DUBs
P22077
P22077 is a selective USP7 inhibitor
WP1130
Inhibits USP5, 9x, 14, and UCH37
LDN-57444
LDN-57444 inhibits the ubiquitin C-terminal hydrolase (UCH-L1).
Proteasome
Epoxomicin
Potent, selective, and irreversible inhibitor of the 20S proteasome
Carfilzomib
Carfilzomib is a potent and irreversible proteasome inhibitor
MG-132
MG-132 is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome
E3 Ubiquitin Ligase
Heclin
Heclin is an inhibitor of the HECT domain-containing E3 ubiquitin ligases
Pomalidomide
A thalidomide analog that inhibits the E3 ubiquitin ligase cereblon.
NEW PRODUCTS
BIOCHEMICAL TARGETS
PROCESSES AND DISEASES
CUSTOM SYNTHESIS
CHEMICAL LIBRARIES
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
United Kingdom
Tebu-bio UK & Ireland
Unit 7 - Flag Business Exchange
Vicarage Farm Road
Peterborough
Cambs PE1 5TX
England
Phone: +44 (0)1733 421880
Fax: +44 (0)1733 421882
www.tebu-bio.com
2B Scientific
Cherwell Innovation Centre
77 Heyford Park
Upper Heyford
OX25 5HD
UK
Phone: +44(0) 1869 238033
Fax: +44(0) 1869 238034
E-mail: info@2BScientific.com
sales@2BScientific.com
www.2BScientific.com
Germany
Tebu-bio GmbH
Berliner Str. 255
D-63067 Offenbach
Tel: (069) 801013-0
Fax: (069) 801013-20
www.tebu-bio.com
BIOZOL Diagnostica Vertrieb GmbH
Obere Hauptstrasse 10b
85386 Eching
Tel: +498937996666
E-mail: info@biozol.de
www.biozol.de
Biotrend Germany
Wilhelm-Mauser-Str. 41-43
50827 Köln
Tel: +49 221 9498320
Fax: +49 221 9498325
Email:Â info @biotrend.com
www.biotrend.com
Portugal
Tebu-bio Portugal
Quinta da Fonte
Rua dos Malhões
EdifÃcio D. Pedro I
2770-071 Paco D'Arcos
Phone: 21 000 82 48
Fax: 21 000 16 75
www.tebu-bio.com
Fax: (069) 801013-20
www.tebu-bio.com
Switzerland
LucernaChem Ag
Abendweg 18
CH-6006 Luzern
Switzerland
Phone: +41 (0)41 420 9636
Fax: +41 (0)41 420 9656
E-mail: lucerna-chem@lucerna-chem.ch
www.lucerna-chem.ch
Anawa
Unterdorfstrasse 21
CH-8602 Wangen
Switzerland
Phone: +41 (0)44 805 76 81
Fax: +41 (0)44 805 76 75
E-mail: contactus@anawa.ch
www.anawa.ch
Belgium
Tebu-bio
tebu-bio Belgium
Alexander Franckstraat 196
B-2530 Boechout
Phone: 03/ 454 00 66
Fax: 03/ 454 18 88
www.tebu-bio.com
Austria
Biomedica Medizinprodukte gmbH & Co KG
Divischgasse 4
1210 Vienna
Austria
Phone: +43 1 291 07 0
Fax: +43 1 290 14 29
Email: office@bmgrp.at
www.bmgrp.at
Biotrend Austria
Sternwartwatrasse 76
A-1180 Wien
Austria
Phone: +43 7201 15577
Fax: +43 7201 15580
Email:info@biotrend.com
www.biotrend.com
Bulgaria
Biomedica Bulgaria Ltd.
2E "Akad. Ivan E. Geshov" blvd.
Business center "Serdika" build. 2, floor 2, office 203
Sofia 1330
Bulgaria
Phone: +359 2 447 2833
Fax: +359 2 447 2831
Email: office@bmgrp.bg
www.bmgrp.bg
Czech Republic
Biomedica CS, s.r.o.
Sokolovska 100/94, Meteor B
186 00 Praha 8 - Karlin
Czech Republic
Phone: +420 2 839 33 605
Fax: +420 2 839 32 507
Email: office@bmgrp.cz
www.bmgrp.cz
Macedonia
Biomedica dijagnostika Ltd.
Ul. Ilindenska br. 103 lokal 2 and 3
1000 Skopje
Macedonia
Phone: +389 232 22 404
Fax: +389 232 22 404
Email: office@bmgrp.mk
www.bmgrp.mk
Romania
Biomedica Medizinprodukte Romania SRL
Strada Siriului nr. 42-46, Et.2, Sector 1
014354 Bucharest
Romania
Phone: +40 37 276 68 44
Fax: +40 21 232 22 04
Email: office@bmgrp.ro
www.bmgrp.ro
France
Tebu-bio France
39 Rue de Houdan - BP 15
78612 Le Perray-en-Yvelines Cedex
Phone: 01 30 46 39 00
Fax: 01 30 46 39 11
www.tebu-bio.com
CliniSciences France
74 Rue des Suisses
92000 Nanterre
Phone: +33 9 77 40 09 09
Fax: +33 9 77 40 10 11
info@clinisciences.com
www.clinisciences.com
Spain
Tebu-bio Spain
Gran Via de les Corts Catalanes, 583-5°
ES-08011 Barcelona
Phone: 93 306 34 10
Fax: 93 306 34 99
www.tebu-bio.com
Italy
DBA Italia
Via Umbria, 10
20090 Segrate (Milan)
Italy
Phone: +39 02 26922300
Fax: +39 02 26923535
E-mail: info@dbaitalia.it
www.dbaitalia.it
Tebu-bio Italy
Via Pretorio 4 - C.P. 70
I-20013 Magenta MI
Phone: 02 97 20 50 10
Fax: 02 97 29 50 77
Clinisciences Italy
Via Maremmana Inferiore 378
00012 Guidonia Montecelio (Roma)
Phone: +39 06 94 80 56 71
Fax: +39 06 94 80 00 21
Italia@clinisciences.com
www.clinisciences.com
Denmark
CAT Science Park
Universitetsparken 7
4000 Roskilde
Denmark
Phone: +45 46 74 02 54
Fax: +45 46 74 02 53
www.tebu-bio.com
CliniSciences Denmark
Herlev Hovedgade 195
2730 Herlev
Phone: +45 89 888 349
Fax: +45 89 884 064
danmark@clinisciences.com
www.clinisciences.com
Sweden
Tebu-bio Netherlands Â
Bevelandseweg 80
NL-1703 AX Heerhugowaard
Phone: 072-572 21 00
Fax: 072-572 21 33
www.tebu-bio.com
Finland
Tebu-bio Netherlands Â
Bevelandseweg 80
NL-1703 AX Heerhugowaard
Phone: 072-572 21 00
Fax: 072-572 21 33
www.tebu-bio.com
Netherlands
Tebu-bio Netherlands Â
Bevelandseweg 80
NL-1703 AX Heerhugowaard
Phone: 072-572 21 00
Fax: 072-572 21 33
www.tebu-bio.com
Bosnia-Herzegovina
Biomedica d.o.o
Dr. Silve Rizvanbegovic bb
71210 Ilidza, Sarajevo
Bosnia and Herzegovina
Phone: +387 33 262 725
Fax: 387 33 262 726
Email: office@bmgrp.ba
www.bmgrp.ba
Croatia
Biomedica Dijagnostika d.o.o.
Strojarska 20/X
10000 Zagreb
Croatia
Phone: +385 1 888 5727
Fax: +385 1 888 5728
Email: office@bmgrp.hr
www.bmgrp.hr
Hungary
Biomedica Hungaria Kft.
Ganz u. 16
1027 Budapest
Hungary
Phone: +361 225 38 50
Fax: +361 201 26 84
Email: office@bmgrp.hu
www.bmgrp.hu
Poland
Biomedica Poland sp. z.o.o.
Ul. Raszynska 13
05-500 Piaseczno
Poland
Phone: +48 22 737 5996
Fax: +48 22 737 5994
Email: office@bmgrp.pl
www.bmgrp.pl
Serbia
Biomedica MP d.o.o. Â
Lazara Mamuzica 26a
11186 Zemun
Serbia
Phone: +381 11 630 1882
Fax: +381 11 630 1883
Email: office@bmgrp.rs
www.bmgrp.rs
Slovenia
Biomedica M.B. d.o.o. Â
Slokanova 12
2000 Maribor
Slovenia
Phone: +386 2 471 63 01
Fax: +386 2 471 63 04
Email: office@bmgrp.si
www.bmgrp.si
Slovakia
Biomedica Slovakia s.r.o.
Drobneho 27
84101 Bratislava
Slovakia
Phone: +421 2 693 099 01
Fax: +421 2 693 099 08
Email: office@bmgrp.sk
www.bmgrp.sk
®Copyright 2021 Focus Biomolecules. All Rights Reserved. Site by A.N. Creative