Cellular Metabolism
AUTOPHAGY
Ion & Other Channels
Epigenetics
Cytoskeleton
Kinases
Mitochondria
Nuclear Receptors
Bioactive Lipids
Ubiquitin Proteasome
VIEW ALL Biochemical Targets
The ubiquitin-proteasome system (UPS) is a major intracellular protein degradation system in eukaryotes. Damaged, misfolded, or superfluous proteins are labeled with multiple ubiquitin molecules (a 76 amino acid peptide) via the sequential action of E1 activating enzyme, E2 conjugating enzyme, and E3 ligase ultimately leading to destruction of the protein by the 26S proteasome. Deubiquitinases cleave the bond between ubiquitin and protein. Dysregulation of the UPS and/or DUBs is implicated in many neurological disorders, cancer, atherosclerosis and other pathological states.
DUBs
P22077
P22077 is a selective USP7 inhibitor
WP1130
Inhibits USP5, 9x, 14, and UCH37
LDN-57444
LDN-57444 inhibits the ubiquitin C-terminal hydrolase (UCH-L1).
Proteasome
Epoxomicin
Potent, selective, and irreversible inhibitor of the 20S proteasome
Carfilzomib
Carfilzomib is a potent and irreversible proteasome inhibitor
MG-132
MG-132 is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome
E3 Ubiquitin Ligase
Heclin
Heclin is an inhibitor of the HECT domain-containing E3 ubiquitin ligases
Pomalidomide
A thalidomide analog that inhibits the E3 ubiquitin ligase cereblon.
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