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Ubiquitin Proteasome

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The ubiquitin-proteasome system (UPS) is a major intracellular protein degradation system in eukaryotes. Damaged, misfolded, or superfluous proteins are labeled with multiple ubiquitin molecules (a 76 amino acid peptide) via the sequential action of E1 activating enzyme, E2 conjugating enzyme, and E3 ligase ultimately leading to destruction of the protein by the 26S proteasome. Deubiquitinases cleave the bond between ubiquitin and protein. Dysregulation of the UPS and/or DUBs is implicated in many neurological disorders, cancer, atherosclerosis and other pathological states.

Home >> Ubiquitin/Proteasome

DUBs

P22077

P22077 is a selective USP7 inhibitor

WP1130

Inhibits USP5, 9x, 14, and UCH37

LDN-57444

LDN-57444 inhibits the ubiquitin C-terminal hydrolase (UCH-L1).

Proteasome

Epoxomicin

Potent, selective, and irreversible inhibitor of the 20S proteasome

Carfilzomib

Carfilzomib is a potent and irreversible proteasome inhibitor

MG-132

MG-132 is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome

E3 Ubiquitin Ligase

Heclin

Heclin is an inhibitor of the HECT domain-containing E3 ubiquitin ligases

Pomalidomide

A thalidomide analog that inhibits the E3 ubiquitin ligase cereblon.

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