Cellular Metabolism

AUTOPHAGY

Ion & Other Channels

Epigenetics

Cytoskeleton

Kinases

Mitochondria

Nuclear Receptors

Bioactive Lipids

Ubiquitin Proteasome

VIEW ALL Biochemical Targets

The ubiquitin-proteasome system (UPS) is a major intracellular protein degradation system in eukaryotes. Damaged, misfolded, or superfluous proteins are labeled with multiple ubiquitin molecules (a 76 amino acid peptide) via the sequential action of E1 activating enzyme, E2 conjugating enzyme, and E3 ligase ultimately leading to destruction of the protein by the 26S proteasome. Deubiquitinases cleave the bond between ubiquitin and protein. Dysregulation of the UPS and/or DUBs is implicated in many neurological disorders, cancer, atherosclerosis and other pathological states.

DUBs

P22077

P22077 is a selective USP7 inhibitor

WP1130

Inhibits USP5, 9x, 14, and UCH37

LDN-57444

LDN-57444 inhibits the ubiquitin C-terminal hydrolase (UCH-L1).

Proteasome

Epoxomicin

Potent, selective, and irreversible inhibitor of the 20S proteasome

Carfilzomib

Carfilzomib is a potent and irreversible proteasome inhibitor

MG-132

MG-132 is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome

E3 Ubiquitin Ligase

Heclin

Heclin is an inhibitor of the HECT domain-containing E3 ubiquitin ligases

Pomalidomide

A thalidomide analog that inhibits the E3 ubiquitin ligase cereblon.

Ubiquitin/Proteasome

New Products

BIOCHEMICAL TARGETS

Processes and Diseases

CUSTOM SYNTHESIS

CHEMICAL LIBRARIES

FOCUS NEWS:

Update on the Latest Anti-SARS-CoV-2 Molecules

The emergence of SARS-CoV-2 has precipitated an unprecedented effort by the scientific community to find and develop potential therapeutics and vaccines for this new virus to halt the ongoing pandemic’s onslaught. Fortunately, the SARS-CoV-2 genome is highly...

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

®Copyright 2020 Focus Biomolecules. All Rights Reserved. Site by A.N. Creative