Mitochondria

Mitochondria are organelles found in every cell and provide most of the energy for cellular functioning and survival. They also help regulate cellular metabolism, are involved in apoptosis, calcium signaling, cell cycle control, and cell growth and differentiation. Mitochondrial dysfunction has been implicated in metabolic disorders, neurodegenerative diseases, ischemia-related heart and brain injury, cancer, cardiovascular disease, and other disorders.

Glutathione

  • 2-AAPA | Glutathione/thioredoxin reductase inhibitor
    CAS:
    1133387-90-2
    Catalog Number:
    10-3238
    Activity:
    Glutathione/thioredoxin reductase inhibitor
    Chemical Names:
    R,R′-2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)-phenylthiocarbamoylsulfanyl]propionic acid, hydrate
    Molecular Weight:
    518.65
    Molecular Formula:
    C18H22N4O6S4
    Solubility:
    Soluble in DMSO (50 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    95% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month1.
    Shipping Code:
    RT
  • Dehydrozingerone | Glutathione sponge
    CAS:
    1080-12-2
    Catalog Number:
    10-2526
    Activity:
    Glutathione sponge
    Chemical Name:
    (E)-4-(4-Hydroxy-3-methoxyphenyl)but-3-ene-2-one
    Molecular Weight:
    192.21
    Molecular Formula:
    C11H12O3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
    Physical Properties:
    Pale yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Carnosic acid | Antioxidant
    CAS:
    3650-09-7
    Catalog Number:
    10-2401
    Activity:
    antioxidant
    Chemical Name:
    Natural diterpenoid resorcinol isolated from Rosmarinus officinalis.
    Molecular Weight:
    332.42
    Molecular Formula:
    C20H28O4
    Solubility:
    Soluble in DMSO (up to 50 mg/ml).
    Physical Properties:
    Off-white or yellow solid
    Purity:
    95% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Piperlongumine | Glutathione sponge / Increases ROS levels
    CAS:
    20069-09-4
    Catalog Number:
    10-2377
    Activity:
    Glutathione sponge / Increases ROS levels
    Chemical Name:
    (E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one
    Molecular Weight:
    317.34
    Molecular Formula:
    C17H19NO5
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    Cream-colored solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • CAPE | Inhibits NFkB activation
    CAS:
    104594-70-9
    Catalog Number:
    10-2265
    Activity:
    Inhibits NFκB activation
    Alternate Names:
    Caffeic acid phenethylester
    Chemical Name:
    3-(3,4-Dihydroxyphenyl)-2-propenoic acid 2-phenylethyl ester
    Molecular Weight:
    284.32
    Molecular Formula:
    C17H16O4
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All Glutathione Products

Krebs Cycle

View All Krebs Cycle Products

Membrane Permeability

  • Tropodithietic acid | Cytotoxic disulfide antibiotic
    CAS:
    750590-18-2
    Catalog Number:
    10-3307
    Activity:
    Cytotoxic disulfide antibiotic
    Chemical Name:
    Oxo-8,9-dithiabicyclo[5.2.0]non-1,4,6-triene-2-carboxylic acid
    Molecular Weight:
    212.25
    Molecular Formula:
    C8H4O3S2
    Solubility:
    Soluble in DMSO (up to 5 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Cereulide | Mitochondrial toxin
    CAS:
    157232-64-9
    Catalog Number:
    10-2746
    Activity:
    Mitochondrial toxin
    Source:
    Isolated from Bacillus cereus
    Molecular Weight:
    1153.40
    Molecular Formula:
    C57H96N6O18
    Solubility:
    Soluble in DMSO or Ethanol
    Supplier As:
    Supplied in Methanol at a concentration of 25μg/500μl
    Purity:
    98% by HPLC
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Diluted solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Beauvericin | Disrupts mitochondrial volume
    CAS:
    26048-05-5
    Catalog Number:
    10-2061
    Activity:
    Disrupts mitochondrial volume
    Chemical Names:
    Cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl]
    Molecular Weight:
    783.95
    Molecular Formula:
    C45H57N3O9
    Solubility:
    Soluble in DMSO (30 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Decylubiquinone | MPTP inhibitor
    CAS:
    55486-00-5
    Catalog Number:
    10-2580
    Activity:
    MPTP inhibitor
    Chemical Name:
    2,3-Dimethoxy-5-methyl-6-decyl-1,4-benzoquinone
    Molecular Weight:
    322.44
    Molecular Formula:
    C19H30O4
    Solubility:
    Soluble in DMSO (up to 10 mg/ml)
    Physical Properties:
    Yellow or orange oil
    Purity:
    97% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Alamethicin | Pore-forming antimicrobial peptide
    CAS:
    27061-78-5
    Catalog Number:
    10-2055
    Activity:
    Pore-forming antimicrobial peptide
    Alternate Names:
    U-22324
    Molecular Weight:
    1964.31
    Molecular Formula:
    C92H150N22O25
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Methanol (up to 10 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC (mixture of alamethicin homologs)
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Membrane Permeability Products

Mitochondrial Transporters

  • MitoBloCK-10 | TIMM44 blocker
    CAS:
    394694-98-5
    Catalog Number:
    10-5324
  • Oligomycin A | Mitochondrial ATPase inhibitor
    CAS:
    579-13-5
    Catalog Number:
    10-5368
    Activity:
    Mitochondrial ATPase inhibitor
    Source:
    Streptomyces sp.
    Molecular Weight:
    791.06
    Molecular Formula:
    C45H74O11
    Solubility:
    Soluble in DMSO (up to 300 mg/ml); Ethanol (up to 200 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • MitoBloCK-12 | Mitochondrial import inhibitor
    CAS:
    522-51-0
    Catalog Number:
    10-1525
    Activity:
    Mitochondrial import inhibitor
    Chemical Name:
    1,1’-Decamethylenebis(4-aminoquinaldinium)dichloride
    Alternate Name:
    Dequalinium chloride; MB12; DECA
    Molecular Weight:
    527.58
    Molecular Formula:
    C30H40Cl2N4
    Solubility:
    Soluble in DMSO (up to 1 mg/ml with warming) or in Water (up to 1 mg/ml)
    Physical Properties:
    Beige solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • UK-5099 | Mitochondrial pyruvate transporter inhibitor
    CAS:
    56396-35-1
    Catalog Number:
    10-4748
    Activity:
    Mitochondrial pyruvate transporter inhibitor
    Chemical Name:
    2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid
    Molecular Weight:
    288.30
    Molecular Formula:
    C18H12N2O2
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 8 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • N-Oleoylphenylalanine | Endogenous Uncoupler of Mitochondrial Respiration
    CAS:
    136560-78-6
    Catalog Number:
    10-1602
    Activity:
    Endogenous Uncoupler of Mitochondrial Respiration
    Chemical Name:
    N-Oleoyl Phe
    Alternate Names:
    NOPA, C18-1-Phe
    Molecular Weight:
    429.64
    Molecular Formula:
    C27H43NO3
    Solubility:
    Soluble in DMSO (up to 35 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:

    Blue Ice

View All Mitochondrial Transporters Products

Oxidative Phosphorylation / Respiratory Chain

  • Citreoviridin | Mitochondrial and Ectopic ATPase inhibitor
    CAS:
    25425-12-1
    Catalog Number:
    10-2065
  • BML-260 | JSP-1 phosphatase inhibitor
    CAS:
    101439-76-3
    Catalog Number:
    10-5153
    Activity:
    JSP-1 phosphatase inhibitor
    Chemical Names:
    (Z)-4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)benzoic acid
    Molecular Weight:
    341.40
    Molecular Formula:
    C17H11NO3S2
    Solubility:
    Soluble in DMSO (45 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • PF-4708671 dihydrochloride | S6K1 inhibitor
    CAS:
    125517-76-0 (free base)
    Catalog Number:
    10-4856
    Activity:
    S6K1 inhibitor
    Chemical Names:
    2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzimidazole dihydrochloride
    Molecular Weight:
    463.33
    Molecular Formula:
    C19H21F3N6·2HCl
    Solubility:
    Soluble in DMSO (at least 35 mg/ml); Water (at least 50 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 1 month. Hygroscopic solid – protect from moisture.
    Shipping Code:
    RT
  • Ascochlorin | Mitochondrial cytochrome bc1 complex inhibitor
    CAS:
    26166-39-2
    Catalog Number:
    10-5296
  • iPHF8 | Inhibitor of lysine demethylase PHF8
    CAS:
    1574530-99-6
    Catalog Number:
    10-4049
View All Oxidative Phosphorylation / Respiratory Chain Products

ROS

  • iPHF8 | Inhibitor of lysine demethylase PHF8
    CAS:
    1574530-99-6
    Catalog Number:
    10-4049
  • Visomitin | Mitochondria-targeted antioxidant
    CAS:
    934826-68-3
    Catalog Number:
    10-3913
  • IACS-010759 | Mitochondrial Complex I Inhibitor
    CAS:
    1570496-34-2
    Catalog Number:
    10-4475
  • Honokiol | SIRT3 activator
    CAS:
    35354-74-6
    Catalog Number:
    10-2311
    Activity:
    SIRT3 activator
    Chemical Names:
    3’,5-Diallyl-[1,1’-biphenyl]-2,4’-diol
    Alternate Name:
    NSC-293100
    Molecular Weight:
    266.34
    Molecular Formula:
    C18H18O2
    Solubility:
    Soluble in DMSO (50 mg/ml)
    Physical Properties:
    Beige solid
    Purity:
    >98% TLC/GC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • BGP-15 | Cellular protectant
    CAS:
    66611-37-8
    Catalog Number:
    10-1373
    Activity:
    Cellular protectant
    Chemical Names:
    N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide, dihydrochloride
    Molecular Weight:
    351.28
    Molecular Formula:
    C14H22N4O2·2HCl
    Solubility:
    Soluble in Water (70 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at room temperature for up to 1 month.
    Shipping Code:
    RT
View All ROS Products

Targeted Reagents

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