Neurotransmitters

Neurotransmitters are peptides (opioids), monoamines (serotonin, dopamine), amino acids (glutamine), or other small molecules (GABA, acetylcholine, ATP, NO). They are stored and released by neurons to effect signals via binding to receptors on other neurons. These signals can be disrupted or enhanced in disease, and they can be modulated by drugs. Focus Biomolecules offers agonists, antagonists, precursors, and metabolites for neurotransmitter research.

Dopamine

  • Thiothixene | Typical antipsychotic/efferocytosis stimulator
    CAS:
    3313-26-6
    Catalog Number:
    10-3998
  • 6,7-ADTN HBr | Dopamine receptor agonist
    CAS:
    13575-86-5
    Catalog Number:
    10-1607
  • Bupropion HCl | Monoamine transporter inhibitor
    CAS:
    31677-93-7
    Catalog Number:
    10-2462
    Activity:
    Monoamine transporter inhibitor
    Chemical Names:
    1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride
    Molecular Weight:
    276.20
    Molecular Formula:
    C13H18ClNO·HCl
    Solubility:
    Soluble in DMSO (40 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • 9-Hydroxyrisperidone | Risperidone metabolite
    CAS:
    144598-75-4
    Catalog Number:
    10-2300
    Activity:
    Risperidone metabolite
    Chemical Name:
    3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
    Alternate Name:
    Paliperidone
    Molecular Weight:
    426.48
    Molecular Formula:
    C23H27FN4O3
    Solubility:
    Soluble in DMSO (up to 4 mg/ml).
    Physical Properties:
    White solid
    Purity:
    95% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • Safinamide | MAO-B inhibitor; Parkinson’s therapeutic
    CAS:
    133865-89-1
    Catalog Number:
    10-2924
    Activity:
    MAO-B inhibitor; Parkinson’s therapeutic
    Chemical Name:
    (S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide
    Alternate Name:
    FCE-26743; PNU-151774E; NW-1015
    Molecular Weight:
    302.34
    Molecular Formula:
    C17H19FN2O2
    Solubility:
    Soluble in DMSO (up to 50 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Dopamine Products

GABA

  • Vigabatrin | Anticonvulsant/Analgesic
    CAS:
    68506-86-5
    Catalog Number:
    10-3534
  • Stiripentol | Anticonvulsant/LDHA inhibitor
    CAS:
    49763-96-4
    Catalog Number:
    10-3978
  • Milbemectin | RDL GABA agonist and Glutamate-gated Cl channel activator
    CAS:
    1799297-76-9
    Catalog Number:
    10-5257
  • Flumazenil | Benzodiazepine antagonist
    CAS:
    78755-81-4
    Catalog Number:
    10-1081
    Activity:
    Benzodiazepine antagonist
    Chemical Name:

    8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester

    Alternate Names:

    Ro 1722;  Ro 15-1788

    Molecular Weight:
    303.29
    Molecular Formula:
    C15H14FN3O3
    Solubility:
    Soluble in DMSO (up to 8 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Tiagabine hydrochloride | GABA transporter 1 (GAT1) inhibitor
    CAS:
    145821-59-6
    Catalog Number:
    10-4384
    Activity:
    GABA transporter 1 (GAT1) inhibitor
    Chemical Name:
    (3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid
    Alternate Name:
    NO-328
    Molecular Weight:
    412.00
    Molecular Formula:
    C20H25NO2S2 • HCl
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml), in Ethanol (up to at least 25 mg/ml) or in Water (up to at least 30 mg/ml)
    Physical Properties:
    Off-white or beige solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol, or distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All GABA Products

Metabolism

  • Safinamide | MAO-B inhibitor; Parkinson’s therapeutic
    CAS:
    133865-89-1
    Catalog Number:
    10-2924
    Activity:
    MAO-B inhibitor; Parkinson’s therapeutic
    Chemical Name:
    (S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide
    Alternate Name:
    FCE-26743; PNU-151774E; NW-1015
    Molecular Weight:
    302.34
    Molecular Formula:
    C17H19FN2O2
    Solubility:
    Soluble in DMSO (up to 50 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • ZJ43 | Potent inhibitor of glutamate carboxypeptidases II and III
    CAS:
    723331-20-2
    Catalog Number:
    10-3904
    Activity:
    Potent inhibitor of glutamate carboxypeptidases II and III
    Chemical Name:
    N-[[[(1S)-1-Carboxy-3-methylbutyl]amino]carbonyl]-L-glutamic acid
    Molecular Weight:
    304.30
    Molecular Formula:
    C12H20N2O7
    Solubility:
    Soluble in DMSO (up to at least mg/ml) or in Water (up to at least 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • Rasagiline mesylate | MAO-B inhibitor, neuroprotective
    CAS:
    161735-79-1
    Catalog Number:
    10-2315
    Activity:
    MAO-B inhibitor, neuroprotective
    Chemical Name:
    (1R)-2,3-Dihydro-N-2-propynyl-1H-inden-1-amine methanesulfonate
    Alternate Names:
    TVP-1012; Azilect
    Molecular Weight:
    267.34
    Molecular Formula:
    C12H13N • CH3SO3H
    Solubility:
    Soluble in DMSO (up to 50 mg/ml), in Water (up to 50 mg/ml), or in Ethanol (up to 30 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Tolcapone | COMT inhibitor / TTR aggregation inhibitor
    CAS:
    134308-13-7
    Catalog Number:
    10-3075
    Activity:
    COMT inhibitor / TTR aggregation inhibitor
    Chemical Name:
    (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
    Alternate Names:
    Ro 40-7592
    Molecular Weight:
    273.24
    Molecular Formula:
    C14H11NO5
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Entacapone | COMT inhibitor
    CAS:
    130929-57-6
    Catalog Number:
    10-2025
    Activity:
    COMT inhibitor – anti-Parkinsons
    Chemical Name:
    (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
    Molecular Weight:
    305.29
    Molecular Formula:
    C14H15N3O5
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 3 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Metabolism Products

Norepinephrine

  • ADRIANA | α2B adrenoceptor antagonist
    CAS:
    719277-27-7
    Catalog Number:
    10-4369
  • Tolcapone | COMT inhibitor / TTR aggregation inhibitor
    CAS:
    134308-13-7
    Catalog Number:
    10-3075
    Activity:
    COMT inhibitor / TTR aggregation inhibitor
    Chemical Name:
    (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
    Alternate Names:
    Ro 40-7592
    Molecular Weight:
    273.24
    Molecular Formula:
    C14H11NO5
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Norquetiapine 2HCl | Quetiapine metabolite
    CAS:
    111974-74-4
    Catalog Number:
    10-2588
    Activity:
    Quetiapine metabolite
    Chemical Name:
    11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
    Molecular Weight:
    368.32
    Molecular Formula:
    C17H17N3S • 2HCl
    Solubility:
    Soluble in DMSO, Methanol, Distilled Water
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Norepinephrine Products

Serotonin

  • Tegaserod maleate | 5-HT₄ agonist/YTHDF1 inhibitor
    CAS:
    189188-57-6
    Catalog Number:
    10-4876
  • Thiothixene | Typical antipsychotic/efferocytosis stimulator
    CAS:
    3313-26-6
    Catalog Number:
    10-3998
  • Ketanserin tartrate | Serotonin 5-HT2A antagonist
    CAS:
    83846-83-7
    Catalog Number:
    10-2490
  • Serodolin | ß-Arrestin-biased 5-HT7 antagonist
    CAS:
    1814929-81-1
    Catalog Number:
    10-4086
    Activity:
    ß-Arrestin-biased 5-HT7 antagonist
    Chemical Names:
    1-(5-(4-(4-Fluorophenyl)piperazin-1-yl)pentyl)-1H-benzo[d]imidazole-2(3H)-one
    Molecular Weight:
    382.47
    Molecular Formula:
    C22H27FN4O
    Solubility:
    Soluble in DMSO (at least 50 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Dihydroergotamine mesylate | Vascular serotonin receptor agonist
    CAS:
    6190-39-2
    Catalog Number:
    10-3400
    Activity:
    Vascular serotonin receptor agonist
    Chemical Names:
    (5’a,10a)-9,10-Dihydro-12′-hydroxy-2′-methyl-5′-(phenylmethyl)ergotaman-3′,6′,18-trione, mesylate
    Molecular Weight:
    679.79
    Molecular Formula:
    C33H37N5O5·CH3SO3H
    Solubility:
    Soluble in DMSO (25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All Serotonin Products