June 22, 2022
Kumar et al. and Zijlmans et al. have published in Nature Cell Biology that Polycomb repressive complex 2 (PRC2) epigenetically reduces lineage potential of hESCs. They […]
June 15, 2022
JTE-607, a cell-permeable prodrug which is converted to its active COOH form via intracellular esterases, was originally found to inhibit cytokine release but its mechanism of […]
June 3, 2022
A team headed by distinguished neuroscientist Alcino Silva recently showed that expression of C-C chemokine receptor type 5 (CCR5) expression reduced memory recall, and maraviroc (Focus […]
May 23, 2022
Perylenequinones are a family of structurally novel fungal or plant natural products which act as photosensitizers. They absorb light energy, enabling them to generate reactive oxygen […]
May 12, 2022
In Nature Communications, Zhang et al. show that DJ001, a selective allosteric inhibitor of protein tyrosine phosphatase sigma (PTPσ), promotes hematopoietic stem cell (HSC) regeneration. Treatment […]
April 27, 2022
CHIR-99021 is another popular tool for stem cell maintenance which increases cell survival and proliferation. It is a GSK3β inhibitor, and Komiya et al. used CHIR-99021 […]
April 14, 2022
The compound Y-27632 inhibits ROCK family kinases and is a very popular tool for embryonic stem cell (ESC) maintenance because it enhances survival and proliferation in […]
April 8, 2022
Ferroptosis is a type of cell death caused by iron-dependent peroxidation of phospholipids and is important for proper function of tumor suppression, immune surveillance, and the […]
