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  • Focus Biomolecules supplier, chemical structure of (±) Tranylcypromine hemisulfate | Demethylase inhibitor | CAS 13492-01-8
    (±) Tranylcypromine hemisulfate | Demethylase inhibitor
    $40.00
    Tranylcypromine (13492-01-8) is an irreversible and non-selective monoamine oxidase inhibitor.1,2 It has been shown to inhibit the histone demethylase BHC110/LSD1.3,4 References/Citations1) Knoll et al. (1980), Monoamine...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 1-EBIO | K+ channel activator | CAS 10045-45-1
    1-EBIO | K+ channel activator; Promotes cardiomyocyte differentiation
    $40.00
    1-EBIO (10045-45-1) is a direct activator of small-conductance Ca2+-activated K+ channels (SK) which dose-dependently relaxes rat mesenteric vessels.1  Reverses ischemia-induced cognitive impairment2 and displays...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 1400W | iNOS inhibitor | CAS 214358-33-5
    1400W | iNOS inhibitor
    $40.00
    1400W (214358-33-5) is a potent, tight-binding, slow inhibitor of inducible nitric oxide synthase (iNOS). Highly selective for iNOS3 (Ki = 7 nM) over nNOS or eNOS (Ki's of 2 μM and 50 μM respectively).1 1400W is cell...

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  • Focus Biomolecules chemical structure 2'-Deoxy-5-fluorocytidine | DNA methyl transferase inhibitor | CAS 10356-76-0
    2'-Deoxy-5-fluorocytidine | Irreversible DNA methyl transferase inhibitor
    $52.00
    2'-Deoxy-5-fluorocytidine (10356-76-0) is a DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors1. Like 5'-Azacytidine (Cat.# 10-1267) and decitabine (Cat.# 10-2412),...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 2-APB | TRP activator | CAS 524-95-8
    2-APB | TRP activator
    $25.00
    2-APB (524-95-8) is an IP3 receptor antagonist (IC50=42 μM).1 Inhibits store-operated Ca2+ channels at high concentrations (50 μM) but stimulates at low concs. (<10 μM).2 Modulates TRP channels,...

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  • Focus Biomolecules supplier, chemical structure of 27-Hydroxycholesterol | Cholesterol oxidation metabolite | CAS 20380-11-4
    27-Hydroxycholesterol | Cholesterol oxidation metabolite
    $40.00
    27-Hydroxycholesterol (20380-11-4) is a metabolite resulting from the action of sterol 27-hydroxylase on cholesterol. Concentrations of 27-hydroxycholesterol are elevated in patients with Alzheimers disease and mild...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 2GBI | Hv1 channel blocker | CAS 5418-95-1
    2GBI | Hv1 channel blocker
    $50.00
    2GBI (5418-95-1) is a selective and state-dependent blocker of voltage-gated proton channels (Hv1).1 2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side.2,3  Inhibition of Hv1 is...

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  • Focus Biomolecules cell signaling supplier, chemical structure of 3-Methyladenine | Autophagosome inhibitor | CAS 5142-23-4
    3-Methyladenine | Autophagosome inhibitor
    $30.00
    3-Methyladenine (5142-23-4) inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K)1,2. Protects 1321N1 astrocytoma cells against pyocyanin and...

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  • Focus Biomolecules supplier, chemical structure 4,9-Anhydrotetrodotoxin | Selective sodium channel blocker | CAS 13072-89-4
    4,9-Anhydrotetrodotoxin | Selective sodium channel blocker
    $125.00
    4,9-Anhydrotetrodotoxin (13072-89-4) is a highly selective blocker of the Na(v1.6) sodium channel. (IC50's: Na(v1.2) = 260 nM, Na(v1.3) = 341 nM, Na(v1.4) = 988 nM, Na(v1.5) = 11.6 μM, Na(v1.6) = 7.8 nM, Na(v1.7) = 1.27...

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  • Focus Biomolecules cell signaling reagent supplier, structure of 5-Azacytidine | DNA hypomethylation agent | CAS 320-67-2
    5-Azacytidine | DNA hypomethylation agent
    $20.00
    5-Azacytidine (320-67-2) is specific inhibitor of DNA methyltransferase1. Incorporates into DNA and covalently reacts with and inhibits DNA methyltransferases. Induces demethylation and reactivation of silenced genes2...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure 6,7-ADTN HBr | Dopamine D1 agonist | CAS 13575-86-5
    6,7-ADTN HBr | Dopamine D1 agonist
    $60.00
    6,7-ADTN HBr (13575-86-5) is a broad spectrum dopamine receptor agonist.1,2  Demonstrates a marked selectivity for the human dopamine D3 receptor.3 6,7-ADTN and psychostimulants such as cocaine and amphetamine reduce...

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  • 9-Hydroxyrisperidone | Risperidone metabolite
    9-Hydroxyrisperidone | Risperidone metabolite
    $30.00
    9-Hydroxyrisperidone (144598-75-4) is a pharmacologically active metabolite of risperidone, an atypical antipsychotic agent.1 Displays high affinity for serotonin 5-HT2A receptors as well as dopamine D2 receptors...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of A-803467 | NaV1.8 blocker | CAS 944261-79-4
    A-803467 | NaV1.8 blocker
    $67.00
    A-803467 (944261-79-4) is a potent, selective inhibitor of the TTX-resistant voltage-gated sodium channel Nav1.8. Nav1.8 is preferentially expressed in sensory neurons, and inhibition attenuates both inflammatory and...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of A-967079 | TRPA1 blocker | CAS 1170613-55-4
    A-967079 | TRPA1 blocker
    $78.00
    A-967079 (1170613-55-4) is a TRPA1 antagonist. Active in rat models.1 Cell permeable References/Citations1) McGaraughty et al. (2010), TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in...

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  • Focus Biomolecules supplier, chemical structure of ABT-418 HCl | Nicotinic acetylcholine receptor agonist | CAS 147388-83-8
    ABT-418 HCl | Nicotinic acetylcholine receptor agonist; cognition enhancer
    $90.00
    ABT-418 (CAS 147388-83-8) is an agonist at neuronal nicotinic acetylcholine receptors displaying the highest potency at α4β2 and α2β2 subtypes (EC50= approximately 6 and 11 μM, respectively).1...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AK-7 | SIRT2 inhibitor | CAS 420831-40-9
    AK-7 | SIRT2 inhibitor
    $50.00
    AK-7 (420831-40-9) is a selective Sirt2 inhibitor (IC50=15.5 μM) which does not inhibit Sirt1 or Sirt3.1 It down regulates cholesterol biosynthesis genes in primary striatal neurons.1 AK-7 displays...

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  • Allopregnanolone | GABA-A positive allosteric modulator
    Allopregnanolone | GABA-A positive allosteric modulator
    $70.00
    Allopregnanolone (516-54-1) is an endogenous neurosteroid which acts as a positive allosteric modulator of GABAA receptors.1,2 Recently FDA approved (Brexanolone) for postpartum depression.3 Inhibits TLR4 receptor activation...

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  • Focus Biomolecules supplier, chemical structure of AM-404 | Anandamide transport inhibitor | CAS 198022-70-7
    AM-404 | Anandamide transport inhibitor
    $40.00
    AM-404 (198022-70-7) inhibits anandamide transport (IC50 = 1 μM) without inhibiting anandamide amidase or activating cannabinoid receptors.1,2 Vanilloid receptors are activated by AM-404.3 Active in vivo...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure AM251 | Cannabinoid CB1 antagonist | CAS 183232-66-8
    AM251 | Cannabinoid CB1 antagonist
    $72.00
    AM251 (183232-66-8) is a potent cannabinoid CB1 receptor antagonist with selectivity over CB2 receptors (306-fold).1-3 Displays anorectic effects and antidepressant-like effects in mice.4 Behaves as an agonist at GPR55,...

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  • Focus Biomolecules cell signaling tech supplier, chemical structure Ambroxol HCl | Free radical scavenger | CAS 18683-91-5
    Ambroxol HCl | Free radical scavenger
    $50.00
    Ambroxol HCl (18683-91-5) is a radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveolar lavage cells, inhibits doxorubicin-induced lipid peroxidation (70 mg/kg in...

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