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  • (±) Tranylcypromine hemisulfate | Demethylase inhibitor
    (±) Tranylcypromine hemisulfate | Demethylase inhibitor
    $40.00
    Tranylcypromine (13492-01-8) is an irreversible and non-selective monoamine oxidase inhibitor.1,2 It has been shown to inhibit the histone demethylase BHC110/LSD1.3,4 References/Citations1) Knoll et al. (1980), Monoamine...

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  • 1-EBIO | K+ channel activator; Promotes cardiomyocyte differentiation
    1-EBIO | K+ channel activator; Promotes cardiomyocyte differentiation
    $40.00
    1-EBIO (10045-45-1) is a direct activator of small-conductance Ca2+-activated K+ channels (SK) which dose-dependently relaxes rat mesenteric vessels.1  Reverses ischemia-induced cognitive impairment2 and displays...

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  • 1400W | iNOS inhibitor
    1400W | iNOS inhibitor
    $40.00
    1400W (214358-33-5) is a potent, tight-binding, slow inhibitor of inducible nitric oxide synthase (iNOS). Highly selective for iNOS3 (Ki = 7 nM) over nNOS or eNOS (Ki's of 2 μM and 50 μM respectively).1 1400W is cell...

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  • 2'-Deoxy-5-fluorocytidine | Irreversible DNA methyl transferase inhibitor
    2'-Deoxy-5-fluorocytidine | Irreversible DNA methyl transferase inhibitor
    $52.00
    2'-Deoxy-5-fluorocytidine (10356-76-0) is a DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors1. Like 5'-Azacytidine (Cat.# 10-1267) and decitabine (Cat.# 10-2412),...

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  • 2-APB | 524-95-8 | Structure | Supplier
    2-APB | TRP activator
    $25.00
    2-APB (524-95-8) is an IP3 receptor antagonist (IC50=42 μM).1 Inhibits store-operated Ca2+ channels at high concentrations (50 μM) but stimulates at low concs. (<10 μM).2 Modulates TRP channels,...

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  • 27-Hydroxycholesterol | Cholesterol oxidation metabolite
    27-Hydroxycholesterol | Cholesterol oxidation metabolite
    $40.00
    27-Hydroxycholesterol (20380-11-4) is a metabolite resulting from the action of sterol 27-hydroxylase on cholesterol. Concentrations of 27-hydroxycholesterol are elevated in patients with Alzheimers disease and mild...

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  • 2GBI | Hv1 channel blocker
    2GBI | Hv1 channel blocker
    $50.00
    2GBI (5418-95-1) is a selective and state-dependent blocker of voltage-gated proton channels (Hv1).1 2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side.2,3  Inhibition of Hv1 is...

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  • 3-Methyladenine | Autophagosome inhibitor
    3-Methyladenine | Autophagosome inhibitor
    $44.00
    3-Methyladenine (5142-23-4) inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K)1,2. Protects 1321N1 astrocytoma cells against pyocyanin and...

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  • 4,9-Anhydrotetrodotoxin | Selective sodium channel blocker
    4,9-Anhydrotetrodotoxin | Selective sodium channel blocker
    $125.00
    4,9-Anhydrotetrodotoxin (13072-89-4) is a highly selective blocker of the Na(v1.6) sodium channel. (IC50's: Na(v1.2) = 260 nM, Na(v1.3) = 341 nM, Na(v1.4) = 988 nM, Na(v1.5) = 11.6 μM, Na(v1.6) = 7.8 nM, Na(v1.7) = 1.27...

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  • 5-Azacytidine | 320-67-2 | Structure | Supplier
    5-Azacytidine | DNA hypomethylation agent
    $20.00
    5-Azacytidine (320-67-2) is specific inhibitor of DNA methyltransferase1. Incorporates into DNA and covalently reacts with and inhibits DNA methyltransferases. Induces demethylation and reactivation of silenced genes2...

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  • 6,7-ADTN HBr | 13575-86-5 | Structure | Supplier
    6,7-ADTN HBr | Dopamine D1 agonist
    $60.00
    6,7-ADTN HBr (13575-86-5) is a broad spectrum dopamine receptor agonist.1,2  Demonstrates a marked selectivity for the human dopamine D3 receptor.3 6,7-ADTN and psychostimulants such as cocaine and amphetamine reduce...

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  • A-803467 | 944261-79-4 | Structure | Supplier
    A-803467 | NaV1.8 blocker
    $67.00
    A-803467 (944261-79-4) is a potent, selective inhibitor of the TTX-resistant voltage-gated sodium channel Nav1.8. Nav1.8 is preferentially expressed in sensory neurons, and inhibition attenuates both inflammatory and...

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  • A-967079 | 1170613-55-4 | Structure | Supplier
    A-967079 | TRPA1 blocker
    $78.00
    A-967079 (1170613-55-4) is a TRPA1 antagonist. Active in rat models.1 Cell permeable References/Citations1) McGaraughty et al. (2010), TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in...

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  • ABT-418 HCl | Nicotinic acetylcholine receptor agonist; cognition enhancer
    ABT-418 HCl | Nicotinic acetylcholine receptor agonist; cognition enhancer
    $90.00
    Agonist at neuronal nicotinic acetylcholine receptors displaying the highest potency at α4β2 and α2β2 subtypes (EC50= approximately 6 and 11 μM, respectively).1 Displays anxiolytic activity in a rat...

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  • AK-7 | 420831-40-9 | Structure | Supplier
    AK-7 | SIRT2 inhibitor
    $50.00
    AK-7 (420831-40-9) is a selective Sirt2 inhibitor (IC50=15.5 μM) which does not inhibit Sirt1 or Sirt3.1 It down regulates cholesterol biosynthesis genes in primary striatal neurons.1 AK-7 displays...

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  • AM-404 | 198022-70-7 | Structure | Supplier
    AM-404 | Anandamide transport inhibitor
    $40.00
    AM-404 (198022-70-7) inhibits anandamide transport (IC50 = 1 μM) without inhibiting anandamide amidase or activating cannabinoid receptors.1,2 Vanilloid receptors are activated by AM-404.3 Active in vivo...

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  • AM251 | Cannabinoid CB1 antagonist
    AM251 | Cannabinoid CB1 antagonist
    $72.00
    AM251 (183232-66-8) is a potent cannabinoid CB1 receptor antagonist with selectivity over CB2 receptors (306-fold).1-3 Displays anorectic effects and antidepressant-like effects in mice.4 Behaves as an agonist at GPR55,...

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  • Ambroxol HCl | Free radical scavenger
    Ambroxol HCl | Free radical scavenger
    $50.00
    Ambroxol HCl (18683-91-5) is a radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveolar lavage cells, inhibits doxorubicin-induced lipid peroxidation (70 mg/kg in...

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  • Amlodipine | 88150-42-9 | Structure | Supplier
    Amlodipine | L-type Ca channel blocker
    $59.00
    Amlodipine (88150-42-9) is an anti-hypertensive L-type calcium channel blocker, which also benefits the cardiovascular system by stimulating nitric oxide synthase, inhibiting angiotension-induced oxidative stress and...

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  • ANA-12 | TrkB antagonist
    ANA-12 | TrkB antagonist
    $87.00
    ANA-12 (219755-25-3) is a TrkB receptor antagonist. Binds to two distinct receptor sites preventing activation by BDNF non-competitively, IC50 = 45.6 nM and 41.1 μM for the high and low affinity sites respectively...

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