Neurosciences
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Showing 1–12 of 312 results
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Dedifferentiation
(±) Tranylcypromine hemisulfate | Demethylase inhibitor
Tranylcypromine (13492-01-8) is an irreversible and non-selective monoamine oxidase inhibitor.1,2 It has been shown to inhibit the histone demethyl...$40.00 – $150.00 Select options -
Cardiovascular
1-EBIO | K+ channel activator; Promotes cardiomyocyte differentiation
1-EBIO (10045-45-1) is a direct activator of small-conductance Ca2+-activated K+ channels (SK) which dose-dependently relaxes rat mesenteric vessel...$40.00 – $148.00 Select options -
Neurosciences
1400W | iNOS inhibitor
1400W (214358-33-5) is a potent, tight-binding, slow inhibitor of inducible nitric oxide synthase (iNOS). Highly selective for iNOS3 (Ki = 7 nM) ov...$40.00 – $145.00 Select options -
Ion channels
2-APB | TRP channel blocker
2-APB (524-95-8) is an IP3 receptor antagonist (IC50=42 μM).1 Inhibits store-operated Ca2+ channels at high concentrations (50 μM) but stimulates a...$25.00 – $50.00 Select options -
Cancer
2′-Deoxy-5-fluorocytidine | Irreversible DNA methyl transferase inhibitor
2'-Deoxy-5-fluorocytidine (10356-76-0) is a DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors.1...$52.00 – $208.00 Select options -
Cell Death
24(S)-Hydroxycholesterol | Endogenous cholesterol metabolite
24(S)-Hydroxycholesterol (474-73-7) is an important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain.1 It is an endogenous ag...$50.00 – $245.00 Select options -
Alzheimers
27-Hydroxycholesterol | Cholesterol oxidation metabolite
27-Hydroxycholesterol (20380-11-4) is a metabolite resulting from the action of sterol 27-hydroxylase on cholesterol. Concentrations of 27-hydroxyc...$40.00 – $175.00 Select options -
Ion channels
2GBI | Hv1 channel blocker
2GBI (5418-95-1) is a selective and state-dependent blocker of voltage-gated proton channels (Hv1).1 2GBI blocks the channel by binding to the volt...$50.00 – $100.00 Select options -
Autophagy
3-Methyladenine | Autophagosome inhibitor
3-Methyladenine (5142-23-4) inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K...$30.00 – $90.00 Select options -
Ion channels
4,9-Anhydrotetrodotoxin | Selective sodium channel blocker
4,9-Anhydrotetrodotoxin (13072-89-4) is a highly selective blocker of the Na(v1.6) sodium channel. (IC50's: Na(v1.2) = 260 nM, Na(v1.3) = 341 nM, N...$125.00 – $995.00 Select options -
Cancer
5-Azacytidine | DNA hypomethylation agent
5-Azacytidine (320-67-2) is specific inhibitor of DNA methyltransferase.1 Incorporates into DNA and covalently reacts with and inhibits DNA methylt...$20.00 – $80.00 Select options -
Dopamine
6,7-ADTN HBr | Dopamine D1 agonist
6,7-ADTN HBr (13575-86-5) is a broad spectrum dopamine receptor agonist.1,2 Demonstrates a marked selectivity for the human dopamine D3 receptor.3...$60.00 – $260.00 Select options
