Intelliscreen™ Wnt/β-catenin (canonical) Mini-Library
The Wnt/ß-catenin pathway is a multi-component pathway primarily involved in embryonic development, adult tissue homeostasis, and cell proliferation. Wnt proteins (i.e Wnt1, Wnt3a, Wnt5a) mediate extracellular signals that activate Wnt membrane receptors Frizzled and LRP5/6. Once activated, these signals inactivate a ß-catenin degradation complex allowing ß-catenin to translocate to the nucleus where it binds to TCF enabling target gene transcription. Dysfunction in the Wnt/ß-catenin pathway is implicated in various cancers, liver disease, ALS, Alzheimer’s disease, bone disease, and cardiovascular disease. The IntelliscreenTM Wnt/ß-Catenin mini-library includes inhibitors of various Wnt pathway members including Porcupine, Tankyrase, Frizzled, V-ATPase, Disheveled, CREB-binding protein, and others.
Catalog Number:
10-7305
Description:
12 inhibitors of the various components of this pathway.
Solubility:
DMSO
Supplied As:
DMSO solution @ 10mM
Storage Temperature:
-80°C
Stability:
Stable for up to 1 year when stored as supplied @ -80°C
Price:
$475.00
In Stock
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
The Wnt/ß-Catenin mini-library includes the following components for studying the important areas of this pathway.
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Bafilomycin A1 | Vacuolar H+ ATPase inhibitor
From $40.00CAS:88899-55-2Catalog Number:10-2060Activity:Vascular H+-ATPase inhibitorMolecular Weight:622.84Molecular Formula:C35H58O9Solubility:Soluble in DMSO (up to 5 mg/ml, with warming).Physical Properties:Off-white or yellow filmPurity:95% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
BC2059 | Beta-catenin inhibitor
CAS:1227637-23-1Catalog Number:10-4642Molecular Weight:588.74 -
ICG-001 | Wnt beta-catenin inhibitor
From $65.00CAS:847591-62-2Catalog Number:10-4378Activity:Wnt β-catenin inhibitorChemical Name:(6S,9aS)-Hexahydro-6-[(4-hydroxypheny;)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H- pyrazine[1,2-a]pyrimidine-1(6H)-carboxamideMolecular Weight:548.63Molecular Formula:C33H32N4O4Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:Off-white solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
iCRT5 | Beta-catenin inhibitor
From $57.00CAS:18623-44-4Catalog Number:10-1371Activity:Beta-catenin inhibitorChemical Name:4-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-butyric acidMolecular Weight:367.44Molecular Formula:C16H17NO5S2Solubility:Soluble in DMSO (up to 30 mg/ml)Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.Shipping Code:RT -
IWP-2 | Porcn inhibitor: Wnt/Beta-catenin pathway inhibitor
From $55.00CAS:686770-61-6Catalog Number:10-1308Activity:Porcn inhibitor: Wnt/β-catenin pathway inhibitorChemical Name:N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamideMolecular Weight:466.61Molecular Formula:C22H18N4O2S3Solubility:Soluble in DMSO (up to 5 mg/ml, with warming).Physical Properties:Beige solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.Shipping Code:RT -
IWR-1 endo | Wnt signaling inhibitor
From $50.00CAS:1127442-82-3Catalog Number:10-5081Activity:Wnt signaling inhibitorMolecular Weight:409.44Molecular Formula:C25H19N3O2Solubility:Soluble in DMSO (up to 10 mg/ml)Physical Properties:Off-white or yellow solidPurity:98% by TLC/HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
JW74
CAS:863405-60-1Catalog Number:10-4646Molecular Weight:456.52 -
KY-02111 | Wnt pathway inhibitor
From $55.00CAS:1118807-13-8Catalog Number:10-1437Activity:Wnt pathway inhibitorChemical Name:N-(6-Chloro-2-benzothiazolyl)-3,4-dimethoxybenzenepropanamideMolecular Weight:376.86Molecular Formula:C18H17ClN2O3SSolubility:Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
Niclosamide | STAT3 signaling inhibitor
From $28.00CAS:50-65-7Catalog Number:10-2474Activity:STAT3 signaling inhibitorChemical Name:5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamideMolecular Weight:327.13Molecular Formula:C13H8Cl2N2O4Solubility:Soluble in DMSO (up to 3 mg/ml), or in Ethanol (up to 6 mg/ml).Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
Nitazoxanide | Wnt signaling inhibitor
From $40.00CAS:55981-09-4Catalog Number:10-4633Activity:Wnt signaling inhibitorChemical Names:O-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenyl acetate; NTZMolecular Weight:307.28Molecular Formula:C12H9N3O5SSolubility:Soluble in DMSO (>50 mg/ml)Physical Properties:Off-white solidPurity:99% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
NSC668036
CAS:144678-63-7Catalog Number:10-4636Molecular Weight:460.52 -
Wnt-C59 | Porcupine Inhibitor
From $50.00CAS:1243243-89-1Catalog Number:10-4605Activity:Porcupine InhibitorChemical Name:4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamideMolecular Weight:379.46Molecular Formula:C25H21N3OSolubility:Soluble in DMSO (up to 7 mg/ml) or in Ethanol (up to 6 mg/mL)Physical Properties:Tan solidPurity:>98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.Shipping Code:RT -
XAV-939 | Tankyrase inhibitor/Cardiomyogenesis inducer
From $50.00CAS:284028-89-3Catalog Number:10-1186Activity:Tankyrase inhibitor / Cardiomyogenesis inducerChemical Name:2-[4-(Trifluoromethyl)phenyl]-7,8-dihydro-5H-thino[4,3-d]pyrimidin-4-olMolecular Weight:312.31Molecular Formula:C14H11F3N2OSSolubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:White or off-white solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.Shipping Code:RT
