Cellular trafficking

Cellular trafficking is the transport of proteins, organelles, and other components within a cell, mediated by the ER, Golgi, cytoskeleton, and plasma membrane. It is integral to processes such as secretion, autophagy, immune and neuronal cell function, cancer cell migration, and stem cell differentiation.

Endocytosis

  • PITSTOP2 | Clathrin-mediated endocystosis inhibitor
    CAS:
    1332879-52-3
    Catalog Number:
    10-4195
  • Rasarfin | Dual Ras/ARF6 inhibitor
    CAS:
    674359-73-0
    Catalog Number:
    10-5498
    Activity:
    Dual Ras/ARF6 inhibitor
    Chemical Names:
    N-(3-Chloro-4-(4-isobutyrylpiperazin-1-yl)phenyl)benzofuran-2-carboxamide
    Molecular Weight:
    425.91
    Molecular Formula:
    C23H24ClN3O3
    Solubility:
    Soluble in DMSO (70 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Prochlorperazine maleate | Endocytosis inhibitor
    CAS:
    84-02-6
    Catalog Number:
    10-3474
    Activity:
    Endocytosis inhibitor
    Chemical Name:
    2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine dimaleate
    Molecular Weight:
    606.09
    Molecular Formula:
    C20H24ClN3S • 2C4H4O4
    Solubility:
    Soluble in DMSO (up to 15 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20° (des.)
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • MiTMAB | Dynamin inhibitor
    CAS:
    1119-97-7
    Catalog Number:
    10-3051
    Activity:
    Dynamin inhibitor
    Chemical Name:
    Tetradecyltrimethylammonium bromide
    Alternate Names:
    Myristyltrimethylammonium bromide, MTAB, TTAB
    Molecular Weight:
    336.39
    Molecular Formula:
    C17H38BrN
    Solubility:
    Soluble in DMSO (up to 10 mg/ml), in Ethanol (up to 60 mg/ml) or in Water (up to 30 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol, or distilled water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Dynasore | Dynamin inhibitor
    CAS:
    304448-55-3
    Catalog Number:
    10-1427
    Activity:
    Dynamin inhibitor
    Chemical Name:
    3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide
    Molecular Weight:
    322.32
    Molecular Formula:
    C18H14N2O4
    Solubility:
    Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 1 mg/ml).
    Physical Properties:
    Beige solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All Endocytosis Products

ER / Golgi

  • Monensin Na | Golgi transport inhibitor
    CAS:
    22373-78-0
    Catalog Number:
    10-2659
    Activity:
    Golgi transport inhibitor
    Chemical Names:
    2-[5-Ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-hydroxymethyl-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β-methoxy-α,γ,2,8-tetramethyl-1,6-dioxaspiro[4.5]decane-7-butyric acid, sodium salt
    Alternate Name:
    NSC-343257
    Molecular Weight:
    692.86
    Molecular Formula:
    C36H61O11·Na
    Solubility:
    Soluble in DMSO (25 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    90-95% TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Exo2 | GBF1 inhibitor – induces Golgi disassembly
    CAS:
    304684-77-3
    Catalog Number:
    10-1594
    Activity:
    GBF1 inhibitor – induces Golgi disassembly
    Chemical Name:
    2-Methoxy-4-[(5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol
    Molecular Weight:
    354.43
    Molecular Formula:
    C18H18N4O2S
    Solubility:
    Soluble in DMSO (up to 25 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • CT-2584 | Inhibitor of CTP: choline-phosphate cytidylyltransferase
    CAS:
    166981-13-1 (free base)
    Catalog Number:
    10-4560
    Activity:
    Inhibitor of CTP: choline-phosphate cytidylyltransferase
    Chemical Name:
    1-(11-Dodecylamino-10-hydroxyundecyl)-3,7-dimethylxanthine methane sulfonate
    Molecular Weight:
    629.9
    Molecular Formula:
    C30H55N5O3 CH3SO3H
    Solubility:
    Soluble in DMSO (up to 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Nocodazole | Microtubule inhibitor
    CAS:
    31430-18-9
    Catalog Number:
    10-2387
    Activity:
    Microtubule inhibitor/CRISPR enhancer
    Alternate Names:
    R-17934
    Chemical Name:
    Methyl[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate
    Molecular Weight:
    301.32
    Molecular Formula:
    C14H11N3O3S
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    White or off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT (des.)
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • STF-083010 | IRE1 inhibitor
    CAS:
    307543-71-1
    Catalog Number:
    10-1510
    Activity:
    Inhibits IRE1
    Chemical Name:
    N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide
    Molecular Weight:
    317.39
    Molecular Formula:
    C15H11NO3S2
    Solubility:
    Soluble in DMSO (up to 30 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All ER / Golgi Products

Exocytosis

  • Endosidin 2 | Exocytosis and endosomal recycling inhibitor
    Catalog Number:
    10-1583
    CAS#:
    1839524-44-5
    Activity:
    Exocytosis and endosomal recycling inhibitor
    Chemical Name:
    (E)-3-Fluoro-N’-(4-hydroxy-3-iodo-5-methoxybenzylidene)benzohydrazide
    Molecular Weight:
    414.17
    Molecular Formula:
    C15H12FIN2O3
    Solubility:
    Soluble in DMSO (greater than 40 mg/ml), in DMF (up to 35 mg/ml) or in Ethanol (up to 10 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Exocytosis Products

Nuclear Export

  • BTB-1 | Mitotic kinesin Kif18A inhibitor
    CAS:
    86030-08-2
    Catalog Number:
    10-1543
    Activity:
    Mitotic kinesin Kif18A inhibitor
    Chemical Names:
    4-Chloro-2-nitro-1-(phenylsulfonyl)benzene; NSC 156750
    Molecular Weight:
    297.71
    Molecular Formula:
    C12H8ClNO4S
    Solubility:
    Soluble in DMSO (30 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    Room temperature
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Selinexor | Inhibitor of the nuclear export receptor CRM1/XPO1
    CAS:
    1393477-72-9
    Catalog Number:
    10-4011
    Activity:
    Inhibitor of the nuclear export receptor CRM1/XPO1
    Chemical Name:
    (Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N’-pyrazin-2-ylprop-2-enehydrazide
    Alternate Name:
    KPT-330
    Molecular Weight:
    443.31
    Molecular Formula:
    C17H11F6N7O
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml). or in Ethanol (up to at least 25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • Leptomycin B | Nuclear export inhibitor
    CAS:
    87081-35-4
    Catalog Number:
    10-2084
    Activity:
    Nuclear export inhibitor
    Molecular Weight:
    540.75
    Molecular Formula:
    C33H48O6
    Solubility:
    Supplied in solution in ethanol (1 mg/ml). Further dilutions may be made with either ethanol or DMSO.
    Physical Properties:
    Solution in ethanol (1mg/ml)
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions or dilutions in DMSO are not stable. Solutions should be made fresh and used within one working day.
    Shipping Code:
    RT
View All Nuclear Export Products

Nuclear Import

  • Ivermectin | Nuclear transport inhibitor
    CAS:
    70288-86-7
    Catalog Number:
    10-2628
    Activity:
    Nuclear transport inhibitor
    Chemical Name:
    22,23-Dihydroavermectin B1
    Alternate Name:
    22,23-Dihydro C076B1; MK-933
    Molecular Weight:
    875.09
    Molecular Formula:
    C48H74O14 (B1a form)
    Solubility:
    Soluble in DMSO (up to 70 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Contains up to 10% B1b form
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Importazole | Blocks importin-ß-mediated nuclear import
    CAS:
    662163-81-7
    Catalog Number:
    10-1412
    Activity:
    Blocks importin-β-mediated nuclear import
    Alternate Names:
    IPZ
    Chemical Name:
    N-(1-Phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine
    Molecular Weight:
    318.43
    Molecular Formula:
    C20H22N4
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    97% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Nuclear Import Products

Other Cellular Trafficking

  • MitoBloCK-10 | TIMM44 blocker
    CAS:
    394694-98-5
    Catalog Number:
    10-5324
  • SLB1122168 | Sphingosine-1-phosphate transport inhibitor
    CAS:
    2999629-17-1 |
    Catalog Number:
    10-4396
  • EGA | Endosomal trafficking inhibitor
    CAS:
    415687-81-9
    Catalog Number:
    10-3689
    Activity:
    Endosomal trafficking inhibitor
    Chemical Names:
    2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide
    Molecular Weight:
    346.23
    Molecular Formula:
    C16H16BrN3O
    Solubility:
    Soluble in DMSO (50 mg/ml); Ethanol (10 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    >95% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Concanamycin A | V-ATPase inhibitor
    CAS:
    80890-47-7
    Catalog Number:
    10-2905
    Activity:
    V-ATPase inhibitor
    Alternate Name:
    Folimycin
    Molecular Weight:
    866.09
    Molecular Formula:
    C46H75NO14
    Solubility:
    Soluble in DMSO
    Physical Properties:
    White solid or lyophilized solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • SGC-GAK-1 | Potent and selective Cyclin G Associated Kinase (GAK) inhibitor
    CAS:
    2226517-76-4
    Catalog Number:
    10-4796
    Activity:
    Potent and selective Cyclin G Associated Kinase (GAK) inhibitor
    Chemical Name:
    6-Bromo-N-(3,4,5-trimethoxyphenyl)quinoline-4-amine
    Molecular Weight:
    389.25
    Molecular Formula:
    C18H17BrN2O3
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 10 mg/ml)
    Physical Properties:
    Pale yellow solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
View All Other Cellular Trafficking Products

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