Glyco processing

Glycosylation is the enzymatic addition of carbohydrate chains to proteins or lipids in cells. Carbohydrate chains vary greatly in composition and length and are often branched. Glycosylation (and deglycosylation) play roles in protein and lipid conformation, interaction, function, and stability.

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Fucosidase

Glucosidase

Miglustat HCl | Alpha-glucosidase inhibitor

CAS:

210110-90-0

Catalog Number:

10-2413

Activity:

Alpha-glucosidase inhibitor

Chemical Name:

N-Butyldeoxynojirimycin HCl

Alternate Names:

NB-DNJ

Molecular Weight:

255.74

Molecular Formula:

C₁₀H₂₁NO₄ • HCL

Solubility:

Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml)

Physical Properties:

White solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.

Shipping Code:

Isofagomine tartrate | Glucocerebrosidase activator and chaperone

CAS:

957230-65-8

Catalog Number:

10-2859

Activity:

Glucocerebrosidase activator and chaperone

Chemical Name:

(3R,4R,5R)-5-Hydroxymethyl-3,5-piperidinediol tratrate

Molecular Weight:

297.26

Molecular Formula:

C₆H₁₃NO₃ • C₄H₆O₆

Solubility:

Soluble in DMSO (up to 2 mg/ml)

Physical Properties:

Off-white solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Shipping Code:

Deoxynojirimycin | Glucosidase inhibitor

CAS:

19130-96-2

Catalog Number:

10-2409

Activity:

Glucosidase inhibitor

Chemical Name:

(2R,3R,4R,5S)-2-(Hydroxymethyl)-3,4,5-piperidinetriol

Molecular Weight:

163.17

Molecular Formula:

C₆H₁₃NO₄

Solubility:

Soluble in Water up to 25 mg/ml).

Physical Properties:

White solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.

Shipping Code:

Mannosidase

Deoxymannojirimycin HCl | Mannosidase inhibitor

CAS:

73465-43-7

Catalog Number:

10-2798

Activity:

Mannosidase inhibitor

Chemical Name:

2R-(Hydroxymethyl)-3R,4R,5R-piperidinetriol hydrochloride

Alternate Names:

1,5-Dideoxy-1,5-imino-D-mannitol hydrochloride

Molecular Weight:

199.63

Molecular Formula:

C₆H₁₃NO₄ • HCl

Solubility:

Soluble in Water (up to 5 mg/ml)

Physical Properties:

White solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.

Shipping Code:

Kifunensine | Mannosidase inhibitor

CAS:

109944-15-2

Catalog Number:

10-2860

Activity:

Mannosidase inhibitor

Chemical Name:

(5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione

Alternate Names:

FR-900494

Molecular Weight:

232.19

Molecular Formula:

C₈H₁₂N₂O₆

Solubility:

Soluble in DMSO (up to 35 mg/ml)

Physical Properties:

White solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Shipping Code:

Swainsonine | Glycosidase inhibitor

CAS:

72741-87-8

Catalog Number:

10-2674

Activity:

Glycosidase inhibitor

Chemical Name:

(1S,2R,8R,8aR)-octahydro-1,2,8-indolizinetriol

Molecular Formula:

C₈H₁₅NO₃

Solubility:

Soluble in DMSO (up to 10 mg/ml), in Ethanol (up to 10 mg/ml) or in Water (up to 8 mg/ml)

Physical Properties:

White or off-white solid solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20°C for up to 3 months.

Shipping Code:

Other

Migalastat HCl | Galactosidase inhibitor/Pharmacological chaperone

CAS:

75172-81-5

Catalog Number:

10-2632

4-MUG | ß-Galactosidase fluorogenic substrate

CAS:

6160-78-7

Catalog Number:

10-3879

Activity:

ß-Galactosidase fluorogenic substrate

Chemical Names:

4-Methylumbelliferyl ß-D-galactopyranoside;
4-MU-b-D-Gal; MUgal; MUG; MUGA

Molecular Weight:

338.31

Molecular Formula:

C₁₆H₁₈O₈

Solubility:

Soluble in DMSO (40 mg/ml)

Physical Properties:

White solid

Purity:

97% HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Shipping Code:

IPTG (animal free) | Induces ß-galactosidase in bacteria

CAS:

367-93-1

Catalog Number:

10-2394

Activity:

Induces β-galactosidase in bacteria

Chemical Name:

Isopropyl β-D-thiogalactopyranoside (non-animal origin)

Molecular Weight:

238.3

Molecular Formula:

C₉H₁₈O₅S

Solubility:

Soluble in Water or Methanol.

Physical Properties:

White solid

Purity:

98% by HPLC
NMR (Conforms)Lead < 2ppm
Dioxane – not detected
Water – 0.38% (Karl Fischer)

Storage Temperature:

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in distilled water or methanol may be stored at -20° for up to 3 months.

Shipping Code:

Glyco processing

Glycosylation is the enzymatic addition of carbohydrate chains to proteins or lipids in cells. Carbohydrate chains vary greatly in composition and length and are often branched. Glycosylation (and deglycosylation) play roles in protein and lipid conformation, interaction, function, and stability.

Fucosidase

Glucosidase

Miglustat HCl | Alpha-glucosidase inhibitor

Isofagomine tartrate | Glucocerebrosidase activator and chaperone

Deoxynojirimycin | Glucosidase inhibitor

Mannosidase

Deoxymannojirimycin HCl | Mannosidase inhibitor

Kifunensine | Mannosidase inhibitor

Swainsonine | Glycosidase inhibitor

Other

Migalastat HCl | Galactosidase inhibitor/Pharmacological chaperone

4-MUG | ß-Galactosidase fluorogenic substrate

IPTG (animal free) | Induces ß-galactosidase in bacteria

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

Glyco processing

Glycosylation is the enzymatic addition of carbohydrate chains to proteins or lipids in cells. Carbohydrate chains vary greatly in composition and length and are often branched. Glycosylation (and deglycosylation) play roles in protein and lipid conformation, interaction, function, and stability.

Fucosidase

Glucosidase

Mannosidase

Other

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules Plymouth Meeting, PA USA1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21