Cell Cycle / Cell Division

  • Abemaciclib | Potent and selective CDK 4/6 inhibitor

    CAS:
    1231930-82-7
    Catalog Number:
    10-4833
    Activity:
    Potent and selective CDK 4/6 inhibitor
    Chemical Name:
    N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyridine-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine methanesulfonic acid salt
    Alternate Name:
    LY2835219 mesylate
    Molecular Weight:
    602.70
    Molecular Formula:
    C27H32F2N8 ∙ CH3SO3H
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to at least 25 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
    From $50.00
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  • Adavosertib | Wee1 kinase inhibitor

    CAS:
    955365-80-7
    Catalog Number:
    10-4823
    Activity:
    Wee1 kinase inhibitor
    Chemical Names:
    1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)-phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo[3,4-d]pyrimidin-3-one
    Alternate Name:
    MK-1775; AZD1775
    Molecular Weight:
    500.61
    Molecular Formula:
    C27H32N8O2
    Solubility:
    Soluble in DMSO (70 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $45.00
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  • Alisertib | Potent and selective inhibitor of Aurora A / Destabilizes Myc

    CAS:
    1028486-01-2
    Catalog Number:
    10-4124
    Activity:
    Potent and selective inhibitor of Aurora A / Destabilizes Myc
    Chemical Name:
    4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid
    Alternate Names:
    MLN8237
    Molecular Weight:
    518.92
    Molecular Formula:
    C27H20ClFN4O4
    Solubility:
    Soluble in DMSO (up to 5 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $60.00
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  • Alsterpaullone | GSK-3ß inhibitor

    CAS:
    237430-03-4
    Catalog Number:
    10-1397
    Activity:
    GSK3β inhibitor, CDK5/p25 inhibitor
    Chemical Name:
    9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one
    Molecular Weight:
    293.28
    Molecular Formula:
    C16H11N3O3
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    Brown solid
    Purity:
    96% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
    From $56.00
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  • AZ3146 | Mps1 kinase inhibitor

    CAS:
    1124329-14-1
    Catalog Number:
    10-4778
    Activity:
    Mps1 kinase inhibitor
    Chemical Name:
    9-Cyclopentyl-2-[2-methoxy-4-(1-methylpiperidine-4-yl)oxyanilino]-7-methylpurin-8-one
    Molecular Weight:
    452.56
    Molecular Formula:
    C24H32N6O3S2
    Solubility:
    Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to at least 25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
    From $60.00
    View Product This product has multiple variants. The options may be chosen on the product page
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