Lipases

Lipases, which occur in various tissue types and cellular organelles, are serine hydrolases—a serine in their catalytic site plays a critical role in hydrolysis of their targets. They act on diacylglycerols, phospholipids, cholesteryl esters, and triacylglycerols, among others. They function in lipid metabolism, inflammation, and cell signaling.

DAG

  • LY2183240 | Anandamide uptake inhibitor
    CAS:
    874902-19-9
    Catalog Number:
    10-2636
    Activity:
    Andamide uptake inhibitor
    Chemical Name:
    5-([1,1′-Biphenyl]-4-ylmethyl)-N,N,-dimethyl-1H-tetrazole-1-carboxamide
    Molecular Weight:
    307.35
    Molecular Formula:
    C17H17N5O
    Solubility:
    Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 15 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO of ethanol may be stored at -20°C for up to 1 month
    Shipping Code:
    RT
  • Orlistat | DAG Lipase-α inhibitor
    CAS:
    96829-58-2
    Catalog Number:
    10-2448
    Activity:
    DAG Lipase-α inhibitor
    Alternate Names:
    Ro18-0647, (-)-Tetrahydrolipstatin
    Chemical Name:
    N-Formyl-L-leucine (1S)-10[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester
    Molecular Weight:
    495.75
    Molecular Formula:
    C29H53NO5
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 50 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
    Shipping Code:
    RT
  • RHC-80267 | DAG Lipase inhibitor
    CAS:
    83654-05-1
    Catalog Number:
    10-1051
    Activity:
    DAG Lipase inhibitor
    Alternate Names:
    U-57908
    Chemical Name:
    1,6-bis(Cyclohexyloximinocarbonyl-amino)hexane
    Molecular Weight:
    394.53
    Molecular Formula:
    C20H34N4O4
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
    Shipping Code:
    RT
View All DAG Products

MAG

  • ABX-1431 | MAGL inhibitor
    CAS:
    1446817-84-0
    Catalog Number:
    10-4596
    Activity:
    Potent and selective inhibitor of MAGL
    Chemical Name:

    1,1,1,3,3,3-Hexafluoropropan-2-yl-4-[[2-(pyrrolidin-1-yl)-4-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate

    Alternate Name:
    Elcubragistat
    Molecular Weight:
    507.40
    Molecular Formula:
    C20H22F9N3O2
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Nonylbenzeneboronic acid | FAAH
    CAS:
    256383-45-6
    Catalog Number:
    10-3277
    Activity:
    FAAH Inhibitor
    Chemical Name:
    4-n-Nonylbenzeneboronic acid
    Alternate Names:
    NBBA
    Molecular Weight:
    248.17
    Molecular Formula:
    C15H25BO2
    Solubility:
    Soluble in DMSO (up to 30 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • LY2183240 | Anandamide uptake inhibitor
    CAS:
    874902-19-9
    Catalog Number:
    10-2636
    Activity:
    Andamide uptake inhibitor
    Chemical Name:
    5-([1,1′-Biphenyl]-4-ylmethyl)-N,N,-dimethyl-1H-tetrazole-1-carboxamide
    Molecular Weight:
    307.35
    Molecular Formula:
    C17H17N5O
    Solubility:
    Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 15 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO of ethanol may be stored at -20°C for up to 1 month
    Shipping Code:
    RT
  • JZL-184 | MAG lipase inhibitor
    CAS:
    1101854-58-3
    Catalog Number:
    10-1021
    Activity:
    MAG lipase inhibitor
    Chemical Name:
    4-Nitrophenyl-4-(dibenzo[d][1,3]dioxol-5-yl(hydroxyl)methyl)piperidine-1-carboxylate
    Molecular Weight:
    520.5
    Molecular Formula:
    C27H24N2O9
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    Light yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
    Shipping Code:
    RT
View All MAG Products

Other Lipases

  • NG-497 | Human ATGL inhibitor
    CAS:
    2598242-66-9
    Catalog Number:
    10-4626
    Activity:
    Human ATGL inhibitor
    Chemical Names:
    Isopropyl 6-(4-ethoxyphenyl)-4-methoxypicolinate
    Molecular Weight:
    315.37
    Molecular Formula:
    C18H21NO4
    Solubility:
    Soluble in DMSO (25 mg/ml with warming); Ethanol (20 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • DO264 | ABHD12 inhibitor
    CAS:
    2301866-59-9
    Catalog Number:
    10-3712
    Activity:
    ABHD12 inhibitor
    Chemical Name:
    1-(1-(3-Chloro-4-(2-chloro-4-(trifluoromethyl)phenoxy)pyridin-2-yl)piperidin-4-yl)-3-(pyridin-3-yl)thiourea
    Molecular Weight:
    542.40
    Molecular Formula:
    C23H20Cl2F3N5OS
    Solubility:
    Soluble in DMSO (up to 30 mg/ml).
    Physical Properties:
    Pale yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Atglistatin | ATGL inhibitor
    CAS:
    1469924-27-3
    Catalog Number:
    10-4598
    Activity:
    ATGL inhibitor
    Chemical Name:
    N’-[4’-(Dimethylamino)[1,1’-biphenyl]-3-yl]-N,N,-dimethylurea
    Molecular Weight:
    283.37
    Molecular Formula:
    C17H21N3O
    Solubility:
    Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 5 mg/ml with warming)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • LY2183240 | Anandamide uptake inhibitor
    CAS:
    874902-19-9
    Catalog Number:
    10-2636
    Activity:
    Andamide uptake inhibitor
    Chemical Name:
    5-([1,1′-Biphenyl]-4-ylmethyl)-N,N,-dimethyl-1H-tetrazole-1-carboxamide
    Molecular Weight:
    307.35
    Molecular Formula:
    C17H17N5O
    Solubility:
    Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 15 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO of ethanol may be stored at -20°C for up to 1 month
    Shipping Code:
    RT
View All Other Lipases Products

Phospholipases

  • Surfactin | Lipopeptide biosurfactant
    CAS:
    24730-31-2
    Catalog Number:
    10-5131
    Activity:
    Lipopeptide biosurfactant
    Source:
    Cyclic peptide produced by Bacillus substilis
    Molecular Weight:
    1036.36 (based on C15 subunit)
    Molecular Formula:
    C53H93N7O13 (based on C15 subunit)
    Solubility:
    Soluble in DMSO (15 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    >98% TLC; HPLC shows mixture of isomers with C14 and C15 side chains predominating.1
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • ONO-RS-082 | Phospholipase A2 inhibitor
    CAS:
    99754-06-0
    Catalog Number:
    10-1107
    Activity:
    Phospholipase A2 Inhibitor
    Chemical Name:
    2-(4-Pentylcinnamoyl)amino-4-chlorobenzoic acid
    Alternate Names:
    PACA
    Molecular Weight:
    371.86
    Molecular Formula:
    C21H22ClNO3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in ethanol (up to 10 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Quinacrine HCl | Antiprotozoan / Anticancer
    CAS:
    69-05-6
    Catalog Number:
    10-4251
    Activity:
    Antiprotozoan / Anticancer
    Chemical Name:
    6-Chloro-9-(4-diethylamino-1-methylbutyl)amino-2-methoxyacridine dihydrochloride
    Molecular Weight:
    472.88
    Molecular Formula:
    C23H30ClN3O • 2HCl
    Solubility:
    Soluble in Water (up to at least 25 mg/ml) or in DMSO (up to at least 10 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. Solutions in water should be made fresh daily.
    Shipping Code:
    RT
  • U-73122 | PLC inhibitor
    CAS:
    112648-68-7
    Catalog Number:
    10-1061
    Activity:
    PLC inhibitor
    Chemical Name:
    1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione
    Molecular Weight:
    464.65
    Molecular Formula:
    C29H40N2O3
    Solubility:
    Very soluble in Methylene chloride or Chloroform. Slightly soluble in DMSO (up to 2 mg/ml) or in Ethanol (up to 1 mg/ml).
    Physical Properties:
    White or off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Use caution when storing DMSO solutions. Typically solutions in DMSO can be stored at -20°C for approximately 2 months. However, any solutions that turn pink should be discarded.
    Shipping Code:
    RT
  • Dihydrosphingosine | PKC inhibitor/Sphingosine precursor
    CAS:
    764-22-7
    Catalog Number:
    10-4492
    Activity:
    PKC inhibitor, Sphingosine precursor
    Alternate Names:
    Sphinganine
    Molecular Weight:
    301.51
    Molecular Formula:
    C18H39NO2
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All Phospholipases Products

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