Phosphatases

Phosphatases are hydrolases that catalyze the cleavage of phosphate groups from proteins, carbohydrates (such as inositol), nucleotides, or lipids. Their substrate selectivity can vary greatly, but they are fundamental to cellular function and signaling

Calcineurin (PP2B)

  • Ascomycin | FKBP ligand/Immunosuppressant
    CAS:
    11011-38-4
    Catalog Number:
    10-2059
    Activity:
    FKBP ligand; immunosuppressant
    Alternate Names:
    FK-520, FR-900520
    Chemical Name:
    Fermentation product from Streptomyces hygroscopicus
    Molecular Weight:
    729.03
    Molecular Formula:
    C43H69NO12
    Solubility:
    Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml with warming).
    Physical Properties:
    White solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Cyclosporin A | Inhibits mitochondrial permeability pore opening
    CAS:
    59865-13-3
    Catalog Number:
    10-1119
    Activity:
    Inhibits mitochondrial permeability pore opening
    Molecular Weight:
    1202.65
    Molecular Formula:
    C62H111N11O12
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    99% by TLC
    Storage Temperature:
    -20°C
    Stability:
    Stable for 3 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • FK-506 | FKBP inhibitor
    CAS:
    104987-11-3
    Catalog Number:
    10-1103
    Activity:
    FKBP inhibitor
    Alternate Names:
    Tacrolimus
    Molecular Weight:
    804.04
    Molecular Formula:
    C44H69NO12
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 50 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All Calcineurin (PP2B) Products

CD45 (PTPRC)

  • (±) RK-682 | Tyrosine phosphatase inhibitor
    CAS:
    154639-24-4
    Catalog Number:
    10-4300
    Activity:
    Tyrosine phosphatase inhibitor
    Chemical Name:
    (±)-3-Hexadecanoyl-5-hydroxymethyltetronic acid
    Molecular Weight:
    368.52
    Molecular Formula:
    C21H36O5
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml).
    Physical Properties:
    Off-white or Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All CD45 (PTPRC) Products

CDC25

  • NSC95397 | CtBP inhibitor; Cdc25 phosphatase inhibitor
    CAS:
    93718-83-3
    Catalog Number:
    10-1565
    Activity:
    CtBP inhibitor; Cdc25 phosphatase inhibitor
    Chemical Name:
    2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone
    Molecular Weight:
    310.39
    Molecular Formula:
    C14H14O4S2
    Solubility:
    Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 1 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • NSC663284 | Cdc25 phosphatase inhibitor
    CAS:
    383907-43-5
    Catalog Number:
    10-1352
    Activity:
    Cdc25 phosphatase inhibitor
    Chemical Name:
    6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione
    Molecular Weight:
    321.77
    Molecular Formula:
    C15H16ClN3O3
    Solubility:
    Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 55 mg/ml).
    Physical Properties:
    Red solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All CDC25 Products

Inositol Phosphatase

  • AS-1949490 | SHIP2 inhibitor
    CAS:
    1203680-76-5
    Catalog Number:
    10-5103
    Activity:
    SHIP2 inhibitor
    Chemical Names:
    3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]- 2-thiophenecarboxamide
    Molecular Weight:
    371.88
    Molecular Formula:
    C20H18ClNO2S
    Solubility:
    Soluble in DMSO (40 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.
    Shipping Code:
    RT
View All Inositol Phosphatase Products

Other Phosphatases

View All Other Phosphatases Products

PP1

  • Microcystin LR | Protein phosphatase PP1 and PP2A inhibitor
    CAS:
    101043-37-2
    Catalog Number:
    10-2719
    Activity:
    Protein phosphatase PP1 and PP2A inhibitor
    Source:
    Isolated from Microcystis aeruginosa, a fresh water cyanobacteria
    Molecular Weight:
    995.17
    Molecular Formula:
    C49H74N10O12
    Solubility:
    Soluble in DMSO, methanol or ethanol
    Physical Properties:
    Off-white lyophilized solid
    Purity:
    95% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Okadaic acid | Protein phosphatase inhibitor
    CAS:
    78111-17-8
    Catalog Number:
    10-2091
    Activity:
    Protein phosphatase inhibitor
    Source:
    Isolated from marine dinoflagellates
    Molecular Weight:
    805.00
    Molecular Formula:
    C44H68O13
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Cantharidin | Phosphatase PP2A inhibitor
    CAS:
    56-25-7
    Catalog Number:
    10-1013
    Activity:
    Phosphatase PP2A inhibitor
    Chemical Name:
    3α,7α-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione
    Molecular Weight:
    196.2
    Molecular Formula:
    C10H12O4
    Solubility:
    Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 weeks.
    Shipping Code:
    RT
View All PP1 Products

PP2A

  • Microcystin LR | Protein phosphatase PP1 and PP2A inhibitor
    CAS:
    101043-37-2
    Catalog Number:
    10-2719
    Activity:
    Protein phosphatase PP1 and PP2A inhibitor
    Source:
    Isolated from Microcystis aeruginosa, a fresh water cyanobacteria
    Molecular Weight:
    995.17
    Molecular Formula:
    C49H74N10O12
    Solubility:
    Soluble in DMSO, methanol or ethanol
    Physical Properties:
    Off-white lyophilized solid
    Purity:
    95% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Okadaic acid | Protein phosphatase inhibitor
    CAS:
    78111-17-8
    Catalog Number:
    10-2091
    Activity:
    Protein phosphatase inhibitor
    Source:
    Isolated from marine dinoflagellates
    Molecular Weight:
    805.00
    Molecular Formula:
    C44H68O13
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Cantharidin | Phosphatase PP2A inhibitor
    CAS:
    56-25-7
    Catalog Number:
    10-1013
    Activity:
    Phosphatase PP2A inhibitor
    Chemical Name:
    3α,7α-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione
    Molecular Weight:
    196.2
    Molecular Formula:
    C10H12O4
    Solubility:
    Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 weeks.
    Shipping Code:
    RT
View All PP2A Products

PTP1B

  • KY-226 | PTP1B inhibitor
    CAS:
    1621673-53-7
    Catalog Number:
    10-4004
    Activity:
    PTP1B Inhibitor
    Chemical Name:
    4-(Biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide
    Molecular Weight:
    481.67
    Molecular Formula:
    C27H31NO3S2
    Solubility:
    Soluble in DMSO (>25 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    >98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All PTP1B Products

SHP

  • SHP099 | SHP2 inhibitor
    CAS:
    1801747-11-4
    Catalog Number:
    10-4604
    Activity:
    SHP2 inhibitor
    Chemical Name:
    6-(4-Amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine dihydrochloride
    Molecular Weight:
    425.18
    Molecular Formula:
    C16H19Cl2N5 • 2HCl
    Solubility:
    Soluble in DMSO (up to 5 mg/ml) or in water (up to at least 20 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All SHP Products

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