Phosphodiesterases

Phosphodiesterases (PDEs) hydrolyze phosphodiester bonds, most often in the cyclic nucleotides cAMP and cGMP. In doing so, they mediate the many signaling pathways that utilize these second messengers. They comprise a family of enzymes expressed in many different tissue types, and are involved in neurological, pulmonary, and vascular diseases, among others.

cAMP-selective

  • Roflumilast | PDE4 inhibitor
    CAS:
    162401-32-3
    Catalog Number:
    10-2657
    Activity:
    PDE4 inhibitor
    Chemical Name:
    3(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-benzamide
    Alternate Names:
    BYK-20869
    Molecular Weight:
    403.21
    Molecular Formula:
    C17H14N2Cl2F2O3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • BRL-50481 | PDE7 inhibitor
    CAS:
    433695-36-4
    Catalog Number:
    10-1300
    Activity:
    PDE7 inhibitor
    Chemical Name:
    3-(N,N-Dimethylsulfonamido)-4-methylnitrobenzene
    Molecular Weight:
    244.27
    Molecular Formula:
    C9H12N2O4
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Rolipram | PDE4 inhibitor
    CAS:
    61413-54-5
    Catalog Number:
    10-1079
    Activity:
    PDE4 inhibitor
    Alternate Names:
    ZK 62711
    Chemical Name:
    4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone (racemic)
    Molecular Weight:
    275.35
    Molecular Formula:
    C16H21NO3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White or off-white solid
    Purity:
    98% by TLC
    NMR conforms
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • RO 20-1724 | PDE4 inhibitor
    CAS:
    29925-17-5
    Catalog Number:
    10-1014
    Activity:
    PDE4 inhibitor
    Chemical Name:
    4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
    Molecular Weight:
    278.35
    Molecular Formula:
    C15H22N2O3
    Solubility:
    Soluble in DMSO (up to 200 mg/ml) or in Ethanol (up to 40 mg/ml).
    Physical Properties:
    White solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.
    Shipping Code:
    RT
View All cAMP-selective Products

cGMP-selective

  • EHNA HCl | PDE2 inhibitor
    CAS:
    51350-19-7
    Catalog Number:
    10-2438
    Activity:
    PDE2 inhibitor
    Chemical Names:
    Erythro-9-(2-hydroxy-3-nonyl)adenine, hydrochloride; NSC 263164
    Molecular Weight:
    318.87
    Molecular Formula:
    C14H28N5O ∙ HCl
    Solubility:
    Soluble in Water (up to 25 mg/ml)
    Physical Properties:
    Pale yellow or off-white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Sildenafil citrate | PDE5 inhibitor
    CAS:
    171599-83-0
    Catalog Number:
    10-1221
    Activity:
    PDE5 inhibitor
    Chemical Names:
    1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate; UK-92480
    Molecular Weight:
    666.70
    Molecular Formula:
    C22H30N6O4S • C6H8O7
    Solubility:
    Soluble in DMSO (up to 60 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Sulindac Sulfide | NFkappaB inhibitor
    CAS:
    49627-27-2
    Catalog Number:
    10-2156
    Activity:
    NFkappaB inhibitor
    Chemical Name:
    (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid
    Molecular Weight:
    340.42
    Molecular Formula:
    C20H17FO2S
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Sulindac Sulfone | Modulates beta-catenin-mediated effects
    CAS:
    59864-04-9
    Catalog Number:
    10-1122
    Activity:
    Modulates beta-catenin-mediated effects
    Chemical Name:
    (Z)-5-Fluoro-2-methyl-1-[p-(methylsulfonyl)benzylidene]indene-3-acetic acid
    Molecular Weight:
    372.41
    Molecular Formula:
    C20H17FO4S
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    >98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
    Shipping Code:
    RT
View All cGMP-selective Products

Dual

  • Anagrelide HCl | PDE3 inhibitor
    CAS:
    58579-51-4
    Catalog Number:
    10-1220
    Activity:
    PDE3 inhibitor
    Chemical Name:
    6,7-dichloro-1,5-dihydroimidazo[2,1 –b]quinazolin-2(3H)-one hydrochloride
    Alternate Names:
    BL-4162A
    Molecular Weight:
    292.55
    Molecular Formula:
    C10H7Cl2N3O • HCl
    Solubility:
    Soluble in DMSO (up to 2.5 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • BML-288 | PDE2 inhibitor
    CAS:
    851-55-3
    Catalog Number:
    10-1319
    Activity:
    PDE2 inhibitor
    Chemical Name:
    6,7-Dihydro-5-methyl-6-oxo-N-(1,3,4-thiadiazol-2-yl)-5H-furo[2,3-f]indole-7-carboxamide
    Molecular Weight:
    314.32
    Molecular Formula:
    C14H10N4O3S
    Solubility:
    Soluble in DMSO (up to 25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Dipyridamole | Pan-specific PDE inhibitor
    CAS:
    58-32-2
    Catalog Number:
    10-1095
    Activity:
    Pan-specific PDE inhibitor
    Chemical Name:
    2,6-bis(Diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
    Alternate Names:
    NSC-515776
    Molecular Weight:
    504.63
    Molecular Formula:
    C24H40N8O4
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 5 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Ibudilast | Neuroinflammation inhibitor
    CAS:
    50847-11-5
    Catalog Number:
    10-2236
    Activity:
    Neuroinflammation inhibitor
    Chemical Name:
    3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine
    Alternate Names:
    2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridine-3-yl 1-propanone; KC-404; AV411
    Molecular Weight:
    230.31
    Molecular Formula:
    C14H18N2O
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or Ethanol (up to 20 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Vinpocetine | PDE1 inhibitor
    CAS:
    42971-09-5
    Catalog Number:
    10-1126
    Activity:
    PDE1 inhibitor
    Chemical Name:
    (3α,16α)-Eburnamenine-14-carboxylic acid ethyl ester
    Molecular Weight:
    350.45
    Molecular Formula:
    C22H26N2O2
    Solubility:
    Soluble in DMSO (up to 5 mg/ml), in ethanol (up to 15 mg/ml) or in DMF (up to 3 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO, Ethanol, or DMF may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Dual Products

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