my account
Login
  Loading... Please wait...

DNA

Sort by
  • 2'-Deoxy-5-fluorocytidine | Irreversible DNA methyl transferase inhibitor
    $52.00
    2'-Deoxy-5-fluorocytidine (10356-76-0) is a DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors1. Like 5'-Azacytidine (Cat.# 10-1267) and decitabine (Cat.# 10-2412),...

  • 4-HQN | 491-36-1 | Structure | Supplier
    $30.00
    4-HQN (491-36-1) is an inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 = 9.5 μM).1 Displays mixed inhibition with respect to NAD+. Protective against ischemia-reperfusion induced ROS production, and subsequent...

  • 6-Thioguanine | Anticancer agent / Downregulates DNMT1
    $30.00
    6-Thioguanine (154-42-7) is a methyltransferase inhibitor.  After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It...

  • 8-Oxo-2'-deoxyguanosine | Marker for DNA damage
    $38.00
    8-Oxo-2'-deoxyguanosine (88847-89-6) is a useful marker for DNA damage via a variety of oxidative processes1. It is a critical biomarker for oxidative stress and carcinogenesis2,3. References/Citations1) Beckman et al...

  • Bleomycin sulfate | Fibrosis-inducing agent
    $90.00
    Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Commonly used to induce lung fibrosis in animal disease models.3,4 Anticancer agent in...

  • Cisplatin | Anticancer agent
    $50.00
    Induces intra- and interstrand DNA adducts which poison topoisomerase I.1 Synergizes with topoisomerase I inhibitors such as topotecan.1 Induces apoptosis by sequential activation of caspase-8, -3 and -6 in osteosarcoma...

  • Epirubicin HCl | DNA damaging agent
    $85.00
    Epirubicin HCl (56390-09-1) is an antitumor agent1. Inhibits topoisomerase II2. Induces DNA damage by a number of different mechanisms including intercalation, free radical-mediated oxidation, crosslinking, interference with...

  • Gemcitabine HCl | DNA polymerase inhibitor
    $30.00
    Gemcitabine HCl (122111-03-9) is a clinically useful anticancer agent.1 It exerts its cytotoxic effects via the metabolites gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP). dFdCTP is an inhibitor of...

  • Herboxidiene | 142861-00-5 | Structure | Supplier
    $80.00
    Herboxidiene (142861-00-5) is a novel polyketide fermentation product produced by Streptomyces chromofuscus, originally discovered by screening for herbicidal activity. Potent and selective inhibitor of spliceosome subunit...

  • Iniparib | PARP inhibitor
    $65.00
    Iniparib (160003-66-7) was originally thought to be a PARP1 inhibitor but this is controversial.1,2 Inhibits ionizing radiation-induced single-stranded DNA break repair in lymphoid cell lines in vivo.3 Inhibits growth of...

  • Irinotecan HCl | Topoisomerase I inhibitor
    $99.00
    Irinotecan (136572-09-3) is a semi-synthetic derivative of camptothecin (Cat.# 10-1041) that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38,...

  • Mitomycin C | 50-07-7 | Structure | Supplier
    $32.00
    Mitomycin C (50-07-7) is a DNA damaging and crosslinking agent. Induces apoptosis in various cell lines. Cell permeable. This product is not approved for human therapeutic use. References/Citations1) Tee and Proud (2000),...

  • Olaparib | PARP1 inhibitor
    $40.00
    Olaparib (763113-22-0) is a highly potent and selective PARP-inhibitor with IC50 values of 5 nM and 1 nM for PARP-1 and PARP-2, respectively.1  In a genetically engineered mouse model for BRCA1-associated breast cancer...

  • RI-1 | RAD51 inhibitor
    $58.00
    RI-1 (415713-60-9) is a potent and selective inhibitor of RAD51 (IC50 = 5-30 mM), a highly conserved protein that catalyzes DNA repair via homologous recombination.1 It specifically reduces gene conversion in human cells and...

  • SN-38 | DNA topoisomerase I inhibitor
    $75.00
    SN-38 (86639-52-3) is the active metabolite of CPT-11 that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1...

  • Temozolomide | Autophagy inducer
    $75.00
    Temozolomide (85622-93-1) is a DNA alkylating agent with antitumor and antiangiogenic activity1,2. Clinically useful anticancer agent3. Temozolomide induces autophagy in a variety of cell lines4. Cell permeable...

Share Focus

Connect with Focus