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DNA Damage

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  • 5-Fluorouracil | 51-21-8 | Structure | Supplier
    $20.00
    5-Fluorouracil (51-21-8) is a clinically useful anticancer agent that acts via irreversible inhibition of thymidylate synthase. The active metabolites of 5-Fluorouracil are 5-Fluorodeoxyuridylate (5-FdUMP),...

  • 8-Oxo-2'-deoxyguanosine | Marker for DNA damage
    $38.00
    8-Oxo-2'-deoxyguanosine (88847-89-6) is a useful marker for DNA damage via a variety of oxidative processes1. It is a critical biomarker for oxidative stress and carcinogenesis2,3. References/Citations1) Beckman et al...

  • BML-277 | 516480-79-8 | Structure | Supplier
    $90.00
    BML-277 (516480-79-8) is a potent selective inhibitor of Chk2 (IC50 = 15 nM). BML-277 has been screened against a panel of 35 kinases, and shows less that 25% inhibition of any other kinase at 10 μM, demonstrating the...

  • Camptothecin | 7689-03-4 | Structure | Supplier
    $55.00
    Camptothecin (7689-03-4) is a natural product isolated from the Chinese Happy Tree, Camptotheca acuminate. It is an inhibitor of DNA topoisomerase I. Camptothecin binds irreversibly to the topoisomerase I /DNA complex...

  • Doxorubicin HCl | DNA damaging agent
    $70.00
    Doxorubicin HCl (25316-40-9) is an antitumor antibiotic. Induces DNA damage by intercalation1 and inhibition of topoisomerase II. Doxorubicin HCl induces apoptosis in a variety of cell lines2. Acts as a substrate for MDR13...

  • Epirubicin HCl | DNA damaging agent
    $85.00
    Epirubicin HCl (56390-09-1) is an antitumor agent1. Inhibits topoisomerase II2. Induces DNA damage by a number of different mechanisms including intercalation, free radical-mediated oxidation, crosslinking, interference with...

  • Etoposide | 33419-42-0 | Structure | Supplier
    $68.00
    Etoposide (33419-42-0) is a chemotherapeutic agent that forms a ternary complex with DNA and topoisomerase II, preventing re-ligation of DNA strands causing DNA cleavage. Etoposide blocks the cell cycle in S-phase and...

  • Fascaplysin | 114718-57-2 | Structure | Supplier
    $40.00
    Fascaplysin (114719-57-2) is a novel marine natural product isolated from Thorectandra sp.1 A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50 = 0.35 μM) and is less selective for Cdk6/D1...

  • GPI-16552 | 443794-40-9 | Structure | Supplier
    $60.00
    GPI-16552 (443794-40-9) is a novel potent inhibitor of poly(ADP-ribose) glycohydrolase (PARG), IC50=1.7 μM1. Pre or post ischemia treatment (40 mg/kg) with GPI-16552 reduces brain infarct volumes in a rat model of...

  • Irinotecan HCl | Topoisomerase I inhibitor
    $99.00
    Irinotecan (136572-09-3) is a semi-synthetic derivative of camptothecin (Cat.# 10-1041) that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38,...

  • ME-0328 | 1445251-22-8 | Structure | Supplier
    $75.00
    ME-0328 (1445251-22-8) is a potent and selective PARP3 inhibitor (IC50=0.89 μM). Selective over PARP-1, PARP-2 and other ARDT enzymes (IC50=6.3, 10.8 and >30 μM respectively) References/Citations1) Lindgren et al...

  • Mirin | 299953-00-7 | Structure | Supplier
    $50.00
    Mirin (299953-00-7) is an inhibitor of the Mre11-Rad50-Nbs1(MRN) complex (IC50 = 12 μM for inhibition of ATM activity), part of the MRN-ATM(ataxia-telangiectasia mutated) pathway, an essential pathway for sensing and...

  • Mitomycin C | 50-07-7 | Structure | Supplier
    $32.00
    Mitomycin C (50-07-7) is a DNA damaging and crosslinking agent. Induces apoptosis in various cell lines. Cell permeable. This product is not approved for human therapeutic use. References/Citations1) Tee and Proud (2000),...

  • PJ-34 HCl | PARP1,2 inhibitor
    $65.00
    PJ-34 HCl (344458-15-7) is a potent and selective inhibitor of PARP1 and 2. EC50 = 20 nM1. Reduces ischemia reperfusion injury in a mouse model.2 Displays anti-inflammatory effects in a transient focal cerebral ischemia...

  • SN-38 | DNA topoisomerase I inhibitor
    $75.00
    SN-38 (86639-52-3) is the active metabolite of CPT-11 that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1...

  • Temozolomide | Autophagy inducer
    $75.00
    Temozolomide (85622-93-1) is a DNA alkylating agent with antitumor and antiangiogenic activity1,2. Clinically useful anticancer agent3. Temozolomide induces autophagy in a variety of cell lines4. Cell permeable...

  • YM-155 | 781661-94-7 | Structure | Supplier
    $58.00
    YM-155 (781661-94-7) is a novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on...

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