Cellular Metabolism

AUTOPHAGY

Ion & Other Channels

Epigenetics

Cytoskeleton

Kinases

Mitochondria

Nuclear Receptors

Bioactive Lipids

Ubiquitin Proteasome

VIEW ALL Biochemical Targets

The cytoskeleton is the structure that maintains a cell’s shape, internal organization, and provides support for essential cellular functions such as movement and division. It spans the cytoplasm and connects the cell nucleus with the extracellular matrix. Three main types of filamentous proteins comprise the cytoskeleton in eukaryotes: Microtubules (tubulin polymer) are the largest filament and are involved in maintaining the structure of the cell, cell division, providing a platform for intracellular transport, and moving various organelles and vesicles. Actin filaments are the smallest and are involved in specialized cell shapes, cytokinesis, and cell movement. There are several types of intermediate filaments (i.e. desmin, lamin, vimentin) but all are strong and involved in mechanical support of cellular structures. Pathologies related to cytoskeletal protein dysfunction include cancer, neurodegeneration, cardiovascular disease, pulmonary fibrosis and cirrhosis.

Microtubules

Ansamitocin P3

Ansamitocin causes extensive disassembly of microtubules

Epothilone B

Epothilone B induces microtubule polymerization

Nocodazole

Disrupts microtubules by binding to β tubulin and inhibiting microtubule dynamics

Kinesin

K858

K858 is a selective mitotic kinesin Eg5 inhibitor

Monastrol

Monastrol is an inhibitor of the mitotic kinesin Eg5

Actin

Latrunculin A

Lat A inhibits actin polymerization and disrupts microfilament organization

Cytochalasin D

Cytochalasin D is a potent inhibitor of actin polymerization

Mycalolide B

Completely depolymerizes G-actin via a different mechanism than Cytochalasin D

Cytoskeleton

New Products

BIOCHEMICAL TARGETS

Processes and Diseases

CUSTOM SYNTHESIS

CHEMICAL LIBRARIES

FOCUS NEWS:

Update on the Latest Anti-SARS-CoV-2 Molecules

The emergence of SARS-CoV-2 has precipitated an unprecedented effort by the scientific community to find and develop potential therapeutics and vaccines for this new virus to halt the ongoing pandemic’s onslaught. Fortunately, the SARS-CoV-2 genome is highly...

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

®Copyright 2020 Focus Biomolecules. All Rights Reserved. Site by A.N. Creative