Angiogenesis

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Cytokines

SX-682 | CXCR1/2 inhibitor

CAS:

1648843-04-2

Catalog Number:

10-4925

Activity:

CXCR1/2 inhibitor

Chemical Names:

[2-[[5-[(4-Fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid

Molecular Weight:

467.20

Molecular Formula:

C₁₉H₁₄BF₄N₃O₄S

Solubility:

Soluble in DMSO (>25 mg/ml)

Physical Properties:

Off-white solid

Purity:

>98% HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

AZD-2098 | CCR4 antagonist

CAS:

566203-88-1

Catalog Number:

10-4262

Activity:

CCR4 antagonist

Chemical Names:

2,3-Dichloro-N-(3-methoxypyrazine-2-yl)benzenesulfonamide

Molecular Weight:

334.17

Molecular Formula:

C₁₁H₉Cl₂N₃O₃S

Solubility:

Soluble in DMSO (>25 mg/ml)

Physical Properties:

Off-white/beige solid

Purity:

>98% HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

PF-4136309 | CCR2 antagonist

CAS:

1341224-83-6

Catalog Number:

10-4261

Activity:

CCR2 antagonist

Chemical Name:

N-[2-[(3S)-3-[[4-Hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-2-oxoethyl]-3-(trifluoromethyl)benzamide

Alternate Name:

INCB8761

Molecular Weight:

568.60

Molecular Formula:

C₂₉H₃₁F₃N₆O₃

Solubility:

Soluble in DMSO (up to at least 25 mg/ml)

Physical Properties:

Off-white solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

DLL4/Notch

CB-103 | Notch signaling pathway inhibitor

CAS:

218457-67-1

Catalog Number:

10-4742

Activity:

Notch inhibitor

Chemical Names:

5-Amino-2-(4-tert-butylphenoxy)pyridine

Molecular Weight:

242.32

Molecular Formula:

C₁₅H₁₈N₂O

Solubility:

Soluble in DMSO (>30 mg/ml)

Physical Properties:

Off-white to pale orange solid

Purity:

>98% HPLC
NMR (Conforms)

Storage Temperature:

Room temperature

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

IMR-1 | Notch transcriptional activation inhibitor

CAS:

310456-65-6

Catalog Number:

10-3601

Activity:

Notch transcriptional activation inhibitor

Chemical Name:

2-[2-Methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid ethyl ester

Molecular Weight:

353.41

Molecular Formula:

C₁₅H₁₅NO₅S₂

Solubility:

Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 9 mg/ml with warming).

Physical Properties:

Yellow solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

Shipping Code:

FLI-06 | Notch pathway inhibitor

CAS:

313967-18-9

Catalog Number:

10-1504

Activity:

Notch pathway inhibitor

Molecular Weight:

438.52

Molecular Formula:

C₂₅H₃₀N₂O₅

Solubility:

Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml).

Physical Properties:

Yellow solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.

Shipping Code:

Ephrin

Sitravatinib | Multikinase inhibitor / Immuno-oncology agent

CAS:

1123837-84-2

Catalog Number:

10-4826

Activity:

Multikinase inhibitor / Immuno-oncology agent

Chemical Name:

1-N’-[3-Fluoro-4-[2-[5-[(2-methoxyethylamino)methyl]pyridin-2-yl]thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Alternate Names:

MGCD516

Molecular Weight:

629.68

Molecular Formula:

C₃₃H₂₉N₅O₄S

Solubility:

Soluble in DMSO (up to at least 25 mg/ml), or in Ethanol (up to at least 25 mg/ml)

Physical Properties:

Off-white solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Shipping Code:

Growth factors

Nintedanib | VEGFR, PDGFR, and FGFR kinase inhibitor

CAS:

656247-17-5

Catalog Number:

10-3320

Vandetanib | VEGFR2 inhibitor

CAS:

443913-73-3

Catalog Number:

10-2185

Activity:

VEGFR2 inhibitor

Chemical Names:

4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-yl)methoxy]quinazoline

Alternate Name:

ZD6474

Molecular Weight:

475.35

Molecular Formula:

C₂₂H₂₄BrFN₄O₂

Solubility:

Soluble in DMSO (30 mg/ml); Ethanol (10 mg/ml with warming)

Physical Properties:

White to off-white solid

Purity:

98% TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Shipping Code:

Lenvatinib | VEGFR inhibitor

CAS:

417716-92-8

Catalog Number:

10-3313

Activity:

VEGFR inhibitor

Chemical Name:

4-[3-Chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-6-quinolinecarboxamide

Alternate Names:

E7080

Molecular Weight:

426.85

Molecular Formula:

C₂₁H₁₉ClN₄O₄

Solubility:

Soluble in DMSO (up to 20 mg/ml)

Physical Properties:

White solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

HIF

Roxadustat | Proyl hydroxylase domain inhibitor / HIF stabilizer

CAS:

808118-40-3

Catalog Number:

10-4468

Activity:

Proyl hydroxylase domain inhibitor / HIF stabilizer

Chemical Name:

2-[(4-Hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid

Alternate Name:

FG-4592

Molecular Weight:

352.35

Molecular Formula:

C₁₉H₁₆N₂O₅

Solubility:

Soluble in DMSO (up to at least 25 mg/ml).

Physical Properties:

Off-white or white solid

Purity:

99% by HPLC

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Shipping Code:

BAY 87-2243 | HIF-1 / Mitochondrial complex I inhibitor

CAS:

1227158-85-1

Catalog Number:

10-4910

Activity:

HIF-1 / Mitochondrial complex I inhibitor

Chemical Name:

5-[1-[[2-(4-Cyclopropylpiperazin-1-yl)pyridin-4-yl]methyl]-5-methylpyrazol-3-yl]-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole

Molecular Weight:

525.54

Molecular Formula:

C₂₆H₂₆F₃N₇O₂

Solubility:

Soluble in DMSO (up to 25 mg/ml) or in Ethanol (10 mg/ml).

Physical Properties:

White solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

Shipping Code:

KC7F2 | HIF-1α inhibitor

CAS:

927822-86-4

Catalog Number:

10-4714

Activity:

HIF-1alpha inhibitor

Chemical Name:

N,N’-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide

Molecular Weight:

570.38

Molecular Formula:

C₁₆H₁₆Cl₄N₂O₄S₄

Solubility:

Soluble in DMSO (up to at least 25 mg/ml)

Physical Properties:

Off-white solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Shipping Code:

ICAMs

Integrins

C19-9 | non-RGD integrin αvß3 receptor inhibitor

CAS:

1477482-47-5

Catalog Number:

10-3977

MetAP2

Fumagillin | MetAP-2 inhibitor

CAS:

23110-15-8

Catalog Number:

10-1146

Activity:

MetAP-2 inhibitor

Chemical Name:

(2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] 2,4,6,8-decatetraenedioic acid ester

Molecular Weight:

458.54

Molecular Formula:

C₂₆H_34>/sub>O7

Solubility:

Soluble in DMSO (up to 25 mg/ml).

Physical Properties:

Orange solid

Purity:

95% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

METALLOPROTEASES

Doxycycline monohydrate | Broad spectrum antibiotic

CAS:

17086-28-1

Catalog Number:

10-3765

Batimastat | Matrix metalloprotease inhibitor (pan-specific)

CAS:

130370-60-4

Catalog Number:

10-1589

Activity:

Matrix metalloproteinase inhibitor (pan-specific)

Chemical Name:

(2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamine)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide

Alternate Names:

BB-94

Molecular Weight:

477.64

Molecular Formula:

C₂₃H₃₁N₃O₄S₂

Solubility:

Soluble in DMSO (up to 45 mg/ml)

Physical Properties:

White solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Shipping Code:

1,10-Phenanthroline HCl | Zn metalloprotease inhibitor

CAS:

18851-33-7

Catalog Number:

10-3017

Activity:

Zn metalloprotease inhibitor

Alternate Names:

o-Phenanthroline hydrochloride hydrate

Molecular Weight:

234.68

Molecular Formula:

C₁₃H₈N₂ • HCl &bul; H₂O

Solubility:

Soluble in DMSO (up to 5 mg/ml) or in Water (up to 2 mg/ml)

Physical Properties:

White solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 2 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.

Shipping Code:

Nitric oxide

Carboxy-PTIO Potassium Salt | Nitric oxide scavenger

CAS:

148819-94-7

Catalog Number:

10-3037

Activity:

Nitric oxide scavenger

Chemical Names:

2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, potassium salt

Molecular Weight:

315.39

Molecular Formula:

C₁₄H₁₆KN₂O₄

Solubility:

Soluble in Water (up to 100 mg/ml) or in DMSO (up to 50 mg/ml)

Physical Properties:

Blue solid

Purity:

98% HPLC
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.

Shipping Code:

DEA NONOate | NO Donor

CAS:

372965-00-9

Catalog Number:

10-4547

Activity:

NO Donor

Chemical Name:

2-(N,N-Diethylamino)-diazenolate-2-oxide diethylammonium salt

Molecular Weight:

206.29

Molecular Formula:

C₄H₁₀N₃O₂ • C₄H₁₂N

Solubility:

Soluble in Water or Ethanol

Physical Properties:

Off-white solid

Purity:

97% by NMR
(¹H-NMR)

Storage Temperature:

-80°C

Stability:

Stable for 1 year from date of purchase s supplied. Protect from exposure to air or moisture. Solutions are not stable and must be prepared immediately before use. See the product description for information on half-life in solution.

Shipping Code:

Blue Ice

Spermine NONOate | NO Donor

CAS:

136587-13-8

Catalog Number:

10-4549

Activity:

NO Donor

Chemical Name:

1-{N-[3-Aminopropyl]-N-[4-(3-aminopropylammonio)butyl]-amino}-diazen-1-ium-1,2-diolate

Molecular Weight:

262.35

Molecular Formula:

C₁₀H₂₆N₆O₂

Solubility:

Soluble in Water or Ethanol

Physical Properties:

Off-white solid

Purity:

97% by (¹H-NMR)

Storage Temperature:

-80°C

Stability:

Stable for 1 year from date of purchase as supplied. Protect from exposure to air or moisture. Buffer solutions are not stable and must be prepared immediately before use.

Shipping Code:

Blue Ice

Plasminogen

Tie-2

YAP/TAZ

PY-60 | YAP Activator

CAS:

2765218-56-0

Catalog Number:

10-3924

Verteporfen | YAP Inhibitor

CAS:

129497-78-5

Catalog Number:

10-3487

Activity:

YAP inhibitor

Chemical Names:

(4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester

Alternate Name:

CL 318,952; BPD-MA

Molecular Weight:

718.79

Molecular Formula:

C₄₁H₄₂N₄O₈

Solubility:

Soluble in DMSO (up to 14 mg/ml)

Physical Properties:

Black solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Other Angiogenesis

Muscone | Cardioprotective and neuroprotective agent

CAS:

541-91-3

Catalog Number:

10-2757

Halofuginone HBr | Prolyl-tRNA synthetase inhibitor

CAS:

64924-67-0

Catalog Number:

10-2381

FAK inhibitor 14 | FAK inhibitor

CAS:

4506-66-5

Catalog Number:

10-2547

Activity:

FAK inhibitor

Alternate Names:

Y15

Chemical Name:

1,2,4,5-Benzenetetramine tetrahydrochloride

Molecular Weight:

284.02

Molecular Formula:

C₆H₁₀N₄ 4HCl

Solubility:

Soluble in DMSO (up to 20 mg/ml) or in Water (up to 15 mg/ml).

Physical Properties:

Grey solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.

Shipping Code:

Angiogenesis

Cytokines

DLL4/Notch

Ephrin

Growth factors

HIF

ICAMs

Integrins

MetAP2

METALLOPROTEASES

Nitric oxide

Plasminogen

Tie-2

YAP/TAZ

Other Angiogenesis

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