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  • 1,10-Phenanthroline HCl | Zn metalloprotease inhibitor
    1,10-Phenanthroline (18851-33-7) is a high affinity chelator of divalent metal ions and may be used to inhibit zinc metalloenzymes.1  It is a potent inhibitor of JAMM-type isopeptidases (DUBs) acting via chelation of an...

  • Focus Biomolecules cell signaling reagent supplier, structure of Aclacinomycin A | Proteasome inhibitor | CAS 57576-44-0
    Aclacinomycin A HCl (75443-99-1) is a specific inhibitor of the 20S proteasome chymotrypsin-like activity.1 Inhibition of Brg1 proteasomal degradation by aclacinomycin A reverses (0.25 μM in ILU-18 cells ) the removal of...

  • Actinonin | Leucyl aminopeptidase inhibitor
    Actinonin (13434-13-4) is a potent hydroxamic acid inhibitor of aminopeptidases which displays analgesic effects by inhibiting enkephalin-degrading enzymes.1 Actinonin also inhibits peptide deformylase.2 Induces...

  • AEBSF HCl | 30827-99-7 | Structure | Supplier
    Irreversible inhibitor of serine proteases including trypsin, chymotrypsin, plasmin, plasma kallikrein and thrombin. Stable, non-toxic and water-soluble alternative to PMSF.1 Typical working concentrations are 0.1-1...

  • ALLN | Calpain inhibitor
    ALLN (110044-82-1) is a cell-permeable, peptide aldehyde inhibitor of calpain I (Ki=190 nM), calpain II (Ki=150 nM), cathepsin L (Ki=0.5 nM) and other neutral cysteine proteases.1 Inhibits cell cycle progression at G1/S and...

  • Antipain 2HCl | Serine and cysteine protease inhibitor
    Serine/cysteine protease inhibitor. Also inhibits some trypsin-like proteases.1 May be used as an additive to prevent proteolytic activity during recombinant protein production in Sf-9 insect cell cultures.2 May be employed...

  • Argatroban | Thrombin inhibitor
    Argatroban (74863-84-6) is a potent and selective inhibitor of thrombin (Ki = 19 nM)1. Prevents platelet-rich arterial thrombosis in a rabbit model2. Ameliorates early brain injury and improves neurological outcomes after...

  • Batimastat | 130370-60-4 | Structure | Supplier
    Batimastat (130370-60-4) is a potent, broad spectrum MMP inhibitor (IC50 =3, 4, 4, 6 and 20 nM for MMPs -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human...

  • Focus Biomolecules cell signaling reagent supplier, structure of Bestatin HCl | Aminopeptidase inhibitor | CAS 65391-42-6
    Bestatin HCl (65391-42-6) inhibits leucine aminopeptidase and aminopeptidases B and N. Inhibits leukotriene A4 hydrolase. Displays immunostimulant activity via activation of macrophages and T lymphocytes. Displays antitumor...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Bromo-PTC | Cruzain inhibitor | CAS 443144-54-5
    Bromo-PTC is a potent inhibitor of cruzain (IC50 = 100 nM). Cruzain is the major cysteine protease of Trypanosoma cruzi, the protozoan parasite responsible for American trypanosomiasis or Chagas' disease. Cruzain is...

  • Bz-Val-Gly-Arg-AMC | Proteasome substrate
    Bz-VGR-AMC (87779-49-5) may be used for measuring the trypsin-like activity of the 20S proteasome, in combination with Suc-LLVY-AMC (Cat.# 10-2971, for assaying its chymotrypsin-like activity) and Z-LLE-AMC, (for determining...

  • Captopril | Angiotensin-converting enzyme inhibitor
    Captopril (62571-86-2) is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.022 μM).1 Also inhibits the bifunctional Zn2+-containing leukotriene A4 hydrolase/aminopeptidase (LTA4 hydrolase) reversibly and...

  • Focus Biomolecules supplier, chemical structure of Carfilzomib | Proteasome inhibitor | CAS 868540-17-4
    Carfilzomib (868540-17-4) is a potent and irreversible proteasome inhibitor.1 Synthetic analog of the microbial product epoxomcin.2 Compared to bortezomib it displays equal potency but greater selectivity for the...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Celastrol | Proteasome inhibitor | CAS 34157-83-0
    Celastrol (34157-83-0) displays potent antioxidant and anti-inflammatory activity. Inhibits NFkB (IC50=270 nM).  It induces heat shock response and cytoprotection in various cells. Inhibits 20S proteasome chymotrypsin...

  • Chymostatin | Inhibitor of Chymotrypsin-like serine proteases
    Chymostatin (9076-44-2) is a potent, competitive, slow-binding inhibitor of a-, b-, g-, d-chymotrypsin, papain and cathepsins B/G (chymotryptase-like serine proteases)1, Ki=9.36 and 13.1 nM for chymotrypsin and chymase2...

  • Cilastatin Na | Protease inhibitor
    Cilastatin Na (81129-83-1) is a dehydropeptidase-1 inhibitor. Inhibits the proteolytic conversion of leukotriene D4 to E4.1  Inhibits the mammalian β-lactamase renal dipeptidase (dehydropeptidase-1, DPEP1) and thus...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CL-82198 | MMP-13 inhibitor | CAS 307002-71-7
    CL-82198 (307002-71-7) is a selective inhibitor of MMP-13 (IC50 = 10 μM). It displayed no activity against MMP-1, MMP-9 or TACE. References/Citations1) Chen, et al. (2000), Structure-based design of a novel, potent, and...

  • DAPT | gamma-secretase inhibitor
    DAPT (208255-80-5)is an inhibitor of γ-secretase (IC50 in human primary neurons = 115 nM for total Aβ or 200 nM for Aβ42 specifically)1. Oral administration of DAPT has been shown to reduce levels of Aβ...

  • E-64 |  66701-25-5 | Structure | Supplier
    E-64 (66701-25-5) is a cell-permeable, epoxysuccinyl peptide irreversible inhibitor of calpain and other cysteine proteases.1,2 Inhibits calpain-dependent apoptosis pathway in T cells3 but promotes heat-induced apoptosis in...

  • Elastatinal | Elastase inhibitor
    Elastatinal (51798-45-9) is an irreversible inhibitor of neutrophil elastase.1 Inhibits rat microglia elastase.2 Inhibits the protease activity of poliovirus and rhinovirus 2A proteinase.3 Inhibits the α...

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