STING

The presence of cytosolic DNA (which can result from viral or bacterial infection) is detected by cyclic GMP-AMP Synthase (cGAS). Their binding activates cGAS, generating the cyclic dinucleotide cGAMP; this in turn causes Stimulator of Interferon Genes (STING) to activate a signaling cascade resulting in interferon release and autophagy and lysosome-dependent cell death. The presence of endogenous DNA (e.g. from cellular stress) can also activate the pathway, leading to inflammation and autoimmune attack.

Agonists

  • MSA-2 | STING agonist
    CAS:
    129425-81-6
    Catalog Number:
    10-4141
  • GNS561 | PPT1 inhibitor/STING activator
    CAS:
    1914148-73-4
    Catalog Number:
    10-4138
  • NVS-STG2 | Molecular glue STING agonist
    CAS:
    3030588-01-0
    Catalog Number:
    10-4134
  • SR-717 | STING agonist
    CAS:
    2375421-09-1
    Catalog Number:
    10-4850
    Activity:
    STING agonist
    Chemical Names:
    Lithium 2-(6-(1H-Imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate
    Molecular Weight:
    381.27
    Molecular Formula:
    C15H8F2N5O3·Li
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month1.
    Shipping Code:
    RT
  • 2′,3′-cGAMP | Endogenous STING agonist
    CAS:
    1441190-66-4
    Catalog Number:
    10-1639
    Activity:
    Endogenous STING agonist
    Chemical Name:
    Adenylyl-(3’5’)-2’guanylic acid, cyclic nucleotide, disodium salt
    Alternate Name:
    2′,3’cyclic GMP-AMP
    Molecular Weight:
    718.38
    Molecular Formula:
    C20H22N10O13P2·2Na
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to 10 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
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Antagonists

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cGAS

  • RU.521 | cGAS Inhibitor
    CAS:
    2262452-06-0
    Catalog Number:
    10-4140
    Activity:
    cGAS Inhibitor
    Chemical Name:

    3-[1-(6,7-Dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methylpyrazol-4-yl]-3H-isobenzofuran-1-one

    Molecular Weight:
    415.23
    Molecular Formula:
    C19H12Cl2N4O3
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white to pale pink solid
    Purity:
    >98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
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