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Immuno-oncology

  • Abemaciclib | Potent and selective CDK 4/6 inhibitor

    CAS:
    1231930-82-7
    Catalog Number:
    10-4833
    Activity:
    Potent and selective CDK 4/6 inhibitor
    Chemical Name:
    N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyridine-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine methanesulfonic acid salt
    Alternate Name:
    LY2835219 mesylate
    Molecular Weight:
    602.70
    Molecular Formula:
    C27H32F2N8 ∙ CH3SO3H
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to at least 25 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
    From $50.00
    View Product This product has multiple variants. The options may be chosen on the product page

  • Acalabrutinib | Highly selective BTK inhibitor

    CAS:
    1420477-60-6
    Catalog Number:
    10-4806
    Alternate Name:
    ACP-196
    Activity:
    Highly selective BTK inhibitor
    Chemical Name:
    4-[8-Amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamide
    Molecular Weight:
    465.52
    Molecular Formula:
    C26H23N7O2
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)

     

    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $45.00
    View Product This product has multiple variants. The options may be chosen on the product page

  • Apilimod | IL-12 and 23/PIKfyve inhibitor

    CAS:
    541550-19-0
    Catalog Number:
    10-4970
    Activity:
    IL-12 and 23/PIKfyve inhibitor
    Chemical Names:
    N-[(E)-(3-Methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine; STA5326
    Molecular Weight:
    418.50
    Molecular Formula:
    C23H26N6O2
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $35.00
    View Product This product has multiple variants. The options may be chosen on the product page

  • AZD1208 | pan-PIM kinase inhibitor

    CAS:
    1204144-28-4
    Catalog Number:
    10-4781
    View Product This product has multiple variants. The options may be chosen on the product page

  • BMS-202 | PD-1/PD-L1 inhibitor

    CAS:
    1675203-84-5
    Catalog Number:
    10-4900
    Activity:
    PD-1/PD-L1 inhibitor
    Chemical Name:
    N-[2-[[2-Methoxy-6-[(2-methyl-3-phenylphenyl)methoxy]pyridine-3-yl]methylamino]ethyl]acetamide
    Alternate Name:
    PD-1/PD-L1 Inhibitor 2
    Molecular Weight:
    419.53
    Molecular Formula:
    C25H29N3O3
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $85.00
    View Product This product has multiple variants. The options may be chosen on the product page
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