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Kinases

  • Brigatinib | pan-ALK inhibitor

    CAS:
    1197953-54-0
    Catalog Number:
    10-5034
    Activity:
    pan-ALK inhibitor
    Chemical Names:
    5-Chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2,4- pyrimidinediamine
    Alternate Name:
    AP26113
    Molecular Weight:
    584.02
    Molecular Formula:
    C29H39ClN7O2P
    Solubility:
    Soluble in DMSO (1 mg/ml with warming)
    Physical Properties:
    White to off-white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
    From $50.00
    View Product This product has multiple variants. The options may be chosen on the product page

  • BT2 | BCKDC kinase inhibitor

    CAS:
    34576-94-8
    Catalog Number:
    10-4717
    Activity:
    BCKDC kinase inhibitor
    Chemical Name:
    3,6-Dichlorobenzo[b]thiophene-2-carboxylic acid
    Molecular Weight:
    247.10
    Molecular Formula:
    C9H4Cl2O2S
    Solubility:
    Soluble in DMSO (up to at least 20 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    95% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $50.00
    View Product This product has multiple variants. The options may be chosen on the product page

  • Buparlisib | PI3-kinase inhibitor

    CAS:
    944396-07-0
    Catalog Number:
    10-4325
    Activity:
    pan-Class I PI3-kinase inhibitor
    Chemical Names:
    5-(2,6-Dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridine-2-amine; NVP-BKM120
    Molecular Weight:
    410.39
    Molecular Formula:
    C18H21F3N6O2
    Solubility:
    Soluble in DMSO (15 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $60.00
    View Product This product has multiple variants. The options may be chosen on the product page

  • BX795 | Dual TBK1/IKKε inhibitor – enhances lentiviral transduction efficiency

    CAS:
    702675-74-9
    Catalog Number:
    10-4677
    Activity:
    Dual inhibitor of TBK1/IKKε
    Chemical Names:
    N-[3-[[5-Iodo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
    Molecular Weight:
    591.47
    Molecular Formula:
    C23H26IN7O2S
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >97% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $65.00
    View Product This product has multiple variants. The options may be chosen on the product page

  • Cabozantinib | Met and VEGFR2 inhibitor

    CAS:
    849217-68-1
    Catalog Number:
    10-3231
    Activity:
    Met and VEGFR2 inhibitor
    Chemical Name:
    N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
    Alternate Names:
    XL-184; BMS-907351; Carbozantinib
    Molecular Weight:
    501.51
    Molecular Formula:
    C28H24FN3O5
    Solubility:
    Soluble in DMSO
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
    From $70.00
    View Product This product has multiple variants. The options may be chosen on the product page
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