Approved Drugs
Drugs approved by the FDA or other agencies for use in medicine are excellent tools for research because they are demonstrated to have good absorption (bioavailable), distribution and activity, and pharmacokinetics for use in vivo experiments. They are used in cells or animals for basic research, and for drug discovery (repurposing, benchmarking and other applications).
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Ibrutinib | BTK inhibitor
From $40.00CAS:936563-96-1Catalog Number:10-4757Alternate Name:PCI-32765Activity:BTK inhibitor/Cancer immunotherapy enhancerChemical Name:1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-oneMolecular Weight:440.51Molecular Formula:C25H24N6O2Solubility:Soluble in DMSO ( up to at least 25 mg/ml)Physical Properties:White or off-white solidPurity:99% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Ibudilast | Neuroinflammation inhibitor
From $40.00CAS:50847-11-5Catalog Number:10-2236Activity:Neuroinflammation inhibitorChemical Name:3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridineAlternate Names:2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridine-3-yl 1-propanone; KC-404; AV411Molecular Weight:230.31Molecular Formula:C14H18N2OSolubility:Soluble in DMSO (up to 25 mg/ml) or Ethanol (up to 20 mg/ml)Physical Properties:White solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Idelalisib | Selective PI3Kδ Inhibitor
From $60.00CAS:870281-82-6Catalog Number:10-4820Activity:Selective PI3Kδ InhibitorChemical Name:5-Fluoro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)propyl]quinazolin-4-oneAlternate Names:CAL-101Molecular Weight:415.43Molecular Formula:C21H18FN7OSolubility:Soluble in DMSO (>25 mg/ml)Physical Properties:White solidPurity:>98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.Shipping Code:RT -
Imatinib mesylate | BCR-ABL inhibitor
From $30.00CAS:220127-57-1Catalog Number:10-1060Activity:BCR-ABL inhibitorAlternate Names:GleevecChemical Name:4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonateMolecular Weight:589.73Molecular Formula:C29H31N7O CH3SO3HSolubility:Soluble in DMSO (up to 50 mg/ml) or in Water (up to 50 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 3 months.Shipping Code:RT -
Imiquimod | TLR7 Agonist
From $30.00CAS:99011-02-6Catalog Number:10-4230Alternate Name:R837Activity:TLR7 agonistChemical Name:1-(2-Methylpropyl)imidazo[4,5-c]quinolin-4-amineMolecular Weight:240.30Molecular Formula:C14H16N4Solubility:Soluble in DMSO (2 mg/ml with warming)Physical Properties:White solidPurity:>98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Ingenol-3-angelate | PKC activator
From $110.00CAS:75567-37-2Catalog Number:10-1244Activity:PKC activatorAlternate Names:PEP-005Molecular Weight:460.53Molecular Formula:C25H34O6Solubility:Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 4 mg/ml)Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°C (des.)Stability:Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.Shipping Code:RT
